PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15766247-3 2005 We have used synthetic pyrrole-imidazole polyamides, which bind specific sequences in the minor groove, to demonstrate that DNA binding by hERR2 is sensitive to the presence of polyamides in both the upstream minor groove CTE site and the minor groove of the ERE half-site. 1,1,1-trifluoro-2-chloroethane 222-225 estrogen related receptor beta Homo sapiens 139-144 15766247-4 2005 Thus, polyamides can inhibit hERR2 by two mechanisms, by direct steric blockage of minor groove DNA contacts mediated by the CTE and by changing the helical geometry of DNA such that major groove interactions are weakened. 1,1,1-trifluoro-2-chloroethane 125-128 estrogen related receptor beta Homo sapiens 29-34 9218433-4 1997 To better understand the mechanism by which DNA specificity is achieved, the solution structure of the DNA-binding domain of hERR2 (residues 96-194) consisting of the two putative zinc fingers and the requisite 26-amino acid CTE was analyzed by multidimensional heteronuclear magnetic resonance spectroscopy. 1,1,1-trifluoro-2-chloroethane 225-228 estrogen related receptor beta Homo sapiens 125-130