PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33376698-2	2020	This is as a result of iron redox reaction which generates free radicals that cause peroxidation of lipid-rich pancreas, leading to reduced insulin sensitivity.	Free Radicals	59-72	insulin	Homo sapiens	140-147	
35195377-6	2022	RESULTS: Free radical induced oxidation was significantly elevated (p<0.001), total antioxidant activity was significantly decreased (p<0.001) and associated with insulin resistance (p=0.019) and lipid metabolism shifts (p<0.05) in patients with NAFLD and type 2 diabetes.	Free Radicals	9-21	insulin	Homo sapiens	163-170	
25975232-8	2015	The lowest interactions with free radicals were characteristic for intermediate-acting insulin - Insuman Basal.	Free Radicals	29-42	insulin	Homo sapiens	87-94	
32215179-3	2020	Oxidative stress refers to an imbalance between free radical production and the antioxidant system leading to a reduction of peripheral insulin sensitivity and contributing to the development of T2DM via several molecular mechanisms.	Free Radicals	48-60	insulin	Homo sapiens	136-143	
25975232-7	2015	The strongest interactions with free radicals were observed for the short-acting insulin - Insuman Rapid.	Free Radicals	32-45	insulin	Homo sapiens	81-88	
31705360-1	2020	Free radical-induced oxidative stress contributes to the development of metabolic syndromes (Mets), including overweight, hyperglycemia, insulin resistance and pro-inflammatory state.	Free Radicals	0-12	insulin	Homo sapiens	137-144	
25817343-2	2015	Although recently insulin generated free radicals via NAD(P)H has been documented but the molecular mechanism is still under investigation.	Free Radicals	36-49	insulin	Homo sapiens	18-25	
25817343-8	2015	Conclusively, the present study showed that over expression of insulin might stimulate cardiac hypertrophic signal via up regulation of free radicals and down regulation of antioxidants enzymes including SOD activity.	Free Radicals	136-149	insulin	Homo sapiens	63-70	
16843828-3	2006	The present study aimed to clarify the mechanisms through which insulin generates free radicals and to assess whether pravastatin modulates such effects.	Free Radicals	82-95	insulin	Homo sapiens	64-71	
17612655-0	2007	Insulin withdrawal induces apoptosis via a free radical-mediated mechanism.	Free Radicals	43-55	insulin	Homo sapiens	0-7	
21892559-6	2011	However, metabolic changes such as insulin resistance (IR) are developed, being a common factor in the retention of fatty acids (FA) within the hepatocytes with oxidation and production of free radicals at the mitochondrial level, which are capable of causing lipid peroxidation, cytokine production, and necrosis.	Free Radicals	189-202	insulin	Homo sapiens	35-42	
19604133-6	2009	This review is intended to provide an overview of literature pertaining to the role of free radical production following feeding, as related to the development of insulin resistance, Type 2 diabetes and CVD.	Free Radicals	87-99	insulin	Homo sapiens	163-170	
19622391-3	2009	Obesity and insulin resistance promote disease by increasing oxidative damage to proteins, lipids and DNA as the result of a combination of increased free radical production and an impaired ability of cells to detoxify the radicals and repair damaged molecules.	Free Radicals	150-162	insulin	Homo sapiens	12-19	
16843828-7	2006	The present study demonstrates a novel mechanism by which insulin stimulates the generation of free radicals in human fibroblasts, ex vivo.	Free Radicals	95-108	insulin	Homo sapiens	58-65	
7533613-25	1995	Taken together with previous data the present results suggest that islet production of low physiological levels of free radicals such as NO and H202 may serve as important modulators of insulin secretory processes.	Free Radicals	115-128	insulin	Homo sapiens	186-193	
7555601-2	1995	Therefore, we decided to evaluate the influence of intensive insulin therapy on selected indicators of free radical production.	Free Radicals	103-115	insulin	Homo sapiens	61-68	
15111505-0	2004	Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3"-kinase-dependent mechanism in human skin fibroblasts ex vivo.	Free Radicals	18-31	insulin	Homo sapiens	0-7	
10693917-7	2000	It has been suggested that insulin resistance may be accompanied by intracellular production of free radicals.	Free Radicals	96-109	insulin	Homo sapiens	27-34	
8492724-0	1993	Evidence for a relationship between free radicals and insulin action in the elderly.	Free Radicals	36-49	insulin	Homo sapiens	54-61	
7811700-10	1994	Moreover, zinc depletion appeared to increase the susceptibility of insulin to free radicals.	Free Radicals	79-92	insulin	Homo sapiens	68-75	
8492724-6	1993	In conclusion, in aged patients a significant relationship between free radical production and insulin action seems to exist.	Free Radicals	67-79	insulin	Homo sapiens	95-102