PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11789672-9 2002 When IL-8 was added to cultured granulocytes, the levels of CD18 expression on granulocytes and superoxide anion production by granulocytes were significantly increased. Superoxides 96-112 C-X-C motif chemokine ligand 8 Homo sapiens 5-9 11495082-9 2001 The concentrations of recombinant (r)-IL-8, which covered the levels of activity detected in individual organ cultures or cell cultures of fractionated mucosal cells, could induce chemotactic migration and superoxide anion generation in neutrophils in vitro, and r-GROalpha had synergistic effects on r-IL-8-induced neutrophil activation. Superoxides 206-222 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 11358991-2 2001 Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood. Superoxides 76-86 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 11358991-2 2001 Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood. Superoxides 76-86 C-X-C motif chemokine ligand 8 Homo sapiens 121-125 10921280-6 2000 Acute exposure to cigarette smoke initiates a superoxide-dependent mechanism that, through NF-kappa B activation and IL-8 expression, induces infiltration of neutrophils into the airways in vivo. Superoxides 46-56 C-X-C motif chemokine ligand 8 Homo sapiens 117-121 10744650-7 2000 Cap formation and superoxide anion production induced by solid-phase P-selectin or by IL-8 and soluble rP-selectin treatment were inhibited by treatment of the leukocytes with cytochalasin B. Superoxides 18-34 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 10725748-7 2000 In the same cells, IL-8 also caused superoxide release. Superoxides 36-46 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 10101223-10 1999 Neutrophils activation of phospholipase D (PLD) and superoxide generation in response to IL-8 have also been demonstrated. Superoxides 52-62 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 9820546-2 1998 Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood. Superoxides 90-100 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 9820546-2 1998 Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood. Superoxides 90-100 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 9820546-6 1998 Combination of the NO-generating chemicals with a superoxide-generating system (xanthine/xanthine oxidase) markedly increased IL-8 release. Superoxides 50-60 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 9366432-3 1997 Other IL-8-induced biologic functions, such as superoxide generation, intracellular Ca2+ mobilization, and enzyme release were also reduced in hamycin-treated cells by 50 to 75%. Superoxides 47-57 C-X-C motif chemokine ligand 8 Homo sapiens 6-10 9245487-7 1997 With respect to control, IL-8 induced biological responses e.g. IL-8 directed migration, intracellular Ca2+ release and superoxide release are significantly reduced by 77%, 94% and 76%, respectively, in presence of MDC. Superoxides 120-130 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 9268748-8 1997 Preincubation on normal neutrophils with the patients" sera caused an increase in their superoxide generation in accordance with the high IL-8 levels in these sera. Superoxides 88-98 C-X-C motif chemokine ligand 8 Homo sapiens 138-142 9215025-0 1997 Effect of exogenous nitric oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes. Superoxides 37-47 C-X-C motif chemokine ligand 8 Homo sapiens 51-64 9215025-9 1997 Nitric oxide and superoxide have profound effects on IL-8. Superoxides 17-27 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 9179547-1 1997 Superoxide release in neutrophils and sera levels of interleukin 8 (IL-8) were determined in 15 patients with complicated acute myocardial infarction (MI) and 15 patients with uncomplicated MI. Superoxides 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 8989903-3 1997 Increase in O2(-)-producing capacity in MPD was also observed when other receptor-mediated agonists such as interleukin-8 and concanavalin A were used, but not when phorbol ester, a direct activator of protein kinase C, was used as the triggering agonist of O2- release. Superoxides 12-14 C-X-C motif chemokine ligand 8 Homo sapiens 108-121 8989903-3 1997 Increase in O2(-)-producing capacity in MPD was also observed when other receptor-mediated agonists such as interleukin-8 and concanavalin A were used, but not when phorbol ester, a direct activator of protein kinase C, was used as the triggering agonist of O2- release. Superoxides 258-260 C-X-C motif chemokine ligand 8 Homo sapiens 108-121 8810307-1 1996 The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78). Superoxides 40-50 C-X-C motif chemokine ligand 8 Homo sapiens 119-132 8810307-1 1996 The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78). Superoxides 