PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33165201-0	2020	Nicotine induces P2X4 receptor, interleukin-1 beta, and brain-derived neurotrophic factor expression in BV2 microglia cells.	Nicotine	0-8	interleukin 1 beta	Mus musculus	32-50	
22803143-1	2012	Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL(50)injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	Nicotine	103-111	interleukin 1 beta	Mus musculus	360-368	
23028093-2	2013	Of 51 genes expressed in the Toll-like receptor (TLR) and RIG-I-like receptor (RLR) pathways, mRNA expression of 15 genes in RAW264.7 cells was attenuated by nicotine, of which mRNA expression of IL-6, TNF-alpha, and IL-1beta was confirmed to be attenuated in peritoneal macrophages.	Nicotine	158-166	interleukin 1 beta	Mus musculus	217-225	
31733211-5	2019	In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production.	Nicotine	31-39	interleukin 1 beta	Mus musculus	176-193	
31733211-5	2019	In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production.	Nicotine	31-39	interleukin 1 beta	Mus musculus	195-203	
28960086-8	2018	In the mothers" lungs, e-cigarette exposure with and without nicotine increased the proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Nicotine	61-69	interleukin 1 beta	Mus musculus	110-118	
28725182-5	2017	In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10.	Nicotine	163-171	interleukin 1 beta	Mus musculus	130-138	
26851533-8	2016	The proinflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-17A were significantly decreased in the infected mice treated with nicotine compared with methyllycaconitine.	Nicotine	130-138	interleukin 1 beta	Mus musculus	41-49	
26925951-8	2016	We thus confirmed this hypothesis by measuring cytokine expression, where we found that nicotine inhibited the production of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-12, while stimulating the secretion of IL-10, an anti-inflammatory cytokine.	Nicotine	88-96	interleukin 1 beta	Mus musculus	166-174	
26507386-8	2015	The mRNA expressions and protein levels of TNF-alpha, IL-1beta, IL-6, and IL-17A were significantly downregulated in dose-dependent manners in the nicotine treatment groups compared to the infected untreated group.	Nicotine	147-155	interleukin 1 beta	Mus musculus	54-62	
23737837-3	2013	Embryos exposed to nicotine (1 mM) exhibited severe morphological anomalies and apoptotic cell death, as well as increased levels of TNF- alpha , IL-1 beta , and caspase 3 mRNAs, and lipid peroxidation.	Nicotine	19-27	interleukin 1 beta	Mus musculus	146-155	
21239632-4	2011	An analysis of the phenotype of isolated brain microvessels after nicotine exposure indicated higher expression of inflammatory mediators, cytokines (IL-1beta, TNF-alpha, and IL-18), chemokines (CCL2 and CX(3)CL1), and adhesion molecules (ICAM-1, VCAM-1, and P-selectins), and this was accompanied by enhanced leukocyte infiltration into brain during ischemia/reperfusion (P < 0.01).	Nicotine	66-74	interleukin 1 beta	Mus musculus	150-158	
21671006-0	2011	The role of IL-1beta in nicotine-induced immunosuppression and neuroimmune communication.	Nicotine	24-32	interleukin 1 beta	Mus musculus	12-20	
21671006-5	2011	To examine the relationship between NT, IL-1beta, and immunosuppression, we hypothesized that NT induces IL-1beta in the brain, and its constant presence produces immunological "tolerance".	Nicotine	94-96	interleukin 1 beta	Mus musculus	40-48	
21671006-5	2011	To examine the relationship between NT, IL-1beta, and immunosuppression, we hypothesized that NT induces IL-1beta in the brain, and its constant presence produces immunological "tolerance".	Nicotine	94-96	interleukin 1 beta	Mus musculus	105-113	
21671006-9	2011	Moreover, the immunosuppressive effects of NT might be at least partly mediated through its effects on the brain IL-1beta.	Nicotine	43-45	interleukin 1 beta	Mus musculus	113-121	
20664191-8	2011	RESULTS: Nicotine pretreatment significantly attenuated the severity of lung injury and inhibited the production of TNF-alpha, IL-1beta and HMGB-1 in mice with ALI.	Nicotine	9-17	interleukin 1 beta	Mus musculus	127-135	
19626424-6	2010	Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha.	Nicotine	96-104	interleukin 1 beta	Mus musculus	188-193	
20223588-10	2010	Perineural injection of nicotine (20nmol), a macrophage suppressor, prevented PSL-induced neuropathic pain and suppressed MIP-1alpha and IL-1beta expressions.	Nicotine	24-32	interleukin 1 beta	Mus musculus	137-145	
16254210-5	2006	We quantified 18 different serum cytokines and found a significant increase of tumor necrosis factor alpha, interleukin 1beta, and keratinocyte-derived chemokine in nicotine-treated mice.	Nicotine	165-173	interleukin 1 beta	Mus musculus	108-125