PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33379366-1 2020 (1) Background: Nicotine is implicated in the SARS-COV-2 infection through activation of the alpha7-nAChR and over-expression of ACE2. Nicotine 16-24 angiotensin converting enzyme 2 Homo sapiens 129-133 34055688-7 2021 The virus targets the angiotensin converting receptor (ACE receptor), and studies have shown nicotine-based e-cigarettes or vaping cause oxidative stress and resulting in the upregulation of ACE2, which might worsen ARDS in MIS-C. Our mini-review highlights that adolescents using e-cigarette have alterations in their pulmonary defenses against SARS-CoV-2: an upregulation of the ACE2 receptors, the primary target of SARS-CoV-2. Nicotine 93-101 angiotensin converting enzyme 2 Homo sapiens 191-195 34055688-7 2021 The virus targets the angiotensin converting receptor (ACE receptor), and studies have shown nicotine-based e-cigarettes or vaping cause oxidative stress and resulting in the upregulation of ACE2, which might worsen ARDS in MIS-C. Our mini-review highlights that adolescents using e-cigarette have alterations in their pulmonary defenses against SARS-CoV-2: an upregulation of the ACE2 receptors, the primary target of SARS-CoV-2. Nicotine 93-101 angiotensin converting enzyme 2 Homo sapiens 381-385 33850935-0 2021 Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes. Nicotine 0-8 angiotensin converting enzyme 2 Homo sapiens 21-25 33850935-4 2021 We exposed low angiotensin-converting enzyme 2 (ACE2)-expressing human pulmonary adenocarcinoma A549 epithelial cells to nicotine and assessed ACE2 expression at different times. Nicotine 121-129 angiotensin converting enzyme 2 Homo sapiens 15-46 33850935-4 2021 We exposed low angiotensin-converting enzyme 2 (ACE2)-expressing human pulmonary adenocarcinoma A549 epithelial cells to nicotine and assessed ACE2 expression at different times. Nicotine 121-129 angiotensin converting enzyme 2 Homo sapiens 48-52 33850935-6 2021 Nicotine exposure induces rapid and long-lasting increases in gene and protein expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor ACE2, which in turn translates into increased competence for SARS-CoV-2 replication and cytopathic effect. Nicotine 0-8 angiotensin converting enzyme 2 Homo sapiens 167-171 33859566-5 2021 Interestingly, we observed a positive direct correlation between ACE-2 reduction and nicotine delivery. Nicotine 85-93 angiotensin converting enzyme 2 Homo sapiens 65-70 33459225-10 2021 It is important to mention that some natural compounds such as magnolol, resveratrol, rosmarinic acid, tanshinone IIA, and nicotine have also demonstrated the potential to increase the activity or expression of ACE-2, and could therefore aggravate SARS-CoV-2 infection. Nicotine 123-131 angiotensin converting enzyme 2 Homo sapiens 211-216 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 18-26 angiotensin converting enzyme 2 Homo sapiens 163-194 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 18-26 angiotensin converting enzyme 2 Homo sapiens 196-200 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 263-271 angiotensin converting enzyme 2 Homo sapiens 163-194 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 263-271 angiotensin converting enzyme 2 Homo sapiens 196-200 32350104-0 2020 COVID-19 and nicotine as a mediator of ACE-2. Nicotine 13-21 angiotensin converting enzyme 2 Homo sapiens 39-44 33080900-0 2020 In silico Investigation on the Inhibiting Role of Nicotine/Caffeine by Blocking the S Protein of SARS-CoV-2 Versus ACE2 Receptor. Nicotine 50-58 angiotensin converting enzyme 2 Homo sapiens 115-119 33080900-1 2020 In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations. Nicotine 145-153 angiotensin converting enzyme 2 Homo sapiens 55-86 33080900-1 2020 In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations. Nicotine 145-153 angiotensin converting enzyme 2 Homo sapiens 88-92 33080900-2 2020 The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nicotine 70-78 angiotensin converting enzyme 2 Homo sapiens 49-53 33080900-3 2020 We have selected the two most important active sites of ACE2-S protein, i.e., 6LZG and 6VW1, which are