PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15324348-4 2004 OBJECTIVES: The objective of this study was to investigate glutathione peroxidase, lactoferrin and myeloperoxidase, which play an essential role in free radical production and defenses, and the proinflammatory cytokine interleukin-1beta (IL-1beta), which is important in the regulation of immunological and inflammatory reactions in human periodontal diseases. Free Radicals 148-160 myeloperoxidase Homo sapiens 99-114 29258826-1 2018 Myeloperoxidase, an abundant neutrophil enzyme, promotes oxidative damage during inflammation by generating hypohalous acids and free radicals. Free Radicals 129-142 myeloperoxidase Homo sapiens 0-15 25698971-3 2015 Myeloperoxidase (MPO), a heme-containing enzyme that catalyzes the production of free radicals and hypochlorite, is released by neutrophils during the inflammatory response to bacterial infections. Free Radicals 81-94 myeloperoxidase Homo sapiens 0-15 25698971-3 2015 Myeloperoxidase (MPO), a heme-containing enzyme that catalyzes the production of free radicals and hypochlorite, is released by neutrophils during the inflammatory response to bacterial infections. Free Radicals 81-94 myeloperoxidase Homo sapiens 17-20 26405383-13 2012 The elevated levels of MPO contribute to the increased oxidative stress as free radicals are produced by the reaction catalyzed by it. Free Radicals 75-88 myeloperoxidase Homo sapiens 23-26 23110185-8 2012 Treatment of neutrophils from healthy subjects with TNFalpha, IL-1beta, or IL-8 enhanced free radicals generation and NETs formation, which was mediated through the activation of NADPH oxidase and MPO. Free Radicals 89-102 myeloperoxidase Homo sapiens 197-200 16641309-1 2006 Myeloperoxidase, an antimicrobial enzyme, produces oxidative free radicals. Free Radicals 61-74 myeloperoxidase Homo sapiens 0-15 16266270-0 2005 Generation of free radicals during decomposition of hydroperoxide in the presence of myeloperoxidase or activated neutrophils. Free Radicals 14-27 myeloperoxidase Homo sapiens 85-100 28905321-4 2019 The goal of this study was to identify the important genes involved in the pathogenesis of diabetes complications and foot ulcer and its association with the free radical-producing enzyme, the myeloperoxidase (MPO). Free Radicals 158-170 myeloperoxidase Homo sapiens 193-208 28905321-4 2019 The goal of this study was to identify the important genes involved in the pathogenesis of diabetes complications and foot ulcer and its association with the free radical-producing enzyme, the myeloperoxidase (MPO). Free Radicals 158-170 myeloperoxidase Homo sapiens 210-213 24490735-3 2013 The generation of such free radical intermediates by HOCl and other reactive halogen species is accompanied by the development of halogenative stress, which causes a number of socially important diseases, such as cardiovascular, neurodegenerative, infectious, and other diseases usually associated with inflammatory response and characterized by the appearance of biomarkers of myeloperoxidase and halogenative stress. Free Radicals 23-35 myeloperoxidase Homo sapiens 378-393 21972015-3 2011 We constructed an updated conceptual landmark regarding the paramount role of free radicals in phagocyte defense systems (phagocyte oxidase, myeloperoxidase, and nitric oxide/peroxynitrite system) on natural immunity. Free Radicals 78-91 myeloperoxidase Homo sapiens 141-156 17602675-3 2007 We have investigated the metabolism of AG by myeloperoxidase (MPO) and the formation of an MPO protein free radical. Free Radicals 103-115 myeloperoxidase Homo sapiens 91-94 16266270-3 2005 The data suggest that the activated neutrophils located in the inflammatory foci and secreting MPO into the extracellular space can convert hydroperoxides into free radicals initiating lipid peroxidation and other free radical reactions and, thus, promoting destruction of protein-lipid complexes (biological membranes, blood lipoproteins, etc. Free Radicals 160-173 myeloperoxidase Homo sapiens 95-98 15125662-5 2004 In a