PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25617738-0 2015 Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2alpha and SOAT1 followed by selective efflux to HDL. 7-ketocholesterol 28-45 phospholipase A2 group IVA Homo sapiens 90-100 14992685-0 2004 Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2. 7-ketocholesterol 28-44 phospholipase A2 group IVA Homo sapiens 130-156 14992685-4 2004 In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA2 (cytosolic phospholipase A2) that synthesize two essential factors for vascular wall integrity, NO (nitric oxide) and arachidonic acid. 7-ketocholesterol 53-69 phospholipase A2 group IVA Homo sapiens 153-158 14992685-4 2004 In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA2 (cytosolic phospholipase A2) that synthesize two essential factors for vascular wall integrity, NO (nitric oxide) and arachidonic acid. 7-ketocholesterol 53-69 phospholipase A2 group IVA Homo sapiens 160-186 14992685-11 2004 The results show that 7-oxocholesterol inhibits eNOS and cPLA2 activation by altering a Ca2+-independent upstream step of PI3K and ERK1/2 cascades, whereas LPC desensitizes eNOS by interfering with receptor-activated signalling pathways. 7-ketocholesterol 22-38 phospholipase A2 group IVA Homo sapiens 57-62