PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31332074-6 2019 The results show that dCF antagonizes the effect of MBX-2168 with a >40-fold increase in EC50 at 50 muM dCF (63.1 +- 8.7 muM) when compared with MBX-2168 alone (EC50 = 0.2 +- 0.1 muM). Pentostatin 107-110 diencephalon/mesencephalon homeobox 1 Homo sapiens 52-55 33476709-0 2021 Pentostatin Antagonizes the Antiviral Activity of MBX-2168 by Inhibiting the Biosynthesis of the Active Compound. Pentostatin 0-11 diencephalon/mesencephalon homeobox 1 Homo sapiens 50-53 33476709-4 2021 It has been previously demonstrated that co-incubation with pentostatin (dCF), an ADAL-1 inhibitor, antagonizes the anti-viral activity of MBX-2168. Pentostatin 60-71 diencephalon/mesencephalon homeobox 1 Homo sapiens 139-142 33476709-4 2021 It has been previously demonstrated that co-incubation with pentostatin (dCF), an ADAL-1 inhibitor, antagonizes the anti-viral activity of MBX-2168. Pentostatin 73-76 diencephalon/mesencephalon homeobox 1 Homo sapiens 139-142 33476709-6 2021 To test this, we examined the effect dCF has on the conversion of MBX-2168 to a triphosphate in HSV-1 and HCMV-infected cells. Pentostatin 37-40 diencephalon/mesencephalon homeobox 1 Homo sapiens 66-69 33476709-7 2021 Our results demonstrate incubation of MBX-2168 alone or with dCF in HCMV-infected cells resulted in 53.1+-0.7 and 39.4+-1.5 pmol triphosphate/106 cells at 120 hours, respectively. Pentostatin 61-64 diencephalon/mesencephalon homeobox 1 Homo sapiens 38-41 33476709-8 2021 Incubation of MBX-2168 alone or with dCF in Vero cells resulted in 12.8+-0.1 and 6.7+-0.7 pmol triphosphate/106 cells at 24 hours, respectively. Pentostatin 37-40 diencephalon/mesencephalon homeobox 1 Homo sapiens 14-17 33476709-10 2021 As expected, incubation with dCF resulted in the accumulation of MBX-2168-MP in both HFF (9.8+-0.9 pmol MBX-2168-MP/106 cells at 120 hours) and Vero cells (4.7+-0.3 pmol MBX-2168-MP/106 cells at 24 hours) while no detectable levels of monophosphate were observed in cultures not incubated with dCF. Pentostatin 29-32 diencephalon/mesencephalon homeobox 1 Homo sapiens 65-68 33476709-10 2021 As expected, incubation with dCF resulted in the accumulation of MBX-2168-MP in both HFF (9.8+-0.9 pmol MBX-2168-MP/106 cells at 120 hours) and Vero cells (4.7+-0.3 pmol MBX-2168-MP/106 cells at 24 hours) while no detectable levels of monophosphate were observed in cultures not incubated with dCF. Pentostatin 29-32 diencephalon/mesencephalon homeobox 1 Homo sapiens 104-107 33476709-10 2021 As expected, incubation with dCF resulted in the accumulation of MBX-2168-MP in both HFF (9.8+-0.9 pmol MBX-2168-MP/106 cells at 120 hours) and Vero cells (4.7+-0.3 pmol MBX-2168-MP/106 cells at 24 hours) while no detectable levels of monophosphate were observed in cultures not incubated with dCF. Pentostatin 29-32 diencephalon/mesencephalon homeobox 1 Homo sapiens 104-107 33476709-11 2021 We conclude that dCF antagonizes the anti-viral effect of MBX-2168 by inhibiting the production of triphosphate, the active compound. Pentostatin 17-20 diencephalon/mesencephalon homeobox 1 Homo sapiens 58-61 31332074-6 2019 The results show that dCF antagonizes the effect of MBX-2168 with a >40-fold increase in EC50 at 50 muM dCF (63.1 +- 8.7 muM) when compared with MBX-2168 alone (EC50 = 0.2 +- 0.1 muM). Pentostatin 22-25 diencephalon/mesencephalon homeobox 1 Homo sapiens 52-55