40-50 C-X-C motif chemokine ligand 8 Homo sapiens 134-138 8810307-1 1996 The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78). Superoxides 52-55 C-X-C motif chemokine ligand 8 Homo sapiens 119-132 8810307-1 1996 The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78). Superoxides 52-55 C-X-C motif chemokine ligand 8 Homo sapiens 134-138 8692878-7 1996 Superoxide production, a measure of the respiratory burst, was obtained with increasing concentrations of IL-8 with maximum effects at 25 to 50 nM, but no response was observed upon challenge with GRO alpha or NAP-2 up to 1000 nM. Superoxides 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 8692878-8 1996 The superoxide production induced by IL-8 was inhibited by anti-IL8R1, but was not affected by anti-IL8R2. Superoxides 4-14 C-X-C motif chemokine ligand 8 Homo sapiens 37-41 8605000-2 1996 Interleukin-8 triggers several functions of neutrophils in host defense: chemotaxis, degranulation and enzyme release, and superoxide production. Superoxides 123-133 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 7790770-6 1995 However, neutrophils pretreated with interleukin-8 ingested IgA-opsonized microspheres and released superoxide when exposed to IgA antibody-antigen complexes. Superoxides 100-110 C-X-C motif chemokine ligand 8 Homo sapiens 37-50 7738357-0 1995 Interleukin-8 and GRO alpha prime human neutrophils for superoxide anion production and induce up-regulation of N-formyl peptide receptors. Superoxides 56-72 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 7738357-6 1995 This study indicates that IL-8 and GRO alpha, in addition to their known chemotactic activity, prime neutrophils for superoxide anion production, presumably by up-regulating the number of receptors for strong superoxide-anion-triggering stimuli. Superoxides 117-133 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 7738357-6 1995 This study indicates that IL-8 and GRO alpha, in addition to their known chemotactic activity, prime neutrophils for superoxide anion production, presumably by up-regulating the number of receptors for strong superoxide-anion-triggering stimuli. Superoxides 209-225 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 7525817-5 1994 For example, treatments of neutrophils with interleukin-8 (IL-8) or granulocyte colony-stimulating factor (G-CSF) potentiated the P-selectin-induced O2- production. Superoxides 149-151 C-X-C motif chemokine ligand 8 Homo sapiens 44-57 7525817-5 1994 For example, treatments of neutrophils with interleukin-8 (IL-8) or granulocyte colony-stimulating factor (G-CSF) potentiated the P-selectin-induced O2- production. Superoxides 149-151 C-X-C motif chemokine ligand 8 Homo sapiens 59-63 7818993-3 1994 AFC-ME, but not AFC, inhibited NaF- and PMA-stimulated superoxide release. Superoxides 55-65 C-X-C motif chemokine ligand 8 Homo sapiens 31-34 8120414-9 1994 This study indicates that IL-8 is a potent activator of intracellular events presumably required for chemotaxis, but a relatively weak activator for events associated with superoxide anion generation and proinflammatory activity. Superoxides 172-188 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 7735949-8 1994 Therefore, ET-1-treated monocytes probably upregulate neutrophil superoxide production via a mechanism which includes IL-8. Superoxides 65-75 C-X-C motif chemokine ligand 8 Homo sapiens 118-122 8281849-6 1994 At the cellular level, 5-aminosalicylic acid inhibited phorbol myristate acetate (100 ng/ml)-activated superoxide generation to 82.3 +/- 9.3%, the formylmethionyl leucyl peptide (10(-5) M) to 61.0 +/- 6.8%, and the NaF (20 mM)-stimulated production to 32.3 +/- 3.2% (mean +/- SD, P < 0.01). Superoxides 103-113 C-X-C motif chemokine ligand 8 Homo sapiens 215-218 8123758-10 1993 This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production. Superoxides 54-64 C-X-C motif chemokine ligand 8 Homo sapiens 101-105 8123758-10 1993 This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production. Superoxides 54-64 C-X-C motif chemokine ligand 8 Homo sapiens 174-178 8406585-0 1993 Interleukin-8 primes human neutrophils for enhanced superoxide anion production. Superoxides 52-68 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 8406585-2 1993 In this study, we investigated the effect of recombinant human (rh) IL-8 on superoxide (O2-) production by neutrophils. Superoxides 76-86 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 8406585-2 1993 In this study, we investigated the effect of recombinant human (rh) IL-8 on superoxide (O2-) production by neutrophils. Superoxides 88-90 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 8406585-5 1993 Recombinant human IL-8 increased both the maximal rate and the total O2- production, but did not prolong the response to