PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30225256-2 2018 Manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase-1 (GPx1) have evolved to address primary defense against free radical mediated damage in mitochondria. Free Radicals 140-152 catalase Homo sapiens 40-48 30225256-2 2018 Manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase-1 (GPx1) have evolved to address primary defense against free radical mediated damage in mitochondria. Free Radicals 140-152 catalase Homo sapiens 50-53 20925122-9 2012 A significant decrease in antioxidant components like catalase, soluble thiol, and recently recognized uric acid worsened the situation by generating free radicals as observed in significant rise in malondialdehyde level, which finally increased DNA fragmentation and arsenic-associated mutagenesis and carcinogenesis. Free Radicals 150-163 catalase Homo sapiens 54-62 29421221-4 2018 Superoxide dismutase and catalase are supposed to be potential antioxidant enzymes to scavange free radicals. Free Radicals 95-108 catalase Homo sapiens 25-33 26921793-11 2016 Catalase is the main antioxidant, involved in the removal of free radicals in OCs users. Free Radicals 61-74 catalase Homo sapiens 0-8 24573976-7 2014 We measured decreased catalase activity starting from 5 min after anesthesia and activity of this antioxidant enzyme was not recovered even after 60 min of anesthesia.We found that spinal injection of ropivacaine results in increased levels of free radicals in spinal fluid, which may stimulate antioxidant defense system of spinal fluid during anesthesia. Free Radicals 244-257 catalase Homo sapiens 22-30 27650614-9 2016 The main antioxidants responsible for the removal of free radicals in men aged 20-25 years and women aged 32-39 years are superoxide dismutase and catalase, while the glutathione peroxidase activity declines. Free Radicals 53-66 catalase Homo sapiens 147-155 27062029-9 2016 These results indicate that catalase inhibition inflicts changes in the free radical metabolism during reoxygenation, prompting a stress-response that is a reorganization in other enzymatic antioxidant defenses to minimize alterations in the redox homeostasis in land snails. Free Radicals 72-84 catalase Homo sapiens 28-36 26381636-2 2015 Catalase being an antioxidant ensures the effective removal of free radicals and improvement in fluoride mediated remineralization from the enamel microstructure which if retained may harm the integrity and affect the hardness of enamel. Free Radicals 63-76 catalase Homo sapiens 0-8 25497738-2 2015 Glutathione peroxidase (GPx) is one of the first endogenous antioxidant defense enzymes, and it works cooperatively with superoxide dismutase (SOD) and catalase (CAT) to detoxify free radicals from the cellular environment. Free Radicals 179-192 catalase Homo sapiens 152-160 25497738-2 2015 Glutathione peroxidase (GPx) is one of the first endogenous antioxidant defense enzymes, and it works cooperatively with superoxide dismutase (SOD) and catalase (CAT) to detoxify free radicals from the cellular environment. Free Radicals 179-192 catalase Homo sapiens 162-165 20723561-1 2010 Hemoglobin (Hb) conjugated with the antioxidant enzymes (SOD and CAT), by employing dicarboxymethylated poly(ethylene glycol), was designed for protection of hemoglobin against free radicals. Free Radicals 177-190 catalase Homo sapiens 65-68 21167936-7 2011 The left shift was abolished by scavenging free radicals with superoxide dismutase and catalase. Free Radicals 43-56 catalase Homo sapiens 87-95 17912575-4 2008 There is much evidence that antioxidant team that covers glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phopshate destroy reactive oxygen species and other free radicals through enzymatic as well as nonenzymatic means. Free Radicals 202-215 catalase Homo sapiens 80-88 20152822-11 2010 Catalase may act on reducing levels of ROS, further indicating that accumulation of free radicals indeed leads to death in cryopreserved hematopoietic cells. Free Radicals 84-97 catalase Homo sapiens 0-8 19203061-3 2008 The antioxidative enzyme catalase diminishes free radical hydrogen-peroxyde, which can be very toxic to pancreatic cells. Free Radicals 45-57 catalase Homo sapiens 25-33 18950483-4 2008 On the other hand, oxidoreductases constitute one of the most important free radical scavenger systems typified by catalase, superoxide dismutase and glutathione peroxidase.In this work, proteomics, Gene Ontology mapping and Directed Acyclic Graphs (DAG) are employed to detect and quantify differential oxidoreductase enzyme expressions between HepG2 