physiomimetic model study, myeloperoxidase-promoted free radical-induced fragmentation of either hydroperoxy- or hydroxyoctecadienoate esters of 2-lyso-PC in small unilamellar vesicles produced the 9-hydroxy-12-oxododec-10-enoic acid (HODA) ester HODA-PC. Free Radicals 57-69 myeloperoxidase Homo sapiens 32-47 12800195-2 2003 Oxidation by MPO produces free radicals that demonstrate genotoxic properties. Free Radicals 26-39 myeloperoxidase Homo sapiens 13-16 11368132-20 2001 Adding myeloperoxidase to neutrophil granulocytes, the production of free radicals decreases. Free Radicals 69-82 myeloperoxidase Homo sapiens 7-22 11479475-1 2001 BACKGROUND: One of the enzymes involved in the production of free radicals in atherosclerotic plaques is myeloperoxidase (MPO). Free Radicals 61-74 myeloperoxidase Homo sapiens 105-120 11479475-1 2001 BACKGROUND: One of the enzymes involved in the production of free radicals in atherosclerotic plaques is myeloperoxidase (MPO). Free Radicals 61-74 myeloperoxidase Homo sapiens 122-125 11328262-11 2001 CONCLUSIONS: (i) free radical-induced lipid peroxidation and suppression of antioxidizing enzymes play an important role in gastric damage induced by aspirin; (ii) increased myeloperoxidase activity suggests activated neutrophils to be the major source of these radicals; (iii) vitamin C protects against ASA-induced damage due to its anti-oxidizing activity. Free Radicals 17-29 myeloperoxidase Homo sapiens 174-189 12737551-4 2003 Free radical-induced oxidative cleavage of DHA-PC promoted by myeloperoxidase or copper ions generates similar mixtures of these phospholipids. Free Radicals 0-12 myeloperoxidase Homo sapiens 62-77 12694338-2 2003 Myeloperoxidase (MPO) is an abundant enzyme involved in the production of free radicals. Free Radicals 74-87 myeloperoxidase Homo sapiens 0-15 12694338-2 2003 Myeloperoxidase (MPO) is an abundant enzyme involved in the production of free radicals. Free Radicals 74-87 myeloperoxidase Homo sapiens 17-20 12595076-1 2003 Myeloperoxidase (MPO)-catalyzed one-electron oxidation of endogenous phenolic constituents (e.g., antioxidants, hydroxylated metabolites) and exogenous compounds (e.g., drugs, environmental chemicals) generates free radical intermediates: phenoxyl radicals. Free Radicals 211-223 myeloperoxidase Homo sapiens 0-15 12595076-1 2003 Myeloperoxidase (MPO)-catalyzed one-electron oxidation of endogenous phenolic constituents (e.g., antioxidants, hydroxylated metabolites) and exogenous compounds (e.g., drugs, environmental chemicals) generates free radical intermediates: phenoxyl radicals. Free Radicals 211-223 myeloperoxidase Homo sapiens 17-20 11738154-2 2001 The aim of the study was to test how extracellular levels of myeloperoxidase (MPO; a granulocyte enzyme playing role in free radical production) change by age and what effect this change has on the production of the free radical superoxide anion by neutrophils. Free Radicals 120-132 myeloperoxidase Homo sapiens 61-76 11738154-2 2001 The aim of the study was to test how extracellular levels of myeloperoxidase (MPO; a granulocyte enzyme playing role in free radical production) change by age and what effect this change has on the production of the free radical superoxide anion by neutrophils. Free Radicals 120-132 myeloperoxidase Homo sapiens 78-81 7748188-6 1995 Although the metal ion-catalyzed Haber-Weiss reaction is considered the classical pathway for neutrophil-derived hydroxyl radical, an alternative mechanism, such as the myeloperoxidase-dependent pathway, may undoubtedly contribute to the formation of this free radical by stimulated neutrophils. Free Radicals 256-268 myeloperoxidase Homo sapiens 169-184 10443140-7 1999 Besides the fact that intensified MPO activity through enhanced consumption might induce the decreased accumulation of H2O2 (a reactive oxygen species, substrate of MPO), MPO also has a role in the termination of the whole process of free radical production in granulocytes by the inactivation of the NADPH-oxidase system. Free Radicals 234-246 myeloperoxidase