PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9657622-4	1998	The effects of treatment on pressor hormone profiles differed among groups, as spirapril tended to suppress angiotensin II and norepinephrine, whereas isradipine had opposite effects.	spirapril	79-88	angiotensinogen	Homo sapiens	108-122	
1325513-6	1992	RESULTS: Both for the lower and higher doses of spirapril, the time-course of changes of spiraprilat, the active metabolite of spirapril, and ACE activity was similar but the maximal rise in angiotensin I was twofold higher after 2 weeks administration than after the first dose.	spirapril	48-57	angiotensinogen	Homo sapiens	191-204	
1325513-7	1992	Angiotensin II after the first dose of spirapril fell rapidly, with lowest values 2 to 4 h after dosing.	spirapril	39-48	angiotensinogen	Homo sapiens	0-14	
1325513-9	1992	Compared with these first-dose responses the initial maximal degree of angiotensin II suppression after 2 weeks administration of either dose was similar, but during the subsequent hours the degree of angiotensin II suppression tended to be less with the lower and was significantly less with the higher dose of spirapril.	spirapril	312-321	angiotensinogen	Homo sapiens	201-215	
1325513-12	1992	CONCLUSIONS: Repeated ACE inhibitor treatment with once-daily spirapril leads to a partial escape of ACE inhibition, as reflected by a shorter duration of angiotensin II suppression.	spirapril	62-71	angiotensinogen	Homo sapiens	155-169