FMLP. Superoxides 69-71 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 8382247-2 1993 NaF and FMLP stimulated superoxide release from both groups of cells, but the response was attenuated in RA-differentiated cells. Superoxides 24-34 C-X-C motif chemokine ligand 8 Homo sapiens 0-3 18475524-3 1993 Neither inhibitor affected the upregulation of CD11b beta(2)-integrin expression or priming of superoxide generation stimulated by IL-8 and GM-CSF. Superoxides 95-105 C-X-C motif chemokine ligand 8 Homo sapiens 131-135 1529797-1 1992 Interleukin-8 (IL-8), is a potent activator of polymorphonuclear leukocyte (PMN) functions including chemotaxis, superoxide anion production, and enzyme release and it is also chemotactic for lymphocytes. Superoxides 113-129 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 1529797-1 1992 Interleukin-8 (IL-8), is a potent activator of polymorphonuclear leukocyte (PMN) functions including chemotaxis, superoxide anion production, and enzyme release and it is also chemotactic for lymphocytes. Superoxides 113-129 C-X-C motif chemokine ligand 8 Homo sapiens 15-19 1309871-3 1992 Moreover, postreceptor stimulation of superoxide production by NaF (a G protein activator), but not by phorbol myristate acetate, was significantly inhibited by SC-41930, indicating that SC-41930 may act via attenuation of a G protein-mediated signal transduction. Superoxides 38-48 C-X-C motif chemokine ligand 8 Homo sapiens 63-66 1663497-2 1991 Diazepam also inhibited the superoxide production induced by FMLP, NaF, and A23187, but not that induced by PMA whose stimulant action was insensitive even to 10(-4) M diazepam. Superoxides 28-38 C-X-C motif chemokine ligand 8 Homo sapiens 67-70 1653806-13 1991 Cyclosporines partially inhibited O2- formations induced by NaF and gamma-hexachlorocyclohexane. Superoxides 34-36 C-X-C motif chemokine ligand 8 Homo sapiens 60-63 1703410-6 1991 O2- formation stimulated by complement C5a, concanavalin A, NaF, A 23187, phorbol myristate acetate and arachidonic acid was not affected by Bt2cCMP. Superoxides 0-2 C-X-C motif chemokine ligand 8 Homo sapiens 60-63 2170531-5 1990 Pretreatment of neutrophils with either GM-CSF or TNF-alpha dose-dependently enhanced the production of superoxide induced by NaF, as determined by the superoxide dismutase-inhibitable reduction of ferricytochrome c. Superoxides 104-114 C-X-C motif chemokine ligand 8 Homo sapiens 126-129 1966131-0 1990 Production of superoxide anion and hydrogen peroxide by human neutrophilic granulocytes during chemotactic migration towards f-Met-Leu-Phe, C5a, leukotriene B4, monocyte-derived chemotaxin/IL-8 and platelet-activating factor. Superoxides 14-30 C-X-C motif chemokine ligand 8 Homo sapiens 189-193 3322281-4 1987 Crude and pure NAF stimulated human neutrophils to release granule enzymes and to produce superoxide and H2O2. Superoxides 90-100 C-X-C motif chemokine ligand 8 Homo sapiens 15-18 2824608-4 1987 Purified MONAP stimulate human neutrophil chemotaxis at an estimated molarity of 5 x 10(-11) M. Half-maximal enzyme release of cytochalasin B pretreated neutrophils occurred at 2 to 3 x 10(-10) M, whereas superoxide anion production elicited by various concentrations of MONAP was found to be low. Superoxides 205-221 C-X-C motif chemokine ligand 8 Homo sapiens 9-14 2985653-9 1985 Preincubation of neutrophils with NAF resulted in greater release of superoxide anion upon their subsequent stimulation by either bacterial phagocytosis or by phorbol myristate acetate, as compared with control neutrophils stimulated in a like manner. Superoxides 69-85 C-X-C motif chemokine ligand 8 Homo sapiens 34-37 207727-5 1978 Superoxide anion production correlated closely with CL responses in NaF-treated human PMNs. Superoxides 0-16 C-X-C motif chemokine ligand 8 Homo sapiens 68-71 32315368-2 2020 The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, forming platelet-neutrophil aggregates that are increased in individuals with active UC, hence an index of both cells could produce a monitoring tool. Superoxides 166-176 C-X-C motif chemokine ligand 8 Homo sapiens 66-79 32315368-2 2020 The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, forming platelet-neutrophil aggregates that are increased in individuals with active UC, hence an index of both cells could produce a monitoring tool. Superoxides 166-176 C-X-C motif chemokine ligand 8 Homo sapiens 81-85 31052583-8 2019 NM-200 induced production of IL-8, a potent attractor and activator of neutrophils, growth factors (VEGF and IGF-1) and superoxide. Superoxides 120-130 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 24174716-3 2013 These bacterial species initiate the production of various cytokines such as interleukin-8 and TNF-alpha, further causing an increase in number and activity of