PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24376801-4 2013 Adding ferrous citrate (FC) complexes to the primary cultured mouse cerebral endothelial cells (CEC) to mimic the SAH conditions, we also showed that FC up-regulates NOS2 through nuclear translocation of NFkappaB induced by free radicals generation. Free Radicals 224-237 nitric oxide synthase 2, inducible Mus musculus 166-170 21419832-2 2011 Moreover, an overproduction of nitric oxide due to both cytosolic (iNOS) and mitochondrial (i-mtNOS) inducible nitric oxide synthases causes free radicals generation and oxidative/nitrosative stress, contributing to mitochondrial dysfunction and neuronal cell death. Free Radicals 141-154 nitric oxide synthase 2, inducible Mus musculus 67-71 16537416-0 2006 Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. Free Radicals 0-12 nitric oxide synthase 2, inducible Mus musculus 38-69 19376221-5 2009 Free radical generation was also decreased by pretreatment with the xanthine oxidase (XO) inhibitor allopurinol, the iron chelator Desferal, and the inducible nitric oxide synthase (iNOS) inhibitor 1400W. Free Radicals 0-12 nitric oxide synthase 2, inducible Mus musculus 149-180 19376221-5 2009 Free radical generation was also decreased by pretreatment with the xanthine oxidase (XO) inhibitor allopurinol, the iron chelator Desferal, and the inducible nitric oxide synthase (iNOS) inhibitor 1400W. Free Radicals 0-12 nitric oxide synthase 2, inducible Mus musculus 182-186 23029446-0 2012 Ferrous citrate up-regulates the NOS2 through nuclear translocation of NFkappaB induced by free radicals generation in mouse cerebral endothelial cells. Free Radicals 91-104 nitric oxide synthase 2, inducible Mus musculus 33-37 18559982-0 2008 Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Free Radicals 41-53 nitric oxide synthase 2, inducible Mus musculus 19-23 18559982-6 2008 Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Free Radicals 0-12 nitric oxide synthase 2, inducible Mus musculus 94-98 18559982-6 2008 Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Free Radicals 0-12 nitric oxide synthase 2, inducible Mus musculus 136-140 18559982-6 2008 Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Free Radicals 144-156 nitric oxide synthase 2, inducible Mus musculus 94-98 18559982-6 2008 Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Free Radicals 144-156 nitric oxide synthase 2, inducible Mus musculus 136-140 18559982-9 2008 Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression. Free Radicals 149-161 nitric oxide synthase 2, inducible Mus musculus 199-203 11441215-9 2001 CONCLUSIONS: These results indicate that oxygen-derived free radicals, particularly superoxide, play an important role in the iNOS gene expression after SAH and provide a molecular basis for the protective role of SOD against vasospasm after SAH. Free Radicals 56-69 nitric oxide synthase 2, inducible Mus musculus 126-130