PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24607445-4 2014 The profound neuroprotective properties of propargyl-based inhibitors of MAO-B in preclinical experiments have drawn attention to the possibility of employing these drugs for their neuroprotective effect in neurodegenerative diseases, and have raised the question of the involvement of the MAO-mediated reaction as a source of reactive free radicals. Free Radicals 336-349 monoamine oxidase B Homo sapiens 73-78 7816197-10 1994 The up-regulation of monoamine oxidase B in plaque-associated astrocytes in Alzheimer"s disease--in analogy to its proposed role in neurodegenerative disorders such as Parkinson"s disease--might, indirectly, be a potential source of cytotoxic free radicals. Free Radicals 243-256 monoamine oxidase B Homo sapiens 21-40 10619718-1 1999 An active role of monoamine oxidase B (MAO-B) in the pathogenesis of neurodegenerative disorders such as Parkinson"s disease has been proposed as the enzyme is known to be a generator of free radicals which seem to be responsible for neuron oxidative damage. Free Radicals 187-200 monoamine oxidase B Homo sapiens 18-37 10619718-1 1999 An active role of monoamine oxidase B (MAO-B) in the pathogenesis of neurodegenerative disorders such as Parkinson"s disease has been proposed as the enzyme is known to be a generator of free radicals which seem to be responsible for neuron oxidative damage. Free Radicals 187-200 monoamine oxidase B Homo sapiens 39-44 7830050-1 1995 L-3,4-Dihydroxyphenylalanine (L-dopa) is toxic for human neuroblastoma cells NB69 and its toxicity is related to several mechanisms including quinone formation and enhanced production of free radicals related to the metabolism of dopamine via monoamine oxidase type B. Free Radicals 187-200 monoamine oxidase B Homo sapiens 243-267 31416364-1 2019 MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute to the aetiology of the AD. Free Radicals 76-89 monoamine oxidase B Homo sapiens 0-5