PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9495824-1	1998	To extend our knowledge of the pharmacological profile of human alpha4beta2 neuronal nicotinic receptors, we investigated the action of hexamethonium on the major brain human nicotinic acetylcholine receptor (nAChR) stably expressed in human embryonic kidney 293 cells.	Hexamethonium	136-149	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	175-207	
22902499-5	2012	KEY FINDINGS: Both nAChR and mAChR antagonists (hexamethonium and methacine, respectively), per se, elevated histamine-releasing activity of the HMC-1 and suppressed the MC responses to most of investigated activators (carbachol, compound 48/80, and to a lesser extent aIgG).	Hexamethonium	48-61	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	19-24	
20105082-3	2010	Dihydrobetaerythroidine (antagonist of heteromeric nAChR), and hexamethonium (antagonist of peripheral nAChR), fully antagonized the effect of MDMA.	Hexamethonium	63-76	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	103-108	
23149874-7	2012	Nicotinic acetylcholine receptor (nAChR) blocker hexamethonium, MEK1/2 inhibitor PD98059, p38 MAPK inhibitor SB203580 and NF-kappaB inhibitor PDTC almost completely abolished nicotineinduced CRP expression in mRNA and protein levels in U937 macrophages.	Hexamethonium	49-62	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	0-32	
23149874-7	2012	Nicotinic acetylcholine receptor (nAChR) blocker hexamethonium, MEK1/2 inhibitor PD98059, p38 MAPK inhibitor SB203580 and NF-kappaB inhibitor PDTC almost completely abolished nicotineinduced CRP expression in mRNA and protein levels in U937 macrophages.	Hexamethonium	49-62	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	34-39	
17784838-6	2007	Furthermore, the antiapoptotic effect of nicotine was blocked completely by nicotinic acetylcholine receptor (nAChR) antagonist hexamethonium.	Hexamethonium	128-141	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	76-108	
17784838-6	2007	Furthermore, the antiapoptotic effect of nicotine was blocked completely by nicotinic acetylcholine receptor (nAChR) antagonist hexamethonium.	Hexamethonium	128-141	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	110-115	
9495824-1	1998	To extend our knowledge of the pharmacological profile of human alpha4beta2 neuronal nicotinic receptors, we investigated the action of hexamethonium on the major brain human nicotinic acetylcholine receptor (nAChR) stably expressed in human embryonic kidney 293 cells.	Hexamethonium	136-149	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	209-214	
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Hexamethonium	37-50	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	52-84	
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Hexamethonium	37-50	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	86-91	
34273166-11	2021	Using nicotinic acetylcholine receptor (nAChR) blockers alpha-bungarotoxin and hexamethonium bromide we found that the effects of nicotine on intracellular Ca2+ and oxidative stress were mediated by alpha7 and alpha3 nAChR.	Hexamethonium	79-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	6-38	
34273166-11	2021	Using nicotinic acetylcholine receptor (nAChR) blockers alpha-bungarotoxin and hexamethonium bromide we found that the effects of nicotine on intracellular Ca2+ and oxidative stress were mediated by alpha7 and alpha3 nAChR.	Hexamethonium	79-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	40-45