cells and normal human liver tissues. Free Radicals 72-84 catalase Homo sapiens 115-123 18697608-7 2008 Ibuprofen inhibits COX enzymes and thereby inhibits generation of free radicals during prostaglandins synthesis, which may be responsible for reduction in lipid peroxidation, super oxide dismutase levels and for high catalase levels. Free Radicals 66-79 catalase Homo sapiens 217-225 16940931-3 2006 Once produced, free radicals are removed by antioxidant defenses, including the enzymes SOD, GPx, and CAT. Free Radicals 15-28 catalase Homo sapiens 102-105 17116052-9 2006 CONCLUSIONS: We suggest that increased oxidative stress might contribute to the pathophysiological mechanisms of pre-eclampsia and eclampsia, and that AA and CAT might have a protective role via free radical-scavenging properties. Free Radicals 195-207 catalase Homo sapiens 158-161 17197733-16 2007 CONCLUSIONS: The results of our study suggest higher oxygen-free radical production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and catalase activity, support to the oxidative stress in osteoarthritis. Free Radicals 60-72 catalase Homo sapiens 160-168 16910626-10 2006 LITERATURE FINDINGS: In schizophrenia there is evidence for deregulation of free radical metabolism, as detected by abnormal activity of critical antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase). Free Radicals 76-88 catalase Homo sapiens 216-224 17240813-4 2006 Superoxide dismutase, catalase and glutathione peroxidase are major anti-oxidant enzymes, which protect against free radicals. Free Radicals 112-125 catalase Homo sapiens 22-30 16504657-5 2006 On the contrary, superoxide dismutase, catalase, glutathione, and glutathione peroxidase are involved in protecting against free radicals. Free Radicals 124-137 catalase Homo sapiens 39-47 16217560-5 2005 Therefore, a coordinated regulation of the free radical scavenging system, which comprises enzymatic components such as catalase, superoxide dismutase and ascorbate peroxidase, and non-enzymatic molecules such as ascorbate and glutathione is essential. Free Radicals 43-55 catalase Homo sapiens 120-128 12094909-8 2002 The results indicated that dietary intake of vitamins A, C, and E may influence blood levels of catalase possibly through their antioxidant effects on free radicals. Free Radicals 151-164 catalase Homo sapiens 96-104 15453097-2 2004 Using immunocytochemistry and Western blots, we tested the hypothesis that this vulnerability to free radical toxicity results, in part, from developmental lack of superoxide dismutases (SOD)-1 and -2, catalase, and glutathione peroxidase (GPx) in the telencephalic white matter of the human fetus. Free Radicals 97-109 catalase Homo sapiens 202-210 12821281-2 2003 These free radicals are neutralized by an elaborate antioxidant defense system consisting of enzymes such as catalase, superoxide dismutase, glutathione peroxidase, and numerous non-enzymatic antioxidants, including vitamins A, E and C, glutathione, ubiquinone, and flavonoids. Free Radicals 6-19 catalase Homo sapiens 109-117 12821284-8 2003 Enhanced free radical production is paralleled by impaired antioxidant mechanisms; as indicated by burn-related decreases in superoxide dismutase, catalase, glutathione, alpha tocopherol, and ascorbic acid levels. Free Radicals 9-21 catalase Homo sapiens 147-155 12372096-7 2002 When the controls plus various treatments with free radicals were subject to different antioxidants, including superoxide dismutase, catalase, glutathione peroxidase, and desferrioxamine, it was found that catalase alone was most effective in scavenging hydroxyl radicals as determined by the decrease in pyridinoline cross-links. Free Radicals 47-60 catalase Homo sapiens 206-214 12940695-2 2003 BACKGROUND: Superoxide dismutase, glutathione peroxidase and catalase are the three main enzymes that control the biological effects of the reactive oxygen species (free radicals). Free Radicals 165-178 catalase Homo sapiens 61-69 12372460-9 2002 CONCLUSION(S): Abnormal expression of catalase in the eutopic and ectopic endometrium strongly suggests pathologic involvement of free radicals in endometriosis and adenomyosis. Free Radicals 130-143 catalase Homo sapiens 38-46 11975768-2 2001 Under normal situations, the human body has a free radical scavenger system (catalase, superoxide dismutase) that can detoxify free radicals. Free Radicals 127-140 catalase Homo sapiens 77-85 11606190-8 2001 Co-incubation with extracellular free-radical inhibitors (superoxide dismutase, catalase and mannitol) markedly reduced the effect of Hcy on ET-1 production. Free Radicals 33-45 