PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33165201-0 2020 Nicotine induces P2X4 receptor, interleukin-1 beta, and brain-derived neurotrophic factor expression in BV2 microglia cells. Nicotine 0-8 interleukin 1 beta Mus musculus 32-50 22803143-1 2012 Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL(50)injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6. Nicotine 103-111 interleukin 1 beta Mus musculus 360-368 23028093-2 2013 Of 51 genes expressed in the Toll-like receptor (TLR) and RIG-I-like receptor (RLR) pathways, mRNA expression of 15 genes in RAW264.7 cells was attenuated by nicotine, of which mRNA expression of IL-6, TNF-alpha, and IL-1beta was confirmed to be attenuated in peritoneal macrophages. Nicotine 158-166 interleukin 1 beta Mus musculus 217-225 31733211-5 2019 In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production. Nicotine 31-39 interleukin 1 beta Mus musculus 176-193 31733211-5 2019 In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production. Nicotine 31-39 interleukin 1 beta Mus musculus 195-203 28960086-8 2018 In the mothers" lungs, e-cigarette exposure with and without nicotine increased the proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha. Nicotine 61-69 interleukin 1 beta Mus musculus 110-118 28725182-5 2017 In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10. Nicotine 163-171 interleukin 1 beta Mus musculus 130-138 26851533-8 2016 The proinflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-17A were significantly decreased in the infected mice treated with nicotine compared with methyllycaconitine. Nicotine 130-138 interleukin 1 beta Mus musculus 41-49 26925951-8 2016 We thus confirmed this hypothesis by measuring cytokine expression, where we found that nicotine inhibited the production of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-12, while stimulating the secretion of IL-10, an anti-inflammatory cytokine. Nicotine 88-96 interleukin 1 beta Mus musculus 166-174 26507386-8 2015 The mRNA expressions and protein levels of TNF-alpha, IL-1beta, IL-6, and IL-17A were significantly downregulated in dose-dependent manners in the nicotine treatment groups compared to the infected untreated group. Nicotine 147-155 interleukin 1 beta Mus musculus 54-62 23737837-3 2013 Embryos exposed to nicotine (1 mM) exhibited severe morphological anomalies and apoptotic cell death, as well as increased levels of TNF- alpha , IL-1 beta , and caspase 3 mRNAs, and lipid peroxidation. Nicotine 19-27 interleukin 1 beta Mus musculus 146-155 21239632-4 2011 An analysis of the phenotype of isolated brain microvessels after nicotine exposure indicated higher expression of inflammatory mediators, cytokines (IL-1beta, TNF-alpha, and IL-18), chemokines (CCL2 and CX(3)CL1), and adhesion molecules (ICAM-1, VCAM-1, and P-selectins), and this was accompanied by enhanced leukocyte infiltration into brain during ischemia/reperfusion (P < 0.01). Nicotine 66-74 interleukin 1 beta Mus musculus 150-158 21671006-0 2011 The role of IL-1beta in nicotine-induced immunosuppression and neuroimmune communication. Nicotine 24-32 interleukin 1 beta Mus musculus 12-20 21671006-5 2011 To examine the relationship between NT, IL-1beta, and immunosuppression, we hypothesized that NT induces IL-1beta in the brain, and its constant presence produces immunological "tolerance". Nicotine 94-96 interleukin 1 beta Mus musculus 40-48 21671006-5 2011 To examine the relationship between NT, IL-1beta, and immunosuppression, we hypothesized that NT induces IL-1beta in the brain, and its constant presence produces immunological "tolerance". Nicotine 94-96 interleukin 1 beta Mus musculus 105-113 21671006-9 2011 Moreover, the immunosuppressive effects of NT might be at least partly mediated through its effects on the brain IL-1beta. Nicotine 43-45 interleukin 1 beta Mus musculus 113-121 20664191-8 2011 RESULTS: Nicotine pretreatment significantly attenuated the severity of lung injury and inhibited the production of TNF-alpha, IL-1beta and HMGB-1 in mice with ALI. Nicotine 9-17 interleukin 1 beta Mus musculus 127-135 19626424-6 2010 Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha. Nicotine 96-104 interleukin 1 beta Mus musculus 188-193 20223588-10 2010 Perineural injection of nicotine (20nmol), a macrophage suppressor, prevented PSL-induced neuropathic pain and suppressed MIP-1alpha and IL-1beta expressions. Nicotine 24-32 interleukin 1 beta Mus musculus 137-145 16254210-5 2006 We quantified 18 different serum cytokines and found a significant increase of tumor necrosis factor alpha, interleukin 1beta, and keratinocyte-derived chemokine in nicotine-treated mice. Nicotine 165-173 interleukin 1 beta Mus musculus 108-125