PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8825194-7 1996 Thus, our study suggests that cytochrome P450 is the enzyme catalyzing the metabolic activation of CH and its metabolites (TCA and TCE) leading to lipid peroxidation, and that CYP2E1 may be the major isozyme responsible. 2,2,2-trichloroethanol 131-134 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 30-45 25424545-5 2015 The quantitative relationship was evaluated between strain-, dose, and time-dependent formation of TCE metabolites from cytochrome P-450-mediated oxidation (trichloroacetic acid [TCA], dichloroacetic acid [DCA], and trichloroethanol) and glutathione conjugation [S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)glutathione], and various kidney toxicity phenotypes. 2,2,2-trichloroethanol 216-232 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 120-136