PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25628043-7 2015 Compared to AFs from wild-type mice, AFs derived from apoE(-/-) mice exhibited elevated NADPH oxidase activity, O2(-) production and higher mRNA and protein levels of p47phox, correlated with increased capability of proliferation and migration. Superoxides 112-117 apolipoprotein E Mus musculus 54-58 31003152-7 2019 RESULTS: Compared to the control group, liver cells from apoE-KO presented some typical redox imbalance features: higher levels of intracellular ROS (global oxidative stress ~60%, superoxide anion ~82%, and peroxynitrite/hydroxyl radical ~53%), higher amounts of apoptotic cells (up to ~19%) and higher mitochondrial intensity of catalase (+339%) and transferrin spots (+914%). Superoxides 180-196 apolipoprotein E Mus musculus 57-61 27301358-8 2016 These effects were minimized in Apoe(-/-)/Cyp1b1(+/+) mice treated with TMS and in Apoe(-/-)/Cyp1b1(-/-) mice and by concurrent treatment with the superoxide scavenger 4-hydroxyl-2,2,6,6-tetramethylpiperidine-1-oxyl. Superoxides 147-157 apolipoprotein E Mus musculus 32-36 23385237-4 2013 The production of both superoxide and hydrogen peroxide in bone marrow cells was higher in young apoE-/- mice than in age-matched C57 mice, and reactive oxygen species were increased in aged C57 and apoE-/- mice. Superoxides 23-33 apolipoprotein E Mus musculus 97-101 25398022-9 2014 Immunoreactivity of the catalytic subunit of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, Nox2, and superoxide were elevated in ApoE-/- mice that were fed the low n-3 PUFA diet, and this was also significantly attenuated in mice that were fed the high n-3 PUFA diet. Superoxides 116-126 apolipoprotein E Mus musculus 144-148 23981672-5 2013 RESULTS: MNC from apoE(-/-) vehicle exhibited a 2-fold increase in production of superoxide anion in comparison with WT. Superoxides 81-97 apolipoprotein E Mus musculus 18-22 23981672-6 2013 In contrast, sildenafil-administered apoE(-/-) mice showed superoxide anion levels similar to those observed in WT mice. Superoxides 59-75 apolipoprotein E Mus musculus 37-41 23958265-7 2013 Basal generation of superoxide was increased 1.55 fold (P = 0.01) in endothelial cells from ApoE(-/-)/ESMIRO mice and was inhibited by the NADPH oxidase inhibitor gp91ds-tat (-12 +- 0.04%, P = 0.04), the NO synthase inhibitor L-NMMA (-8 +- 0.02%, P = 0.001) and the mitochondrial specific inhibitor rotenone (-23 +- 0.04%, P = 0.006). Superoxides 20-30 apolipoprotein E Mus musculus 92-96 23981672-8 2013 CONCLUSIONS: ApoE(-/-) mice chronically administered with sildenafil exhibited reduced levels of superoxide anion in MNC and less DNA fragmentation in MNC and liver cells, which are biomarkers of genotoxicity. Superoxides 97-113 apolipoprotein E Mus musculus 13-17 22287576-4 2012 Endothelial overexpression of Nox2 in ApoE(-/-) mice did not alter blood pressure, but significantly increased vascular superoxide production compared with ApoE(-/-) littermates, measured using both lucigenin chemiluminescence and 2-hydroxyethidium production (ApoE(-/-), 19.9 +- 6.3 vs. Nox2-Tg ApoE(-/-), 47.0 +- 7.0 nmol 2-hydroxyethidium/aorta, P< 0.05). Superoxides 120-130 apolipoprotein E Mus musculus 38-42 22580124-4 2012 Partially ligated ApoE knockout mice, a more physiologically relevant model of low and oscillatory flow, developed an advanced lesion in 2 weeks, and orally administered 8-OHdG significantly reduced