PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21575614-5 2011 With alpha-tocopherol (400 muM), which was capable of counteracting 7-ketocholesterol-induced apoptosis, Akt and GSK3beta dephosphorylation were inhibited as well as Mcl-1 degradation. 7-ketocholesterol 68-85 thymoma viral proto-oncogene 1 Mus musculus 105-108 21575614-6 2011 These data underline that the potential protective effects of alpha-tocopherol against 7-ketocholesterol-induced apoptosis do not depend on the cell line considered, and that the cascade of events (Akt/GSK3beta/Mcl-1) constitutes a link between 7-ketocholesterol-induced cytoplasmic membrane dysfunctions and mitochondrial depolarisation leading to apoptosis. 7-ketocholesterol 245-262 thymoma viral proto-oncogene 1 Mus musculus 198-201 19464253-0 2009 Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. 7-ketocholesterol 86-103 thymoma viral proto-oncogene 1 Mus musculus 15-18 19464253-2 2009 Previously we observed enhanced degradation of Akt in P388D1 moncocyte/macrophages following treatment with 25-hydroxycholesterol (25-OH) or 7-ketocholesterol (7-KC). 7-ketocholesterol 141-158 thymoma viral proto-oncogene 1 Mus musculus 47-50 19464253-4 2009 We show that treatment with 25-OH or 7-KC results in the accumulation of poly-ubiquitinated Akt, an effect that is enhanced by co-treatment with the proteasome inhibitor MG-132. 7-ketocholesterol 37-41 thymoma viral proto-oncogene 1 Mus musculus 92-95 14559920-4 2004 In this study, we demonstrate that, in the murine macrophage-like cell line P388D1, oxysterols (25-hydroxycholesterol and 7-ketocholesterol) induced the degradation of the prosurvival protein kinase AKT (protein kinase B). 7-ketocholesterol 122-139 thymoma viral proto-oncogene 1 Mus musculus 199-202