PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6284205-6 1982 These studies of the binding of peroxide clarify the mechanism by which cytochrome c oxidase catalyzes the reduction of oxygen to water without the formation of free-radical intermediates. Free Radicals 161-173 cytochrome c, somatic Homo sapiens 72-84 10602301-8 1999 A quartet line similar to DMPO-OH adducts and uncomplexed free radicals (g = 2.0058) was detected using the ESR spin-trapping method in the H(2)O(2)/gallic acid/cytochrome c system. Free Radicals 58-71 cytochrome c, somatic Homo sapiens 161-173 1337538-3 1992 The reoxidation of cytochrome c at the electrode surface upon reduction by superoxide was monitored using both xanthine/xanthine oxidase and stimulated neutrophils as sources of the free radical. Free Radicals 182-194 cytochrome c, somatic Homo sapiens 19-31 1337538-5 1992 A biopsy needle probe electrode based on cytochrome c immobilised at PACE and suitable for continuous monitoring of free radical production was constructed and characterised. Free Radicals 116-128 cytochrome c, somatic Homo sapiens 41-53 10443940-11 1999 These results suggested that Cu-NTA-induced apoptosis in HL-60 cells was, at least in part, triggered by free radical-induced lipid peroxidation of membrane, which induced the release of cytochrome c from mitochondria and activation of caspase-3. Free Radicals 105-117 cytochrome c, somatic Homo sapiens 187-199 7493039-4 1995 Methemoglobin and cytochrome c decomposed hydrogen peroxide slower than microperoxidase but generated free radicals continuously. Free Radicals 102-115 cytochrome c, somatic Homo sapiens 18-30 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Free Radicals 13-26 cytochrome c, somatic Homo sapiens 69-81 19513819-2 2009 Formation of free radicals was triggered by methemoglobin (metHb) or cytochrome c (cyt c) binding to the model lipid membranes composed of zwitterionic lipid phosphatidylcholine (PC) and anionic lipid cardiolipin (CL). Free Radicals 13-26 cytochrome c, somatic Homo sapiens 83-88 6297496-1 1982 Purified ferredoxin-(cytochrome c)-NADP+ oxidoreductase and xanthine oxidase were found to catalyse the reduction of nitrofurantoin to the free radical. Free Radicals 139-151 cytochrome c, somatic Homo sapiens 21-33 21128733-1 2011 The peroxidase-type reactivity of cytochrome c is proposed to play a role in free radical production and/or apoptosis. Free Radicals 77-89 cytochrome c, somatic Homo sapiens 34-46 21833601-5 2011 Deltapsi(m) decrease was accompanied by reactive oxygen species (ROS) increase and cytochrome c (cyt c) disappearance, suggesting a link between free radical generation and intramitochondrial cyt c degradation. Free Radicals 145-157 cytochrome c, somatic Homo sapiens 192-197 28978450-2 2017 It funnels electrons coming from NADH and ubiquinol to cytochrome c, but it is also capable of producing significant amounts of the free radical superoxide. Free Radicals 132-144 cytochrome c, somatic Homo sapiens 55-67 24596381-4 2014 Based on the obtained results it is believed that cell survival depends strongly on the action of free radicals produced at the given concentration of the incubated CytC and VitC as well as on the specific reaction rate constants (k: l mol(-1) s(-1)) of the involved processes. Free Radicals 98-111 cytochrome c, somatic Homo sapiens 165-169 17454840-10 2007 A possible mechanism is that increased neurodegeneration in ALS caused by free radical production decreases the concentrations of CyC. Free Radicals 74-86 cytochrome c, somatic Homo sapiens 130-133 19559788-0 2009 Superoxide radical protects liposome-contained cytochrome c against oxidative damage promoted by peroxynitrite and free radicals. Free Radicals 115-128 cytochrome c, somatic Homo sapiens 47-59 16889691-1 2006 To elaborate the peroxidase activity of cytochrome c in the generation of free radicals from H2O2, the mechanism of DNA cleavage mediated by the cytochrome c/H2O2 system was investigated. Free Radicals 74-87 cytochrome c, somatic Homo sapiens 40-52 17085975-8 2006 These results suggest that H2O2-mediated cytochrome c oligomerization is due to oxidative damage resulting from free radicals generated by a combination of the peroxidase activity of cytochrome c and the Fenton reaction of free iron released from the oxidatively-damaged protein. Free Radicals 112-125 cytochrome c, somatic Homo sapiens 41-53 17085975-8 2006 These results suggest that H2O2-mediated cytochrome c oligomerization is due to oxidative damage resulting from free radicals generated by a combination of the peroxidase activity of cytochrome c and the Fenton reaction of free iron released from the oxidatively-damaged protein. Free Radicals 112-125 cytochrome c, somatic Homo sapiens 183-195 16889691-1 2006 To elaborate the peroxidase activity of cytochrome c in the generation of free radicals from H2O2, the mechanism of DNA cleavage mediated by the cytochrome c/H2O2 system was investigated. Free Radicals 74-87 cytochrome c, somatic Homo sapiens 145-157 15030396-3 2004 Electron chain transport disruption increases free radical production leading to multiple conductance channel opening, release of cytochrome c and caspase activation. Free Radicals 46-58 cytochrome c, somatic Homo sapiens 130-142 12761334-2 2003 TPZ requires metabolic activation to give a cytotoxic free radical species, and this hypoxia-mediated process is carried out by a variety of cellular reductases, including NADPH cytochrome c (P450) reductase (P540R). Free Radicals 54-66 cytochrome c, somatic Homo sapiens 178-190 15157803-5 2004 As a decrease in mitochondrial cytochrome c content is also prevented by allopurinol, we suggest that xanthine oxidase plays an important role in the free radical production that precedes the apoptotic cascade and cell death after paraquat exposition. Free Radicals 150-162 cytochrome c, somatic Homo sapiens 31-43