plaque formation along with reduced superoxide formation, monocyte/macrophage infiltration, and extracellular matrix (ECM) accumulation. Superoxides 235-245 apolipoprotein E Mus musculus 18-22 22287576-7 2012 CONCLUSION: Endothelial-targeted Nox2 overexpression in ApoE(-/-) mice is sufficient to increase vascular superoxide production and increase macrophage recruitment possible via activation of endothelial cells. Superoxides 106-116 apolipoprotein E Mus musculus 56-60 21803947-6 2011 Compared with WT-HFD mice, ApoE(-/-)-HFD mice displayed an increase in total plasma cholesterol levels (P < 0.001), vascular (P < 0.05) and platelet (P < 0.05) superoxide (O(2)( -)) production, and reduced endogenous NO( ) bioavailability (P < 0.001). Superoxides 169-179 apolipoprotein E Mus musculus 27-31 22291917-10 2012 CONCLUSION: Overt plaque formation, increased vascular inflammation and L/E- interactions are associated with significant reduction of superoxide production in apoE(-/-)/eNOS(-/-) vessels. Superoxides 135-145 apolipoprotein E Mus musculus 160-164 21474820-5 2011 IL17A/ApoE(-/-) mice had reduced aortic superoxide production, increased aortic nitric oxide levels, decreased aortic leukocyte and dendritic cell infiltration, and reduced weight gain after a high-fat diet compared with ApoE(-/-) mice. Superoxides 40-50 apolipoprotein E Mus musculus 6-10 21896159-6 2011 ApoE KO-MNC mice also have reduced production of superoxide anions and increased eNOS expression compared to apoE KO mice. Superoxides 49-66 apolipoprotein E Mus musculus 0-4 20511416-8 2010 In the aortic wall, superoxide production was enhanced and NO-dependent relaxation diminished in apoE(-/-) x TGFbeta(1) mice but improved significantly after apocynin or SOD. Superoxides 20-30 apolipoprotein E Mus musculus 97-101 19189960-8 2009 Dextromethorphan treatment (10-40 mg/kg/day) for 10 weeks in apoE-deficient mice significantly reduced superoxide production in their polymorphonuclear leukocytes and aortas. Superoxides 103-113 apolipoprotein E Mus musculus 61-65 16873728-6 2006 In carotid artery, superoxide was increased (67+/-5.2 relative fluorescence intensity/vessel area [RI] in apoe/sod2 mice, 31+/-3.1 RI in apoE/SOD2 mice, P<0.05), and relaxation to acetylcholine was impaired in apoe/sod2 mice versus apoe/ SOD2, apoE/sod2, apoE/SOD2 mice. Superoxides 19-29 apolipoprotein E Mus musculus 106-110 17463333-2 2007 We have shown that the atherosclerotic lesion size was augmented in apolipoprotein E-deficient (ApoE-KO) mice overexpressing eNOS because of the enhanced superoxide production. Superoxides 154-164 apolipoprotein E Mus musculus 96-100 18344628-1 2007 Elevated superoxide formation in cardiac extracts of apolipoprotein E-knockout (apoE-KO) mice has been reported. Superoxides 9-19 apolipoprotein E Mus musculus 53-69 18344628-1 2007 Elevated superoxide formation in cardiac extracts of apolipoprotein E-knockout (apoE-KO) mice has been reported. Superoxides 9-19 apolipoprotein E Mus musculus 80-84 17070425-11 2006 Amlodipine treatment in HCD-fed ApoE KO mice also reduced superoxide production in the ischemic area of the brain. Superoxides 58-68 apolipoprotein E Mus musculus 32-36 16873728-6 2006 In carotid artery, superoxide was increased (67+/-5.2 relative fluorescence intensity/vessel area [RI] in apoe/sod2 mice, 31+/-3.1 RI in apoE/SOD2 mice, P<0.05), and relaxation to acetylcholine was impaired in apoe/sod2 mice versus apoe/ SOD2, apoE/sod2, apoE/SOD2 mice. Superoxides 19-29 apolipoprotein E Mus musculus 137-141 16873728-6 2006 In carotid artery, superoxide was increased (67+/-5.2 relative fluorescence intensity/vessel area [RI] in apoe/sod2 mice, 31+/-3.1 RI in apoE/SOD2 mice, P<0.05), and relaxation to acetylcholine was impaired in apoe/sod2 mice versus apoe/ SOD2, apoE/sod2, apoE/SOD2 mice. Superoxides 19-29 apolipoprotein E Mus musculus 213-217 16873728-6 2006 In carotid artery, superoxide was increased (67+/-5.2 relative fluorescence intensity/vessel area [RI] in apoe/sod2 mice, 31+/-3.1 RI in apoE/SOD2 mice, P<0.05), and relaxation to acetylcholine was impaired in apoe/sod2 mice versus apoe/ SOD2, apoE/sod2, apoE/SOD2 mice. Superoxides 19-29 apolipoprotein E Mus musculus 213-217 16873728-6 2006 In carotid artery, superoxide was increased (67+/-5.2 relative fluorescence intensity/vessel area [RI] in apoe/sod2 mice, 31+/-3.1 RI in apoE/SOD2 mice, P<0.05), and relaxation to acetylcholine was impaired in apoe/sod2 mice versus apoe/ SOD2, apoE/sod2, apoE/SOD2 mice. Superoxides 19-29 apolipoprotein E Mus musculus 247-251 16873728-6 2006 In carotid artery, superoxide was increased (67+/-5.2 relative fluorescence intensity/vessel area [RI] in apoe/sod2 mice, 31+/-3.1 RI in apoE/SOD2 mice, P<0.05), and relaxation to acetylcholine was impaired in apoe/sod2 mice versus apoe/ SOD2, apoE/sod2, apoE/SOD2 mice. Superoxides 19-29 apolipoprotein E Mus musculus 247-251 16873728-8 2006 In aorta, superoxide levels were increased and relaxation to acetylcholine was impaired in apoe/sod2 and apoe/SOD2 mice, but responses were similar in apoe/sod2 and apoe/SOD2 mice. Superoxides 10-20 apolipoprotein E Mus musculus 105-109 16873728-8 2006 In aorta, superoxide levels were increased and relaxation to acetylcholine was impaired in apoe/sod2 and apoe/SOD2 mice, but responses were similar in apoe/sod2 and apoe/SOD2 mice. Superoxides 10-20 apolipoprotein E Mus musculus 105-109 16873728-8 2006 In aorta, superoxide levels were increased and relaxation to acetylcholine was impaired in apoe/sod2 and apoe/SOD2 mice, but responses were similar in apoe/sod2 and apoe/SOD2 mice. Superoxides 10-20 apolipoprotein E Mus musculus 105-109 14707037-5 2004 Compared with ApoE-KO controls, transgenic mice (ApoE-KO/GCH-Tg) had higher aortic BH4 levels, reduced endothelial superoxide production and eNOS uncoupling, increased cGMP levels, and preserved NO-mediated endothelium dependent vasorelaxations. Superoxides 115-125 apolipoprotein E Mus musculus 49-53 16403692-9 2005 Aortic superoxide production and the extent of atherosclerotic lesions were greater in ApoE(-)/(-) mice on a normal-salt diet compared with C57Bl/6. Superoxides 7-17 apolipoprotein E Mus musculus 87-91 16584925-4 2006 O2*- measured ex vivo by L-012-enhanced chemiluminescence was increased by 79+/-17% in whole sympathetic ganglia from apoE-/- mice (n=5) compared with sympathetic ganglia from control mice (n=5) (P<0.05). Superoxides 0-3 apolipoprotein E Mus musculus 118-122 16584925-6 2006 Dihydroethidium staining confirmed the selective increase in O2*- in sympathetic ganglia of apoE-/- mice, and revealed the contribution of both neurons and non-neuronal cells to the O2*- generation. Superoxides 61-63 apolipoprotein E Mus musculus 92-96 16584925-7 2006 We investigated the enzymatic source of increased O2*- in sympathetic ganglia of apoE-/- mice. Superoxides 50-52 apolipoprotein E Mus musculus 81-85 15613778-9 