PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34043989-5 2021 An increase in AMP:ATP and ADP:ATP ratio leads to activation of AMPK signaling by upstream mediators such as LKB1 and CamKK. Adenosine Monophosphate 15-18 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 64-68 33508418-3 2021 Meanwhile, the peroxisome proliferator activated receptor (PPARalpha) blocker, GW6471, with the Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) activator, AICAR, were applied in vitro study to clarify the role of PPARalpha/SREBP-1c/FAS/GPAT/AMPK signal pathway in the process. Adenosine Monophosphate 124-127 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 155-159 34036247-4 2021 Metabolomics coupled with biochemical and functional analyses revealed that ALDOA triggered the activation of adenosine-5"-monophosphate (AMP)-activated protein kinase (AMPK), which we demonstrate played essential promalignant activities in ALDOA-expressing cells. Adenosine Monophosphate 138-141 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 169-173 32682846-4 2020 It was shown that zinc significantly induced the level of Beclin1 and LC3B by activating adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway. Adenosine Monophosphate 117-120 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 148-152 32623953-7 2021 Conversely, HAS2 can be phosphorylated by AMP activated protein kinase (AMPK), a master metabolic regulator activated by low ATP/AMP ratios, which inhibits HA secretion. Adenosine Monophosphate 42-45 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 72-76 32856352-5 2020 ANXA1 activated formyl peptide receptor 2 (FPR2) receptors and the downstream adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) signaling cascade, leading to SC proliferation and migration in vitro. Adenosine Monophosphate 106-109 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 137-141 32519244-1 2020 The studies have shown that 5"-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is involved in Alzheimer"s disease (AD) pathology, but the effects of AMPK on AD-like Tau abnormal phosphorylation and its underlying mechanism remains unclear. Adenosine Monophosphate 56-59 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 87-91 32519244-1 2020 The studies have shown that 5"-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is involved in Alzheimer"s disease (AD) pathology, but the effects of AMPK on AD-like Tau abnormal phosphorylation and its underlying mechanism remains unclear. Adenosine Monophosphate 56-59 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 163-167 32565721-12 2020 In addition, the Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway (P < 0.01) was inhibited in the HP group. Adenosine Monophosphate 45-48 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 76-80 32730244-4 2020 We developed and validated a mathematical model of AMPK signaling dynamics, and then applied global parameter sensitivity analyses with data-informed constraints to predict that AMPK activity dynamics are determined principally by ADP and not AMP. Adenosine Monophosphate 51-54 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 178-182 32733440-1 2020 Intracellular adenosine monophosphate (AMP) is indispensable for cellular metabolic processes, and it is interconverted to ADP and/or ATP or activates AMP-activated protein kinase (AMPK). Adenosine Monophosphate 39-42 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 151-179 32733440-1 2020 Intracellular adenosine monophosphate (AMP) is indispensable for cellular metabolic processes, and it is interconverted to ADP and/or ATP or activates AMP-activated protein kinase (AMPK). Adenosine Monophosphate 39-42 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 181-185 28386315-3 2017 In HIRI, ischemia induces the decline of ATP and the increased ratio of AMP/ATP, which promotes the phosphorylation and activation of AMPK. Adenosine Monophosphate 72-75 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 134-138 32244507-1 2020 AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor, mediating the adaptation to low energy levels by deactivating anabolic processes and activating catabolic processes in order to restore the cellular ATP supply when the cellular AMP/ATP ratio is increased. Adenosine Monophosphate 0-3 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 32445451-2 2020 Here we summarized the energy sensor adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and its agonist berberine can combat the common underlying pathological events of neurodegeneration including oxidative stress, neuroinflammation, mitochondrial disorder, glutamate excitotoxicity, apoptosis, autophagy disorder and neurovascular units disruption. Adenosine Monophosphate 65-68 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 96-100 31042624-4 2019 This study shows that metformin suppressed CD133 expression mainly by affecting the CD133 P1 promoter via adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling but not the mammalian target of rapamycin (mTOR). Adenosine Monophosphate 131-134 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 162-166 30478170-6 2019 To understand the mechanisms of full and partial AMPK activation, we determined the crystal structures of fully active phosphorylated AMPK alpha1beta1gamma1 bound to AMP and R734/R739 