catalase Homo sapiens 80-88 17216981-10 2001 Free radicals related markers revealed significant higher level of lipid peroxide, as well as significant lower levels of SOD activity, catalase activity and glutathione S-transferase among exposed workers than among controls (p<0.0001 for all). Free Radicals 0-13 catalase Homo sapiens 136-144 8945013-1 1996 The defenses against the production of free radicals and reactive oxygen species (ROS) are to be found in plasma (ascorbate, urate, alpha tocopherol) and in erythrocytes (superoxide dismutase or SOD; catalase or CAT; glutathione peroxidase or GPx). Free Radicals 39-52 catalase Homo sapiens 200-208 11225659-17 2000 Although metformin monotherapy ameliorated the imbalance between free radical-induced increase in lipid peroxidation (by reducing the MDA level in both erythrocytes and plasma) and decreased plasma and cellular antioxidant defences (by increasing the erythrocyte activities of Cu, Zn, SOD, catalase and GSH level) and decreased erythrocyte susceptibility to oxidative stress, it had negligible effect to scavenge Fe ion-induced free radical generation in a phospholipid-liposome system. Free Radicals 65-77 catalase Homo sapiens 290-298 10591076-6 1999 Since the inhibitory effect was suppressed by the addition of catalase, the gentamicin mediated effect probably is due to production of free radicals. Free Radicals 136-149 catalase Homo sapiens 62-70 9796506-2 1998 Oxygen-derived free radicals are controlled by various cellular defense mechanisms consisting of enzymatic such as superoxide dismutase, catalase, glutathion peroxidase and nonenzymatic scavenger components. Free Radicals 15-28 catalase Homo sapiens 137-145 9383735-9 1997 Antioxidants, such as methionine, sodium thiosulfate, catalase, or platinum, prevented Met oxidation in rhuMAb HER2, presumably as free radicals or oxygen scavengers. Free Radicals 131-144 catalase Homo sapiens 54-62 9078694-1 1997 Endogenous oxygen radical scavengers such as glutathione peroxidase (GSH-Px), catalase (CAT), glutathione and vitamin E are powerful regulatory systems against free radical toxicity. Free Radicals 160-172 catalase Homo sapiens 78-86 9078694-1 1997 Endogenous oxygen radical scavengers such as glutathione peroxidase (GSH-Px), catalase (CAT), glutathione and vitamin E are powerful regulatory systems against free radical toxicity. Free Radicals 160-172 catalase Homo sapiens 88-91 19245448-7 1996 Considering the involvement of catalase in skin defence against oxygen-derived free radicals generated, its increased activity may explain the beneficial role of Vichy water observed in various dermatoses. Free Radicals 79-92 catalase Homo sapiens 31-39 8892529-12 1996 Superoxide dismutase (300 units/ml) and catalase (500 units/ml) significantly reduced the effects of the xanthine/xanthine oxidase-generated free radicals on NCC viability. Free Radicals 141-154 catalase Homo sapiens 40-48 8945013-1 1996 The defenses against the production of free radicals and reactive oxygen species (ROS) are to be found in plasma (ascorbate, urate, alpha tocopherol) and in erythrocytes (superoxide dismutase or SOD; catalase or CAT; glutathione peroxidase or GPx). Free Radicals 39-52 catalase Homo sapiens 212-215 3129432-6 1988 Endothelial cell cultures incubated with PEG-superoxide dismutase and PEG-catalase for 24 h and then extensively washed were protected from the damaging effects of reactive oxygen species derived from exogenous xanthine oxidase as judged by two criteria: decreased release of intracellular 51Cr-labeled proteins and free radical-induced changes in membrane fluidity, measured by electron paramagnetic resonance spectroscopy of endothelial membrane proteins covalently labeled with 4-maleimido-2,2,6,6-tetramethylpiperidinooxyl. Free Radicals 316-328 catalase Homo sapiens 74-82 8126753-5 1994 In addition, the metal ion chelator DETAPAC and ROS scavengers ethanol, mannitol, and PEG-SOD/catalase were found to inhibit free radical production. Free Radicals 125-137 catalase Homo sapiens 86-102 7905906-6 1994 Mechanisms have evolved to restrict and control such processes, partly by compartmentation, and partly by antioxidant defences such as chain-breaking antioxidant compounds capable forming stable free radicals (e.g. ascorbate, alpha-tocopherol) and the evolution of enzyme systems (e.g. superoxide dismutase, catalase, peroxidases) that diminish the intracellular concentration of the ROS. Free Radicals 195-208 catalase Homo sapiens 308-316 2029651-4 1991 The cell possesses highly efficient protective mechanisms, including antioxidants such as vitamins C and