PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19464253-0	2009	Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.	7-ketocholesterol	86-103	thymoma viral proto-oncogene 1	Mus musculus	15-18	
14559920-4	2004	In this study, we demonstrate that, in the murine macrophage-like cell line P388D1, oxysterols (25-hydroxycholesterol and 7-ketocholesterol) induced the degradation of the prosurvival protein kinase AKT (protein kinase B).	7-ketocholesterol	122-139	thymoma viral proto-oncogene 1	Mus musculus	199-202	
21575614-5	2011	With alpha-tocopherol (400 muM), which was capable of counteracting 7-ketocholesterol-induced apoptosis, Akt and GSK3beta dephosphorylation were inhibited as well as Mcl-1 degradation.	7-ketocholesterol	68-85	thymoma viral proto-oncogene 1	Mus musculus	105-108	
21575614-6	2011	These data underline that the potential protective effects of alpha-tocopherol against 7-ketocholesterol-induced apoptosis do not depend on the cell line considered, and that the cascade of events (Akt/GSK3beta/Mcl-1) constitutes a link between 7-ketocholesterol-induced cytoplasmic membrane dysfunctions and mitochondrial depolarisation leading to apoptosis.	7-ketocholesterol	245-262	thymoma viral proto-oncogene 1	Mus musculus	198-201	
19464253-2	2009	Previously we observed enhanced degradation of Akt in P388D1 moncocyte/macrophages following treatment with 25-hydroxycholesterol (25-OH) or 7-ketocholesterol (7-KC).	7-ketocholesterol	141-158	thymoma viral proto-oncogene 1	Mus musculus	47-50	
19464253-4	2009	We show that treatment with 25-OH or 7-KC results in the accumulation of poly-ubiquitinated Akt, an effect that is enhanced by co-treatment with the proteasome inhibitor MG-132.	7-ketocholesterol	37-41	thymoma viral proto-oncogene 1	Mus musculus	92-95