PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26709800-3 2016 In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release. 7-ketocholesterol 54-71 sphingomyelin phosphodiesterase 1 Homo sapiens 21-24 26709800-5 2016 In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs. 7-ketocholesterol 13-18 sphingomyelin phosphodiesterase 1 Homo sapiens 171-176 26709800-5 2016 In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs. 7-ketocholesterol 13-18 sphingomyelin phosphodiesterase 1 Homo sapiens 210-215