E and the enzymes superoxide dismutase and catalase, all of which are designed to prevent the occurrence of free radical-induced injury under normal conditions. Free Radicals 213-225 catalase Homo sapiens 148-156 2226373-8 1990 Intrinsic enzymatic mechanisms for control of free radical reactions include activation of catalase, peroxidase, and superoxide dismutase. Free Radicals 46-58 catalase Homo sapiens 91-99 3072554-4 1988 Peroxidation of lipids is a major consequence of exposure to these species and the cell possesses various enzymes, including superoxide dismutase and catalase, as well as cellular antioxidants which are able to scavenge oxygen free radicals and repair peroxidized lipids. Free Radicals 227-240 catalase Homo sapiens 150-158 8840658-1 1996 Free radicals scavengers superoxide dismuatase (SOD) and catalase and lipid peroxidation were studied in 45 patients of aluminium phosphide poisoning irrespective of age and sex admitted to a hospital in north India during the January 1992 to December 1993. Free Radicals 0-13 catalase Homo sapiens 57-65 7619452-6 1995 Humans are well endowed with antioxidant defences against AOS; these antioxidants, or free radical scavengers, include ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), beta-carotene, coenzyme Q10, enzymes such as catalase and superoxide dismutase, and trace elements including selenium and zinc. Free Radicals 86-98 catalase Homo sapiens 221-229 7898413-3 1995 Free radicals are normally neutralized by efficient systems in the body that include the antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and the nutrient-derived antioxidant small molecules (vitamin E, vitamin C, carotenes, flavonoids, glutathione, uric acid, and taurine). Free Radicals 0-13 catalase Homo sapiens 132-140 8117850-2 1993 We found that PolyHb-SOD-catalase is effective in scavenging oxygen-derived free radicals. Free Radicals 76-89 catalase Homo sapiens 25-33 1450598-1 1992 Superoxide dismutase, glutathione peroxidase and catalase are the three main enzymatic systems of defense of the organism against free radicals and peroxides. Free Radicals 130-143 catalase Homo sapiens 49-57 2076828-1 1990 Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls. Free Radicals 185-198 catalase Homo sapiens 73-81 33486434-8 2021 The present method provides a convenient means for investigating the usefulness of CAT measurements in biological sample assessing the potential for free radical-induced pathology. Free Radicals 149-161 catalase Homo sapiens 83-86 3277900-3 1988 In such experiments, various free radical scavenging agents, including superoxide dismutase, catalase, and mannitol, have been shown to improve the tolerance of the heart to protracted global ischemia. Free Radicals 29-41 catalase Homo sapiens 93-101 2983288-3 1985 This free radicals attack is controlled by a protective system, both enzymatic (superoxide dismutase, catalase, glutahione peroxidase) and non enzymatic (vitamine E). Free Radicals 5-18 catalase Homo sapiens 102-110 6412380-2 1983 In several studies of prolonged global myocardial ischemia, the administration of free radical scavenging agents, such as superoxide dismutase, catalase, and mannitol, resulted in significantly better recovery of left ventricular function following reperfusion. Free Radicals 82-94 catalase Homo sapiens 144-152 13126454-0 1954 Free radical production in oxidation-reduction reactions of peroxidase, catalase and metmyoglobin. Free Radicals 0-12 catalase Homo sapiens 72-80 3298506-3 1987 Experimental studies have shown that free radical scavengers (e.g., N-[2-mercaptopropionyl]glycine) and enzymes that scavenge or degrade reactive species of oxygen (superoxide dismutase or catalase) can reduce the mass of myocardial tissue that undergoes irreversible injury. Free Radicals 37-49 catalase Homo sapiens 189-197 6298444-6 1982 An important aspect of free-radical-mediated toxicity is that it is moderated by several cellular defense mechanisms including superoxide dismutase, catalase, glutathione peroxidase, vitamin E and reduced glutathione. Free Radicals 23-35 catalase Homo sapiens 149-157 7389028-0 1980 Free radical intermediate in the N-demethylation of aminopyrine by catalase-cumene hydroperoxide system. Free Radicals 0-12 catalase Homo sapiens 67-75 32234491-5 2020 The liver serum biomarkers such as ALT and AST, elated levels of free radicals inducing oxidative stress characterized by a surge in Nrf-2, FOXO-1 and HO-1 genes and diminution of anti-oxidant activity characterized by a decline in SOD, GPx, and CAT genes. Free Radicals 65-78 catalase Homo sapiens 246-249