critically responsible in the interaction of S protein to the receptor and thus, we investigated their interaction with nicotine and caffeine through MD simulations. Nicotine 223-231 angiotensin converting enzyme 2 Homo sapiens 56-60 33080900-6 2020 Further, we investigated the interaction of ACE2 receptor- S protein with nicotine or caffeine when mixed with candidate or approved antiviral drugs for SARS-CoV-2 therapy. Nicotine 74-82 angiotensin converting enzyme 2 Homo sapiens 44-48 32189428-5 2020 We predict that these individuals are "primed" to be at higher risk because nicotine can directly impact the putative receptor for the virus (ACE2) and lead to deleterious signaling in lung epithelial cells. Nicotine 76-84 angiotensin converting enzyme 2 Homo sapiens 142-146 33033170-7 2020 Further, we have shown possible interactions between nicotine/smoking and ACE2 in the lungs and brain which could aggravate the transmission and pathobiology of COVID-19 resulting in a poor disease outcome. Nicotine 53-61 angiotensin converting enzyme 2 Homo sapiens 74-78 33033170-9 2020 It focuses on the potential negative impact of tobacco and nicotine exposure on the outcomes of this disease by interaction with the ACE2 receptor. Nicotine 59-67 angiotensin converting enzyme 2 Homo sapiens 133-137 33525222-8 2020 As to smoking, nicotine activation of nicotinic receptors leads to enhanced protease activation, apoptosis and inflammatory signaling through the same pathways (Renin-angiotensin system (RAS) and angiotensin-converting enzyme 2 (ACE2)) used by the virus increasing the inflammatory/destructive action of the virus itself. Nicotine 15-23 angiotensin converting enzyme 2 Homo sapiens 196-227 33525222-8 2020 As to smoking, nicotine activation of nicotinic receptors leads to enhanced protease activation, apoptosis and inflammatory signaling through the same pathways (Renin-angiotensin system (RAS) and angiotensin-converting enzyme 2 (ACE2)) used by the virus increasing the inflammatory/destructive action of the virus itself. Nicotine 15-23 angiotensin converting enzyme 2 Homo sapiens 229-233 32552811-6 2020 Sub-chronic e-cig exposure with nicotine increased inflammatory cellular influx of macrophages and T-lymphocytes including increased pro-inflammatory cytokines in BALF and increased SARS-Cov-2 Covid-19 ACE2 receptor, whereas nAChRalpha7 KO mice show reduced inflammatory responses associated with decreased ACE2 receptor. Nicotine 32-40 angiotensin converting enzyme 2 Homo sapiens 202-206 32238438-10 2020 Moreover, we predict that nicotine exposure through various kinds of smoking (cigarettes, electronic cigarettes, or vape) can increase the risk for COVID19 neuroinfection based on known functional interactions between the nicotinic receptor and ACE2. Nicotine 26-34 angiotensin converting enzyme 2 Homo sapiens 245-249 33052306-0 2020 Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2. Nicotine 66-74 angiotensin converting enzyme 2 Homo sapiens 88-92 33815131-5 2021 Nicotine upregulates the expression of ACE2, which can also increase susceptibility to COVID-19, aggravatiing the disease. Nicotine 0-8 angiotensin converting enzyme 2 Homo sapiens 39-43 33802256-8 2021 ACE2 gene expression was significantly increased in cells exposed to the locally bought e-liquid condensate with high nicotine concentration and cigarette smoke extract compared with cell controls. Nicotine 118-126 angiotensin converting enzyme 2 Homo sapiens 0-4 34328284-6 2021 Some authors present that smoking and nicotine reduce the amount of the ACE2 receptors which are used by the novel coronavirus to enter cells, while others claim that ACE2 receptors are upregulated in smokers. Nicotine 38-46 angiotensin converting enzyme 2 Homo sapiens 72-76 35054856-8 2022 Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex. Nicotine 0-8 angiotensin converting enzyme 2 Homo sapiens 85-116 35054856-8 2022 Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex. Nicotine 0-8 angiotensin converting enzyme 2 Homo sapiens 118-123 35054856-8 2022 Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex. Nicotine 0-8 angiotensin converting enzyme 2 Homo sapiens 220-225