PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31792475-12	2019	The relative expression levels of Wnt pathway proteins including beta-catenin, c-Myc, p-GSK3beta and Ror2 were significantly higher in nicotine group than those in the blank control group and alpha7nAChR inhibition group (P<0.05).	Nicotine	135-143	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	79-84	
33859744-7	2021	In addition, carcinogens, such as nicotine and arecoline, trigger c-MYC-directed NRF2 activation in HNSCC cells.	Nicotine	34-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	66-71	
33662786-3	2021	Since studies have indicated that poorly differentiated tumors are more aggressive and metastasize earlier, leading to poorer prognosis; and cancer stem cells (CSCs) are largely responsible for tumor differentiation state, here we observed that the exposure of nicotine-derived 4-(methylnitrosamino)- 1-(3-pyridyl)- 1-butanone (NNK) promoted cell sphere formation and the expression of the stem cell markers, CD44, OCT4, C-MYC and NANOG in HCT8 and DLD-1 cells.	Nicotine	261-269	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	421-426	
17459420-7	2007	Exposure of SCLC or PNECs to NNK or nicotine increased expression of the alpha7nAChR and caused influx of Ca(2+), activation of PKC, Raf-1, ERK1/2, and c-myc, resulting in the stimulation of cell proliferation.	Nicotine	36-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	152-157	
1772432-0	1991	Transient down-regulation of c-myc protooncogene expression by the alkaloid nicotine in human promyelocytic HL-60 cells.	Nicotine	76-84	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-34	
12494489-4	2003	We found that nicotine and its nitrosated carcinogenic derivative 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) bind to the alpha(7) nAChR in SCLC and PNECs, resulting in the influx of Ca(2+), release of 5-HT, and activation of a mitogenic pathway mediated by protein kinase C (PKC), Raf-1, mitogen activated protein kinase (MAPK) and c-myc.	Nicotine	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	342-347	
1772432-2	1991	We report herein that the nicotine-induced phenotype change is accompanied by the transient reduced expression of mRNA for the protooncogene c-myc.	Nicotine	26-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	141-146	
1772432-3	1991	The suppressive effect of nicotine on c-myc mRNA levels is not reversed by the addition of ADP-ribosyl transferase inhibitor, 3-aminobenzamide.	Nicotine	26-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	38-43