PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20683758-7	2011	Significantly down-regulated expression levels of ZO-1, occludin and claudin-5 might be one of the molecular mechanisms of combining LFU and PA enhancing the permeability of BTB.	btb	174-177	claudin 5	Rattus norvegicus	69-78	
24523141-7	2014	This study demonstrates that combination of VEGF and PA can increase the permeability of the BTB by a paracellular pathway (downregulation of occludin and claudin-5) and a transcellular pathway (upregulation of caveolin-1 and caveolin-2) and that the cGMP/PKG/NF-kappaB signal pathway might be involved in the modulation process.	btb	93-96	claudin 5	Rattus norvegicus	155-164	
19326437-6	2009	BTB permeability increased in all the experimental groups, accompanied by opening of local TJ of the BTB, observed by transmission electron microscopy, and decreased mRNA and protein expressions of ZO-1, occludin, and claudin-5.	btb	0-3	claudin 5	Rattus norvegicus	218-227	
19326437-9	2009	The down-regulation of TJ-related proteins ZO-1, occludin, and claudin-5 may be one of the underlying mechanisms of the increase in BTB permeability induced by LFU and BK.	btb	132-135	claudin 5	Rattus norvegicus	63-72	
18183615-3	2008	In rat brain glioma model and BTB model in vitro, we find that the protein expression levels of ZO-1, occludin, and claudin-5 are attenuated by BK induction.	btb	30-33	claudin 5	Rattus norvegicus	116-125	
18183615-10	2008	This study demonstrates that the increase of BK-mediated BTB permeability is associated with the down-regulation of ZO-1, occludin, and claudin-5 and the rearrangement of F-actin and that cAMP/PKA signal transduction system might be involved in the modulating process.	btb	57-60	claudin 5	Rattus norvegicus	136-145