PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24896564-4 2014 We report here the first structure of the BTB domain of Keap1, which is thought to contain the key cysteine residue responsible for interaction with electrophiles, as well as structures of the covalent complex with the antagonist CDDO/bardoxolone, and of the constitutively inactive C151W BTB mutant. btb 42-45 kelch like ECH associated protein 1 Homo sapiens 56-61 31295462-4 2019 To confirm the molecular targets of new derivatives in NRf2 and NFkappaB pathways the docking at Kelch and BTB active sites of Keap1 as well as IKK was done. btb 107-110 kelch like ECH associated protein 1 Homo sapiens 127-132 28186440-7 2017 We report here the crystal structure of the complex of Britanin and the BTB domain of Keap1. btb 72-75 kelch like ECH associated protein 1 Homo sapiens 86-91 28186440-10 2017 The complex crystal structure of Britanin and the BTB domain of Keap1 help clarify the mechanism of Nrf2 induction. btb 50-53 kelch like ECH associated protein 1 Homo sapiens 64-69 24896564-4 2014 We report here the first structure of the BTB domain of Keap1, which is thought to contain the key cysteine residue responsible for interaction with electrophiles, as well as structures of the covalent complex with the antagonist CDDO/bardoxolone, and of the constitutively inactive C151W BTB mutant. btb 289-292 kelch like ECH associated protein 1 Homo sapiens 56-61 24896564-5 2014 In addition to providing the first structural confirmation of antagonist binding to Keap1 BTB, we also present biochemical evidence that adduction of Cys 151 by CDDO is capable of inhibiting the binding of Cul3 to Keap1, and discuss how this class of compound might exert Nrf2 activation through disruption of the BTB-Cul3 interface. btb 90-93 kelch like ECH associated protein 1 Homo sapiens 84-89 20027226-4 2009 A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein. btb 101-104 kelch like ECH associated protein 1 Homo sapiens 9-14 23847398-3 2013 The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains. btb 184-187 kelch like ECH associated protein 1 Homo sapiens 80-85 23847398-3 2013 The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains. btb 184-187 kelch like ECH associated protein 1 Homo sapiens 162-167 23847398-7 2013 The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures. btb 45-48 kelch like ECH associated protein 1 Homo sapiens 68-73 23847398-7 2013 The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures. btb 118-121 kelch like ECH associated protein 1 Homo sapiens 68-73 23349464-2 2013 Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single multidomain protein, of which the best known are BTB-BACK-Kelch domain proteins, including KEAP1. btb 60-63 kelch like ECH associated protein 1 Homo sapiens 254-259 20027226-4 2009 A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein. btb 101-104 kelch like ECH associated protein 1 Homo sapiens 115-120 15601839-6 2005 Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively. btb 30-33 kelch like ECH associated protein 1 Homo sapiens 48-53 15367669-2 2004 Nrf2 activity is opposed by the BTB/POZ domain protein Keap1. btb 32-35 kelch like ECH associated protein 1 Homo sapiens 55-60 15572695-6 2004 A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane. btb 101-104 kelch like ECH associated protein 1 Homo sapiens 9-14 15572695-6 2004 A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane. btb 101-104 kelch like ECH associated protein 1 Homo sapiens 115-120 35052618-3 2022 In the present study, we have identified that BAP1 deubiquitinates KEAP1 by binding to the BTB domain. btb 91-94 kelch like ECH associated protein 1 Homo sapiens 67-72