Homo sapiens 34-37 10443140-7 1999 Besides the fact that intensified MPO activity through enhanced consumption might induce the decreased accumulation of H2O2 (a reactive oxygen species, substrate of MPO), MPO also has a role in the termination of the whole process of free radical production in granulocytes by the inactivation of the NADPH-oxidase system. Free Radicals 234-246 myeloperoxidase Homo sapiens 165-168 10443140-7 1999 Besides the fact that intensified MPO activity through enhanced consumption might induce the decreased accumulation of H2O2 (a reactive oxygen species, substrate of MPO), MPO also has a role in the termination of the whole process of free radical production in granulocytes by the inactivation of the NADPH-oxidase system. Free Radicals 234-246 myeloperoxidase Homo sapiens 165-168 10443140-8 1999 This means that the growing intracellular MPO activity and the increased amount of enzyme released induce the decrease of the amount of free radicals produced during the "respiratory burst" and this is advantageous from the point of view of vasoprotection. Free Radicals 136-149 myeloperoxidase Homo sapiens 42-45 9706251-11 1998 LADH was also inactivated after incubation with MPO-generated free radicals such as the Chloropromazine and Paracetamol radicals (Table 2). Free Radicals 62-75 myeloperoxidase Homo sapiens 48-51 1663060-1 1991 We have demonstrated with electron paramagnetic resonance (EPR) that organic hydroperoxides are decomposed to free radicals by both human polymorphonuclear leukocytes (PMNs) and purified myeloperoxidase. Free Radicals 110-123 myeloperoxidase Homo sapiens 187-202 8660393-0 1995 Myeloperoxidase as a generator of drug free radicals. Free Radicals 39-52 myeloperoxidase Homo sapiens 0-15 8406134-1 1993 Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of myeloperoxidase (a marker of neutrophil activation) in the systemic blood. Free Radicals 99-112 myeloperoxidase Homo sapiens 197-212 8439949-3 1993 Bone marrow contains high levels of myeloperoxidase which can catalyze the further metabolism of the phenolic metabolites to reactive free radical species. Free Radicals 134-146 myeloperoxidase Homo sapiens 36-51 1337652-0 1992 Influence of free radical scavengers on myeloperoxidase activity and lipid peroxidation in acute skin grafts. Free Radicals 13-25 myeloperoxidase Homo sapiens 40-55 1663060-6 1991 Our studies suggest that myeloperoxidase in PMNs is primarily responsible for the decomposition of organic hydroperoxides to free radicals. Free Radicals 125-138 myeloperoxidase Homo sapiens 25-40 1503677-4 1992 Drug oxidation by myeloperoxidase leads to free radical metabolite formation; these reactive free radicals can oxidise glutathione to a thiyl free radical, which in the presence of oxygen forms oxygen-derived free radicals. Free Radicals 93-106 myeloperoxidase Homo sapiens 18-33 2167682-1 1990 The univalent oxidation of chlorpromazine (CPZ) by the myeloperoxidase (MPO-H2O2) system led to the formation of a cation free radical (CPZ+) which was observed optically at 527 nm. Free Radicals 122-134 myeloperoxidase Homo sapiens 55-70 2167682-1 1990 The univalent oxidation of chlorpromazine (CPZ) by the myeloperoxidase (MPO-H2O2) system led to the formation of a cation free radical (CPZ+) which was observed optically at 527 nm. Free Radicals 122-134 myeloperoxidase Homo sapiens 72-75 2987307-2 1985 We evaluated the ability of the oxidants produced by the neutrophil myeloperoxidase system to generate free radical intermediates from several such compounds. Free Radicals 103-115 myeloperoxidase Homo sapiens 68-83 6291348-14 1982 PMN MPO appears to be a target for the antioxidant/free radical scavenging effects of NSAIDs. Free Radicals 51-63 myeloperoxidase Homo sapiens 4-7 6282074-4 1982 Non-steroidal anti-inflammatory drugs (NSAIDs) able to act as antioxidant free radical scavengers have recently been shown to inhibit luminol-enhanced chemiluminescence (CL) which results from the MPO-H2O2-Cl- reaction. Free Radicals 74-86 myeloperoxidase Homo sapiens 197-200