2004 However, in eNOS-transgenic mice (eNOS-Tg) crossbred with apolipoprotein E-deficient mice (apoE-KO/eNOS-Tg), we found the accelerated lesion formation in association with increased superoxide production from vessels compared with apoE-KO mice. Superoxides 181-191 apolipoprotein E Mus musculus 91-95 15277329-6 2004 Concomitantly, aortic release of superoxide radicals was increased 2-fold in ApoE-/- mice compared with wild-type animals, whereas aortic superoxide production was normalized in ApoE-/--AT1-/- mice (L-012 chemiluminescence). Superoxides 33-43 apolipoprotein E Mus musculus 77-81 15277329-6 2004 Concomitantly, aortic release of superoxide radicals was increased 2-fold in ApoE-/- mice compared with wild-type animals, whereas aortic superoxide production was normalized in ApoE-/--AT1-/- mice (L-012 chemiluminescence). Superoxides 138-148 apolipoprotein E Mus musculus 178-182 12871831-10 2003 In aortae from apolipoprotein(E)-deficient mice (apoE(0)) with hyperlipidemia and atherosclerosis, superoxide production is largely derived from NADPH oxidase. Superoxides 99-109 apolipoprotein E Mus musculus 15-32 12902640-7 2003 The endothelial dysfunction in apoE(0) mice is associated with hyperlipidemia and increased vascular oxidative stress measured as increased superoxide production. Superoxides 140-150 apolipoprotein E Mus musculus 31-35 12044962-7 2002 In addition, ApoE(-/-) mice fed the calorie-restricted diet showed a significant decrease in the level of lipid hydroperoxides and the production of superoxide and hydrogen peroxide in the aorta as compared to ApoE(-/-) mice fed AL. Superoxides 149-159 apolipoprotein E Mus musculus 13-17 34320345-8 2021 Conversely, AGXT overexpression in Apoe-/- mice increases the glycine/oxalate ratio and decreases aortic superoxide, CCL5, and atherosclerosis. Superoxides 105-115 apolipoprotein E Mus musculus 35-39 11744035-11 2002 In line with this finding the NADPH induced O(2)(-) formation was enhanced in cardiac extracts from apoE-/- hearts. Superoxides 44-49 apolipoprotein E Mus musculus 100-104 11744035-12 2002 CONCLUSION: apoE-/- hearts develop a hemodynamically relevant endothelial dysfunction at the level of coronary resistance vessels most likely via inactivation of bioavailable NO by superoxide anions. Superoxides 181-198 apolipoprotein E Mus musculus 12-16 11397713-4 2001 By use of confocal microscopy of an oxidative fluorescent probe (dihydroethidium), increased superoxide anion (O(2)(-)) production was demonstrated throughout the aortic wall but mainly in smooth muscle cells of apoE-deficient mice. Superoxides 93-109 apolipoprotein E Mus musculus 212-216 11397713-4 2001 By use of confocal microscopy of an oxidative fluorescent probe (dihydroethidium), increased superoxide anion (O(2)(-)) production was demonstrated throughout the aortic wall but mainly in smooth muscle cells of apoE-deficient mice. Superoxides 111-118 apolipoprotein E Mus musculus 212-216 11397713-9 2001 Our results demonstrate that in apoE-deficient mice on a Western-type fat diet, impairment of endothelial function is caused by increased production of O(2)(-) and reduced endothelial NO synthase enzyme activity. Superoxides 152-156 apolipoprotein E Mus musculus 32-36 32401607-7 2020 After 12 wk Western diet, ESMIRO/ApoE-/-/Nox2-/y mice had reduced EC superoxide generation and greater aortic relaxation to acetylcholine. Superoxides 69-79 apolipoprotein E Mus musculus 33-37