as well as partially active nonphosphorylated AMPK bound to R734 and AMP and phosphorylated AMPK bound to R734 in the absence of added nucleotides at <3-A resolution. Adenosine Monophosphate 49-52 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 134-138 30478170-6 2019 To understand the mechanisms of full and partial AMPK activation, we determined the crystal structures of fully active phosphorylated AMPK alpha1beta1gamma1 bound to AMP and R734/R739 as well as partially active nonphosphorylated AMPK bound to R734 and AMP and phosphorylated AMPK bound to R734 in the absence of added nucleotides at <3-A resolution. Adenosine Monophosphate 134-137 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 49-53 29130361-9 2018 In addition, AMP-activated protein kinase (AMPK) was activated, probably because of an increased AMP:ATP ratio and decreased expression of mitochondrial electron transport complex components. Adenosine Monophosphate 13-16 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 43-47 32182713-2 2020 A high ATP/AMP ratio has a correlation with diabetes that induces suppression of AMP-activated protein kinase (AMPK). Adenosine Monophosphate 11-14 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 81-109 32182713-2 2020 A high ATP/AMP ratio has a correlation with diabetes that induces suppression of AMP-activated protein kinase (AMPK). Adenosine Monophosphate 11-14 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 111-115 31877369-5 2020 Positive effects were observed on glucose homeostasis due to the down-regulation of AMPK/Akt/GSK-3beta pathway, as indicated by the suppressions of adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK), protein kinase (Akt) phosphorylation, glycogen synthase kinase 3 beta (GSK-3beta), and the hepatic insulin resistance. Adenosine Monophosphate 148-174 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 84-88 31877369-5 2020 Positive effects were observed on glucose homeostasis due to the down-regulation of AMPK/Akt/GSK-3beta pathway, as indicated by the suppressions of adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK), protein kinase (Akt) phosphorylation, glycogen synthase kinase 3 beta (GSK-3beta), and the hepatic insulin resistance. Adenosine Monophosphate 148-174 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 207-211 31877369-5 2020 Positive effects were observed on glucose homeostasis due to the down-regulation of AMPK/Akt/GSK-3beta pathway, as indicated by the suppressions of adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK), protein kinase (Akt) phosphorylation, glycogen synthase kinase 3 beta (GSK-3beta), and the hepatic insulin resistance. Adenosine Monophosphate 84-87 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 207-211 30478170-6 2019 To understand the mechanisms of full and partial AMPK activation, we determined the crystal structures of fully active phosphorylated AMPK alpha1beta1gamma1 bound to AMP and R734/R739 as well as partially active nonphosphorylated AMPK bound to R734 and AMP and phosphorylated AMPK bound to R734 in the absence of added nucleotides at <3-A resolution. Adenosine Monophosphate 49-52 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 134-138 30478170-6 2019 To understand the mechanisms of full and partial AMPK activation, we determined the crystal structures of fully active phosphorylated AMPK alpha1beta1gamma1 bound to AMP and R734/R739 as well as partially active nonphosphorylated AMPK bound to R734 and AMP and phosphorylated AMPK bound to R734 in the absence of added nucleotides at <3-A resolution. Adenosine Monophosphate 49-52 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 134-138 30666163-10 2019 Furthermore, metformin significantly activated Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and its downstream glycogen synthase kinase 3beta (GSK-3beta), block the expression of AMPK, and GSK-3beta with siRNA partially reversed metformin-induced cytotoxicity and restored the expression of c-FLIPL in lung cancer cells. Adenosine Monophosphate 75-78 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 106-110 30666163-10 2019 Furthermore, metformin significantly activated Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and its downstream glycogen synthase kinase 3beta (GSK-3beta), block the expression of AMPK, and GSK-3beta with siRNA partially reversed metformin-induced cytotoxicity and restored the expression of c-FLIPL in lung cancer cells. Adenosine Monophosphate 75-78 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 199-203 28336748-2 2017 A key sensor of cellular energy is the adenosine-5"-monophosphate (AMP)-activated protein kinase (AMPK), which is the core component of a signaling network that regulates energy and nutrient metabolism. Adenosine Monophosphate 67-70 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 98-102 28386315-5 2017 In addition to the changed AMP/ATP ratio, the activated CaMKKbeta by increased intracelluar Ca2+ and the overproduction of reactive oxygen species (ROS) are also involved in the activation of AMPK during HIRI. Adenosine Monophosphate 27-30 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 192-196 28000716-1 2016 The heterotrimeric AMP-activated protein kinase (AMPK), consisting of alpha, beta and gamma subunits, is a stress-sensing enzyme that is activated by phosphorylation