PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29197565-4 2018 Lately, two metabolites that are markedly increased in NP-C patients are arising as biomarkers for this disease screening: 7-ketocholesterol and cholestane-3beta,5alpha,6beta-triol, both oxidized cholesterol products. 7-ketocholesterol 123-140 NPC intracellular cholesterol transporter 1 Homo sapiens 55-59 26733147-4 2016 As expected, NP-C patients showed significant increase of both C-triol and 7-KC. 7-ketocholesterol 75-79 NPC intracellular cholesterol transporter 1 Homo sapiens 13-17 21518695-3 2011 Recently, we demonstrated that two cholesterol oxidation products, specifically cholestane-3beta,5alpha,6beta-triol (3beta,5alpha,6beta-triol) and 7-ketocholesterol (7-KC), were markedly increased in the plasma of human NPC1 subjects, suggesting a role for these oxysterols in diagnosis of NPC1 disease and evaluation of therapeutics in clinical trials. 7-ketocholesterol 147-164 NPC intracellular cholesterol transporter 1 Homo sapiens 220-224 27256227-1 2016 OBJECTIVE: To investigate 7-ketocholesterol (7-KC) level in the blood, clinical features and gene mutation of Niemann-Pick disease type C (NPC). 7-ketocholesterol 26-43 NPC intracellular cholesterol transporter 1 Homo sapiens 110-137 27256227-1 2016 OBJECTIVE: To investigate 7-ketocholesterol (7-KC) level in the blood, clinical features and gene mutation of Niemann-Pick disease type C (NPC). 7-ketocholesterol 26-43 NPC intracellular cholesterol transporter 1 Homo sapiens 139-142 26239048-2 2015 Recent studies have shown that plasma cholestane-3beta,5alpha,6beta-triol (CT) and 7-ketocholesterol (7-KC) could be potential biomarkers for the diagnosis of NPC patients. 7-ketocholesterol 83-100 NPC intracellular cholesterol transporter 1 Homo sapiens 159-162 10751394-10 2000 Finally, we showed that the lysosomal cholesterol pool in NP-C cells was substantially and preferentially reduced by incubating cells with the oxysterols, 25-hydroxycholesterol and 7-ketocholesterol; these findings suggest a new pharmacological approach to the treatment of NP-C disease. 7-ketocholesterol 181-198 NPC intracellular cholesterol transporter 1 Homo sapiens 58-62 34177581-7 2021 Plasma 7-ketocholesterol (7-KC), an emerging biomarker of NP-C1, was the primary endpoint. 7-ketocholesterol 7-24 NPC intracellular cholesterol transporter 1 Homo sapiens 58-63