PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19560931-1 2009 A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors. methylsulfonyl 57-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-77 29031075-4 2017 In vitro and in vivo assays for data profiling the new candidates revealed the significant improvement in the potency and selectivity against COX-2 of 6-methoxytetrahydrocarbazole 4 (IC50 = 0.97 mumol) to verify the effect of ring extension in comparison to indomethacin (IC50 = 2.63 mumol), and 6-methylsulfonyltetrahydrocarbazole 10a (IC50 = 0.28 mumol) to verify the effect of ring extension and introduction of methylsulfonyl group. methylsulfonyl 298-312 mitochondrially encoded cytochrome c oxidase II Homo sapiens 142-147 19560931-1 2009 A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors. methylsulfonyl 57-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 179-184 15051057-1 2004 Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. methylsulfonyl 76-90 mitochondrially encoded cytochrome c oxidase II Homo sapiens 189-194 10328307-2 1999 Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo. methylsulfonyl 137-151 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-44