of its activation loop in response to increases in cellular AMP. Adenosine Monophosphate 19-22 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 49-53 24748590-8 2014 However, when combined with classical AMPK activators, such as metformin, phenformin, oligomycin, or hypoxia, which impact AMPK heterotrimers more broadly via elevation of cellular AMP levels, A-769662 induced more profound AMPK phosphorylation and subsequent glucose uptake stimulation. Adenosine Monophosphate 38-41 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 123-127 26440826-10 2016 RESULTS: Inhibition of GSK-3beta activity resulted in a significant decline of cellular ATP production, leading to a significant increase of AMP/ATP ratio, a strong trigger of AMP-activated protein kinase (AMPK) activation in prostate cancer PC-3 cells. Adenosine Monophosphate 141-144 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 176-204 26440826-10 2016 RESULTS: Inhibition of GSK-3beta activity resulted in a significant decline of cellular ATP production, leading to a significant increase of AMP/ATP ratio, a strong trigger of AMP-activated protein kinase (AMPK) activation in prostate cancer PC-3 cells. Adenosine Monophosphate 141-144 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 206-210 25742316-2 2015 Metformin and salicylate both increase AMP-activated protein kinase (AMPK) activity but by distinct mechanisms, with metformin altering cellular adenylate charge (increasing AMP) and salicylate interacting directly at the AMPK beta1 drug-binding site. Adenosine Monophosphate 39-42 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 69-73 25659498-1 2015 INTRODUCTION: In non-gestational tissues, the activation of adenosine monophosphate (AMP)-activated kinase (AMPK) is associated with potent anti-inflammatory actions. Adenosine Monophosphate 85-88 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 108-112 24748590-8 2014 However, when combined with classical AMPK activators, such as metformin, phenformin, oligomycin, or hypoxia, which impact AMPK heterotrimers more broadly via elevation of cellular AMP levels, A-769662 induced more profound AMPK phosphorylation and subsequent glucose uptake stimulation. Adenosine Monophosphate 38-41 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 123-127 21116708-1 2011 AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Adenosine Monophosphate 0-3 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 21623793-2 2011 Increased cytoplasmic AMP and Ca(2+) levels are the major activators of neuronal AMPK signaling. Adenosine Monophosphate 22-25 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 81-85 22917563-1 2012 The role of the main intracellular energy sensor adenosine monophosphate (AMP)-activated protein kinase (AMPK) in the induction of autophagic response and cell death was investigated in SH-SY5Y human neuroblastoma cells exposed to the dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA). Adenosine Monophosphate 74-77 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 105-109 22496891-5 2012 Mechanistic studies indicate that glucose deprivation-mediated suppression of T-antigen is partly influenced by 5"-activated AMP kinase (AMPK), an important sensor of the AMP/ATP ratio in cells. Adenosine Monophosphate 125-128 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 137-141 12747837-1 2003 AMP-activated protein kinase (AMPK) is a multisubstrate enzyme activated by increases in AMP during metabolic stress caused by exercise, hypoxia, lack of cell nutrients, as well as hormones, including adiponectin and leptin. Adenosine Monophosphate 0-3 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 21840335-17 2011 These are the insulin like growth factor (IGF-1)/insulin signaling pathway, the sirtuin pathway, the adenosine monophosphate (AMP) activated protein kinase (AMPK) pathway and the target of rapamycin (TOR) pathway. Adenosine Monophosphate 126-129 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 157-161 34968488-4 2022 Liver kinase b1 (LKB1) has been demonstrated to regulate the activity of the mTORC1 signaling cascade by phosphorylating AMP activated protein kinase (AMPK). Adenosine Monophosphate 121-124 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 151-155 33768096-3 2021 Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) is an energy-sensing protein kinase involved in the regulation of fatty acid oxidation and mitochondrial biogenesis in cardiomyocytes. Adenosine Monophosphate 28-31 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 59-63 34871838-9 2022 Importantly, we found that this process is mediated by the Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway. Adenosine Monophosphate 87-90 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 118-122 34930349-1 2021 BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR). Adenosine Monophosphate 64-67 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 95-99 34569605-6 2021 Imatinib-induced AMPK activation was preceded by reduced glucose/pyruvate-dependent respiration, increased glycolysis rates, and a lowered ATP/AMP ratio. Adenosine Monophosphate 143-146 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 17-21 34885077-4 2021 AMP-Activated Protein Kinase (AMPK) is a central energy sensor activated by increased AMP:ATP ratio to restore the