polymorphonucleocytes (PMN) along with these cytokines, PMNs also produce reactive oxygen species (ROS) superoxide via the respiratory burst mechanism as the part of the defence response to infection. Superoxides 264-274 C-X-C motif chemokine ligand 8 Homo sapiens 77-90 22634165-9 2012 Our results showed that splitomicin inhibited superoxide anion production by fMLP (1 muM) and NaF (20mM) in a concentration-dependent manner (37.5-450 muM). Superoxides 46-62 C-X-C motif chemokine ligand 8 Homo sapiens 94-97 22392142-0 2012 NADPH oxidase-derived superoxide destabilizes lipopolysaccharide-induced interleukin 8 mRNA via p38, extracellular signal-regulated kinase mitogen-activated protein kinase, and the destabilizing factor tristetraprolin. Superoxides 22-32 C-X-C motif chemokine ligand 8 Homo sapiens 73-86 22627375-4 2012 We have observed that in the absence of eosinophil chemoattractants, neutrophils stimulated by IL-8 augment eosinophil trans-basement membrane migration by releasing superoxide anion, matrix metalloproteinase, leukotriene B(4) and platelet-activating factor. Superoxides 166-182 C-X-C motif chemokine ligand 8 Homo sapiens 95-99 21352551-6 2011 Peak respiratory burst activity was seen at 15-20 min, and superoxide levels returned to baseline by 1 h. IL-8 release was dependent on both membrane-associated CD14 (mCD14) and Toll-like receptor 4 (TLR4. Superoxides 59-69 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 20920494-5 2011 LPS-induced ICAM-1 and IL-8 expression was associated with increased superoxide formation in AEC. Superoxides 69-79 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 20397192-0 2010 Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Superoxides 99-115 C-X-C motif chemokine ligand 8 Homo sapiens 52-65 20397192-7 2010 The most important mechanism by which MG and GL induced IL-8 secretion was the generation of superoxide anions which was confirmed by the inhibition of the cytosolic NADPH oxidase with diphenyl iodonium (DPI) or by application of superoxide dismutase (SOD). Superoxides 93-110 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 20397192-8 2010 Our data suggest that multiple pathways were simultaneously activated; however, superoxide dependent MAPK p38 activation seems to be the most dominant pathway for IL-8 secretion in intestinal cells. Superoxides 80-90 C-X-C motif chemokine ligand 8 Homo sapiens 163-167 19740380-9 2009 Superoxide release from neutrophils was measured by the reduction of ferricytochrome C, degranulation by the conversion of a synthetic colour substrate, cytokine release by interleukin-8 enzyme-linked immunosorbent assay, and adhesion by a flow-based adhesion assay. Superoxides 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 173-186 18292390-9 2008 Finally, human macrophages acquire responsiveness to the CXCR2 ligands (IL-8 and Grobeta), as measured by superoxide anion production, after induction of CXCR2 expression by PPAR-gamma ligands. Superoxides 106-122 C-X-C motif chemokine ligand 8 Homo sapiens 72-88 17541276-12 2007 Finally, theophylline attenuated the superoxide anion generation from IL-8-stimulated neutrophils on the Matrigel-coated plates. Superoxides 37-53 C-X-C motif chemokine ligand 8 Homo sapiens 70-74 17002793-9 2006 These cytokines have previously been shown to independently regulate the frequency (IFN-gamma) and amplitude (IL-8) of the oscillations of key metabolites in neutrophils, including nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and superoxide ion. Superoxides 241-251 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 16214039-10 2005 Sublethal superoxide dose evoked: (1) proinflammatory state manifested by increased IL-8 mRNA expression and CAM on the endothelial surface, (2) HUVEC apoptosis and activated endothelial NADPH oxidase, (3) increase in intracellular tissue factor, and (4) decrease in eNOS mRNA and protein and up-regulation of iNOS mRNA. Superoxides 10-20 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 15147563-2 2004 Here we show that triggering of the formyl peptide receptor (FPR) with f-Met-Leu-Phe (fMLF) substantially reduced the neutrophil superoxide production induced by activation of the CXC receptors with IL-8. Superoxides 129-139 C-X-C motif chemokine ligand 8 Homo sapiens 199-203 12960242-7 2003 Neutrophils spontaneously produced NO whose production was not increased, but rather decreased by nicotine stimulation, suggesting that superoxide, produced by nicotine, generates peroxynitrite by reacting with preformed NO, which enhances the NF-kappaB activity, thereby producing IL-8. Superoxides 136-146 C-X-C motif chemokine ligand 8 Homo sapiens 282-286 12626343-1 2003 Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes. Superoxides 42-52 C-X-C motif chemokine ligand 8 Homo sapiens 140-158