PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	9-14	
20027226-4	2009	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	9-14	
20027226-4	2009	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	115-120	
15601839-6	2005	Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively.	btb	30-33	kelch like ECH associated protein 1	Homo sapiens	48-53	
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	115-120	
15367669-2	2004	Nrf2 activity is opposed by the BTB/POZ domain protein Keap1.	btb	32-35	kelch like ECH associated protein 1	Homo sapiens	55-60	
35052618-3	2022	In the present study, we have identified that BAP1 deubiquitinates KEAP1 by binding to the BTB domain.	btb	91-94	kelch like ECH associated protein 1	Homo sapiens	67-72	
31295462-4	2019	To confirm the molecular targets of new derivatives in NRf2 and NFkappaB pathways the docking at Kelch and BTB active sites of Keap1 as well as IKK was done.	btb	107-110	kelch like ECH associated protein 1	Homo sapiens	127-132	
24896564-4	2014	We report here the first structure of the BTB domain of Keap1, which is thought to contain the key cysteine residue responsible for interaction with electrophiles, as well as structures of the covalent complex with the antagonist CDDO/bardoxolone, and of the constitutively inactive C151W BTB mutant.	btb	42-45	kelch like ECH associated protein 1	Homo sapiens	56-61	
28186440-7	2017	We report here the crystal structure of the complex of Britanin and the BTB domain of Keap1.	btb	72-75	kelch like ECH associated protein 1	Homo sapiens	86-91	
28186440-10	2017	The complex crystal structure of Britanin and the BTB domain of Keap1 help clarify the mechanism of Nrf2 induction.	btb	50-53	kelch like ECH associated protein 1	Homo sapiens	64-69	
24896564-4	2014	We report here the first structure of the BTB domain of Keap1, which is thought to contain the key cysteine residue responsible for interaction with electrophiles, as well as structures of the covalent complex with the antagonist CDDO/bardoxolone, and of the constitutively inactive C151W BTB mutant.	btb	289-292	kelch like ECH associated protein 1	Homo sapiens	56-61	
24896564-5	2014	In addition to providing the first structural confirmation of antagonist binding to Keap1 BTB, we also present biochemical evidence that adduction of Cys 151 by CDDO is capable of inhibiting the binding of Cul3 to Keap1, and discuss how this class of compound might exert Nrf2 activation through disruption of the BTB-Cul3 interface.	btb	90-93	kelch like ECH associated protein 1	Homo sapiens	84-89	
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	kelch like ECH associated protein 1	Homo sapiens	80-85	
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	kelch like ECH associated protein 1	Homo sapiens	162-167	
23847398-7	2013	The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures.	btb	45-48	kelch like ECH associated protein 1	Homo sapiens	68-73	
23847398-7	2013	The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures.	btb	118-121	kelch like ECH associated protein 1	Homo sapiens	68-73	
23349464-2	2013	Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single multidomain protein, of which the best known are BTB-BACK-Kelch domain proteins, including KEAP1.	btb	60-63	kelch like ECH associated protein 1	Homo sapiens	254-259