cellular energy balance. Adenosine Monophosphate 86-89 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-28 34885077-4 2021 AMP-Activated Protein Kinase (AMPK) is a central energy sensor activated by increased AMP:ATP ratio to restore the cellular energy balance. Adenosine Monophosphate 86-89 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 34582060-1 2021 AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. Adenosine Monophosphate 116-119 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-28 34582060-1 2021 AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. Adenosine Monophosphate 116-119 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 34577590-6 2021 Metformin, a first line antihyperglycemic medication, is a 5"-adenosine monophosphate (AMP)-activated protein kinase (AMPK) activator hypothesized to act as a geroprotective agent. Adenosine Monophosphate 87-90 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 118-122 34466676-4 2021 Specifically, arginine can regulate energy homeostasis via modulating the adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) pathway, and also regulate protein synthesis via activating the target of rapamycin (TOR) signaling pathway. Adenosine Monophosphate 102-105 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 133-137 34302581-9 2022 It mainly includes many pathways related to lipid metabolism such as Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK), Rap1, cAMP, mitogen-activated protein kinase (MAPK), Ras, hypoxia inducible factor-1 (HIF-1), PI3K-Akt, insulin signaling and so on. Adenosine Monophosphate 97-100 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 128-132 34502359-1 2021 Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in the AMP:ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in the modulation of cellular metabolism. Adenosine Monophosphate 94-97 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 122-150 34502359-1 2021 Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in the AMP:ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in the modulation of cellular metabolism. Adenosine Monophosphate 94-97 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 152-156 34434111-7 2021 Besides, metformin increased the expression levels of phosphorylated adenosine 5"-monophosphate (AMP)-activated protein kinase (p-AMPK), microtubule-associated protein (MAP) light chain 3B (LC3B) and Beclin1 proteins, and reduced levels of phosphorylated mammalian target of rapamycin (p-mTOR) and p62 proteins in vivo and in vitro. Adenosine Monophosphate 97-100 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 130-134 34320948-6 2021 Interestingly, modifying the metabolic environmental conditions through the use of 5-aminoimidazole-4-carbox-amide-1-beta-D-ribofuranoside (AICAR), an activator of the 5"-adenosine monophosphate (AMP)-activated protein kinase (AMPK), specifically reduced the growth of hybrids, and also abrogated the invasive capacity of hybrids displaying enhanced glycolysis. Adenosine Monophosphate 196-199 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 227-231 35358642-6 2022 AMP-activated protein kinase (AMPK) modulates energy metabolism in cells and its activation occurs in response to elevated AMP and ADP levels. Adenosine Monophosphate 123-126 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-28 34239878-3 2021 AMPK signaling also modulates energy metabolism in organs such as adipose tissue, brain, muscle, and heart, which are highly dependent on energy consumption via adjusting the AMP/ADP:ATP ratio. Adenosine Monophosphate 175-178 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-4 35358642-6 2022 AMP-activated protein kinase (AMPK) modulates energy metabolism in cells and its activation occurs in response to elevated AMP and ADP levels. Adenosine Monophosphate 123-126 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 35053423-1 2022 The 5"-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. Adenosine Monophosphate 32-35 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 63-67 35129068-7 2022 Moreover, the expressions of apoptosis- and formyl peptide receptor 2 (FPR2) receptors and the adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) pathway-related proteins were determined with Western blot., related proteins and proteins. Adenosine Monophosphate 123-126 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 154-158 33846785-9 2021 Cisplatin inhibited the activity of AMP-activated protein kinase (AMPK) by decreasing the AMP/ATP ratio. Adenosine Monophosphate 36-39 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 66-70 34968169-9 2022 In addition, etomidate caused the activation of Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK), along with upregulated expression levels of phosphorylated AMPKalpha and phosphorylated acetyl-Co A carboxylase (ACC). Adenosine Monophosphate 76-79 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 107-111 34007325-10 2021 In addition, after 17 weeks of feeding, compared with the offspring of a chow-fed mother, the offspring of an obese mouse mother had reduced adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation levels and increased mammalian target of rapamycin (mTOR) phosphorylation levels. Adenosine Monophosphate 169-172 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 200-204