PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27156193-4 2016 Introduction of a fluorine at ortho position to benzylic phosphoramide as in 1b results in better stability of the conjugate prior to activation while maintaining its antiproliferative activity upon activation by PSA. phosphoramide 57-70 kallikrein related peptidase 3 Homo sapiens 213-216 27156193-0 2016 Design and synthesis of peptide conjugates of phosphoramide mustard as prodrugs activated by prostate-specific antigen. phosphoramide 46-59 kallikrein related peptidase 3 Homo sapiens 93-118 24139844-0 2013 Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA). phosphoramide 61-74 kallikrein related peptidase 3 Homo sapiens 111-142 24139844-3 2013 These conjugates were cleaved by PSA efficiently and exclusively after the expected glutamine residue to release 4-NH2-CPA, the activated prodrug form of phosphoramide mustard. phosphoramide 154-167 kallikrein related peptidase 3 Homo sapiens 33-36 24139844-5 2013 These results indicate a potential of the conjugate 3 as an anticancer prodrug of phosphoramide mustard for selective PSA activation. phosphoramide 82-95 kallikrein related peptidase 3 Homo sapiens 118-121 19345094-4 2009 LC/MS analysis of the incubation solution of this isomer with PSA suggests that 4-NH(2)-CPA is released upon proteolysis and quickly degrades to cytotoxic phosphoramide mustard. phosphoramide 155-168 kallikrein related peptidase 3 Homo sapiens 62-65 19345094-0 2009 Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA). phosphoramide 111-124 kallikrein related peptidase 3 Homo sapiens 151-182 19345094-1 2009 In an effort to develop proteolytically activated prodrugs of phosphoramide mustard by prostate-specific antigen (PSA), a series of tetrapeptide (Cbz-Ser-Ser-Phe-Tyr)-conjugated 4-aminocyclophosphamide (4-NH(2)-CPA) isomers were synthesized and evaluated as substrates of PSA. phosphoramide 62-75 kallikrein related peptidase 3 Homo sapiens 87-118 19345094-1 2009 In an effort to develop proteolytically activated prodrugs of phosphoramide mustard by prostate-specific antigen (PSA), a series of tetrapeptide (Cbz-Ser-Ser-Phe-Tyr)-conjugated 4-aminocyclophosphamide (4-NH(2)-CPA) isomers were synthesized and evaluated as substrates of PSA. phosphoramide 62-75 kallikrein related peptidase 3 Homo sapiens 114-117