PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19540523-12 2009 Furthermore, HIV Nef significantly increased superoxide anion production in porcine pulmonary arteries and HPAECs compared with controls (P < 0.05). Superoxides 45-61 S100 calcium binding protein B Homo sapiens 17-20 29938962-5 2016 However, only the region containing FPDW 121-124 on Nef is able to induce superoxide production. Superoxides 74-84 S100 calcium binding protein B Homo sapiens 52-55 20053941-9 2010 Neutrophils from people with poorly controlled diabetes and in vitro incubation of neutrophils with high glucose and the receptor for advanced glycation end products ligand S100B greatly enhanced superoxide generation compared with controls, and this was significantly inhibited by BEL. Superoxides 196-206 S100 calcium binding protein B Homo sapiens 173-178 20392440-2 2010 It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be secondary to a direct effect of Nef on components of the NADPH oxidase complex. Superoxides 76-86 S100 calcium binding protein B Homo sapiens 27-30 20392440-2 2010 It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be secondary to a direct effect of Nef on components of the NADPH oxidase complex. Superoxides 76-86 S100 calcium binding protein B Homo sapiens 238-241 20392440-2 2010 It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be secondary to a direct effect of Nef on components of the NADPH oxidase complex. Superoxides 132-142 S100 calcium binding protein B Homo sapiens 27-30 20392440-2 2010 It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be secondary to a direct effect of Nef on components of the NADPH oxidase complex. Superoxides 132-142 S100 calcium binding protein B Homo sapiens 238-241 20392440-3 2010 In this work, we describe that Nef, was capable of increasing superoxide production in human neutrophils. Superoxides 62-72 S100 calcium binding protein B Homo sapiens 31-34 15847608-0 2005 HIV-1 Nef regulates the release of superoxide anions from human macrophages. Superoxides 35-52 S100 calcium binding protein B Homo sapiens 6-9 19130504-0 2009 HIV-1 Nef induces p47(phox) phosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line. Superoxides 63-79 S100 calcium binding protein B Homo sapiens 6-9 19130504-3 2009 We have recently shown that the inducible expression of HIV-1 Nef in human macrophages cell line modulates in bi-phasic mode the superoxide anion release by NADPH oxidase, inducing a fast increase of the superoxide production, followed by a delayed strong inhibition mediated by Nef-induced soluble factor(s). Superoxides 129-145 S100 calcium binding protein B Homo sapiens 279-282 19130504-3 2009 We have recently shown that the inducible expression of HIV-1 Nef in human macrophages cell line modulates in bi-phasic mode the superoxide anion release by NADPH oxidase, inducing a fast increase of the superoxide production, followed by a delayed strong inhibition mediated by Nef-induced soluble factor(s). Superoxides 129-139 S100 calcium binding protein B Homo sapiens 279-282 19130504-4 2009 Our study is focused on the molecular mechanisms involved in Nef-mediated activation of NADPH oxidase and superoxide anion release. Superoxides 106-122 S100 calcium binding protein B Homo sapiens 61-64 19130504-5 2009 Using U937 cells stably transfected with different Nef alleles, we found that both Nef membrane localization and intact SH3-binding domain are needed to induce superoxide release. Superoxides 160-170 S100 calcium binding protein B Homo sapiens 51-54 19130504-5 2009 Using U937 cells stably transfected with different Nef alleles, we found that both Nef membrane localization and intact SH3-binding domain are needed to induce superoxide release. Superoxides 160-170 S100 calcium binding protein B Homo sapiens 83-86 19130504-6 2009 The lack of effect during treatment with a specific MAPK pathway inhibitor, PD98059, demonstrated that Nef-induced superoxide release is independent of Erk1/2 phosphorylation. Superoxides 115-125 S100 calcium binding protein B Homo sapiens 103-106 18390927-8 2008 HL-60 cells cultured in HG and S100B exhibited a 1.8-fold increase in fMLP-induced superoxide generation compared with those cultured in normal glucose (5.5 mM). Superoxides 83-93 S100 calcium binding protein B Homo sapiens 31-36 17327432-8 2007 LR-90 also prevented oxidative stress in activated monocytes, as demonstrated by its inhibitory effects on S100b-induced expression of NADPH oxidase and intracellular superoxide production. Superoxides 167-177 S100 calcium binding protein B Homo sapiens 107-112 15847608-4 2005 We show here that the inducible expression of Nef in human phagocytic cells modulates the superoxide release in a biphasic manner. Superoxides 90-100 S100 calcium binding protein B Homo sapiens 46-49 15847608-5 2005 In particular, an early Nef-induced increase of the superoxide release was followed by a dramatic decrease starting from 10 h after the Nef induction. Superoxides 52-62 S100 calcium binding protein B Homo sapiens 24-27 15847608-5 2005 In particular, an early Nef-induced increase of the superoxide release was followed by a dramatic decrease starting from 10 h after the Nef induction. Superoxides 52-62 S100 calcium binding protein B Homo sapiens 136-139 15847608-7 2005 Whereas the early increase in superoxide release is probably the result of the already described Nef-dependent activation of PAK-2 (p21-activated kinase 2)-Rac2, we were interested in investigating the mechanisms underlying the late inhibition of superoxide release observed originally. Superoxides 30-40 S100 calcium binding protein B Homo sapiens 97-100 15847608-8 2005 In this regard, we individuated at least three independent requirements for the Nef-induced blockade of superoxide release: (i) the active protein synthesis; (ii) both the membrane localization and the interaction with endocytotic machinery of Nef; and (iii) the release of soluble factor(s). Superoxides 104-114 S100 calcium binding protein B Homo sapiens 80-83 15847608-8 2005 In this regard, we individuated at least three independent requirements for the Nef-induced blockade of superoxide release: (i) the active protein synthesis; (ii) both the membrane localization and the interaction with endocytotic machinery of Nef; and (iii) the release of soluble factor(s). Superoxides 104-114 S100 calcium binding protein B Homo sapiens 244-247