PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15572675-7	2004	Silencing of IRE-1 and JNK inhibition downregulated Nox-4 expression and subsequently prevented the UPR-dependent cell death induced by 7-Kchol.	7-ketocholesterol	136-143	NADPH oxidase 4	Homo sapiens	52-57	
23770348-0	2013	7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B.	7-ketocholesterol	0-17	NADPH oxidase 4	Homo sapiens	76-80	
19526729-1	2009	7-Ketocholesterol (7-Kchol, oxidized cholesterol) is an important mediator of cell death in atherosclerosis mediated by up-regulated Nox 4 gene expression.	7-ketocholesterol	0-17	NADPH oxidase 4	Homo sapiens	133-138	
19526729-1	2009	7-Ketocholesterol (7-Kchol, oxidized cholesterol) is an important mediator of cell death in atherosclerosis mediated by up-regulated Nox 4 gene expression.	7-ketocholesterol	19-26	NADPH oxidase 4	Homo sapiens	133-138	
15572675-0	2004	NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells.	7-ketocholesterol	31-48	NADPH oxidase 4	Homo sapiens	16-21	
15572675-3	2004	This specific effect of 7-Kchol is mediated by a robust upregulation (threefold from the basal level) of Nox-4, a reactive oxygen species (ROS)-generating NAD(P)H oxidase homologue.	7-ketocholesterol	24-31	NADPH oxidase 4	Homo sapiens	105-110	
15572675-4	2004	This effect was highlighted by silencing Nox-4 expression with a specific small interfering RNA, which significantly reduced the 7-Kchol-induced production of ROS and abolished apoptotic events.	7-ketocholesterol	129-136	NADPH oxidase 4	Homo sapiens	41-46	
15572675-6	2004	We also showed that 7-Kchol activated the IRE-1/Jun-NH(2)-terminal kinase (JNK)/AP-1 signaling pathway to promote Nox-4 expression.	7-ketocholesterol	20-27	NADPH oxidase 4	Homo sapiens	114-119	
15572675-8	2004	These findings demonstrate that Nox-4 plays a key role in 7-Kchol-induced SMC death, which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis.	7-ketocholesterol	58-65	NADPH oxidase 4	Homo sapiens	32-37	
15572675-8	2004	These findings demonstrate that Nox-4 plays a key role in 7-Kchol-induced SMC death, which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis.	7-ketocholesterol	58-65	NADPH oxidase 4	Homo sapiens	130-135