PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22041456-0 2012 Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(- ) and H2O2. Superoxides 94-96 succinate dehydrogenase complex subunit D Homo sapiens 38-71 22041456-0 2012 Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(- ) and H2O2. Superoxides 94-96 succinate dehydrogenase complex subunit D Homo sapiens 73-77 22041456-3 2012 Stable expression of mutant SDHD resulted in 2-fold increases in steady-state levels of superoxide that were accompanied by a significantly increased mutation rate as well as a 70-fold increase in mutation frequency at the hprt locus. Superoxides 88-98 succinate dehydrogenase complex subunit D Homo sapiens 28-32 22041456-7 2012 These results demonstrate that mutations in SDHD cause increased steady-state levels of superoxide which significantly contributed to increases in mutation rates and frequency mediated by superoxide and hydrogen peroxide. Superoxides 88-98 succinate dehydrogenase complex subunit D Homo sapiens 44-48 22041456-7 2012 These results demonstrate that mutations in SDHD cause increased steady-state levels of superoxide which significantly contributed to increases in mutation rates and frequency mediated by superoxide and hydrogen peroxide. Superoxides 188-198 succinate dehydrogenase complex subunit D Homo sapiens 44-48