PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27563403-1 2016 Hint1 has recently emerged to be an important target of interest due to its involvement in the regulation of a broad range of CNS functions including opioid signaling, tolerance, neuropathic pain, and nicotine dependence. Nicotine 201-209 histidine triad nucleotide binding protein 1 Homo sapiens 0-5 20514075-0 2011 Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. Nicotine 91-99 histidine triad nucleotide binding protein 1 Homo sapiens 19-63 20514075-0 2011 Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. Nicotine 91-99 histidine triad nucleotide binding protein 1 Homo sapiens 65-70 20514075-7 2011 These results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking. Nicotine 94-102 histidine triad nucleotide binding protein 1 Homo sapiens 53-58 20514075-7 2011 These results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking. Nicotine 94-102 histidine triad nucleotide binding protein 1 Homo sapiens 125-130