PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16985099-2	2006	For instance, the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the neurotoxic pyridinium ion metabolite 1-methyl-4-phenylpyridinium by monoamine oxidase (MAO) B in the brain has been of interest to a number of investigators.	pyridine	94-104	monoamine oxidase B	Homo sapiens	151-176	
19669997-1	2009	Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models.	pyridine	176-186	monoamine oxidase B	Homo sapiens	0-25	
3875815-0	1985	Conversion of the neurotoxic precursor 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine into its pyridinium metabolite by human platelet monoamine oxidase type B.	pyridine	93-103	monoamine oxidase B	Homo sapiens	133-157	
29758567-7	2018	The effect of the heteroaromatic substituent on MAO-B inhibition activity, in decreasing order was found to be: cyclohexyl, phenyl>thiophene>pyridine, furane, pyrrole, cyclopentyl.	pyridine	147-155	monoamine oxidase B	Homo sapiens	48-53	
20615716-3	2010	The most active and selective derivative (20), bearing a pyridine moiety on the CN, displayed IC(50)=3.81+/-0.12 nM and selectivity ratio=119 toward hMAO-B.	pyridine	57-65	monoamine oxidase B	Homo sapiens	149-155	
10218814-1	1999	The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites.	pyridine	203-213	monoamine oxidase B	Homo sapiens	142-161	
10218814-1	1999	The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites.	pyridine	203-213	monoamine oxidase B	Homo sapiens	163-168	
8158148-4	1994	Incubation of MBzTP with purified MAO B yields first the dihydropyridinium form, then a mixture of the pyridinium form and another unidentified product, in proportions that depend on the concentrations of MAO B and oxygen.	pyridine	64-74	monoamine oxidase B	Homo sapiens	34-39	
1641061-6	1992	The conversion of MPTP to its corresponding pyridinium-ion derivative through the action of MAO-B is known to be essential for its neurotoxicity.	pyridine	44-54	monoamine oxidase B	Homo sapiens	92-97	
1641061-8	1992	Studies of the changes in absorbance spectra during the MAO-B catalysed oxidation were consistent with the formation of the corresponding pyridinium-ion derivative (MPP+), which is known to be the effective neurotoxin, as the end-product when MPTP was oxidized.	pyridine	138-148	monoamine oxidase B	Homo sapiens	56-61	
2809594-6	1989	The corresponding pyridinium species of MPTP and several of the MPTP analogs inhibited MAO-A competitively with Ki values at micromolar concentrations; in contrast the pyridinium species inhibited MAO-B competitively at considerably higher concentrations (i.e., 100 microM or greater Ki values).	pyridine	18-28	monoamine oxidase B	Homo sapiens	197-202	
2809594-6	1989	The corresponding pyridinium species of MPTP and several of the MPTP analogs inhibited MAO-A competitively with Ki values at micromolar concentrations; in contrast the pyridinium species inhibited MAO-B competitively at considerably higher concentrations (i.e., 100 microM or greater Ki values).	pyridine	168-178	monoamine oxidase B	Homo sapiens	197-202	
9305573-2	1997	The most dramatic illustration of this type of bioactivation process is the conversion of the parkinsonian-inducing neurotoxin MPTP (23) by brain MAO-B to the iminium (dihydropyridinium) metabolite 24 which is oxidized further to the pyridinium species MPP+ (25).	pyridine	175-185	monoamine oxidase B	Homo sapiens	146-151	
8289189-4	1994	The corresponding pyridinium forms of trans-MTHS and its analogs were more potent inhibitors of MAO A (Ki values between 0.3 and 5 microM) than of MAO B, for which the Ki values varied greatly.	pyridine	18-28	monoamine oxidase B	Homo sapiens	147-152