PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22209221-0 2012 HBD-1 and hBD-2 expression in HaCaT keratinocytes stimulated with nicotine. Nicotine 66-74 defensin beta 4A Homo sapiens 10-15 22209221-7 2012 RESULTS: Pretreatment with nicotine caused a significant 2.5-fold inhibition of TNF-alpha-stimulated hBD-2 mRNA expression compared to TNF-alpha alone (p = 0.004). Nicotine 27-35 defensin beta 4A Homo sapiens 101-106 22209221-8 2012 Simultaneous treatment with TNF-alpha and nicotine caused a significant 2-fold inhibition of hBD-2 mRNA compared to TNF-alpha alone (p = 0.041). Nicotine 42-50 defensin beta 4A Homo sapiens 93-98 22209221-9 2012 CONCLUSION: The present results suggest that the pre-exposition to nicotine seems to reduce a stimulating effect of TNF-alpha on the gene expression of hBD-2. Nicotine 67-75 defensin beta 4A Homo sapiens 152-157 21267696-0 2010 Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line. Nicotine 0-8 defensin beta 4A Homo sapiens 43-58 21267696-3 2010 The purpose of the present study was to investigate the effect of nicotine on the expression pattern of hBD-2 in keratinocytes. Nicotine 66-74 defensin beta 4A Homo sapiens 104-109 21267696-7 2010 qRT-PCR revealed that the expression level of hBD-2 mRNA was significantly higher at 30 and 80 muM nicotine than the control without nicotine (P < 0.05). Nicotine 99-107 defensin beta 4A Homo sapiens 46-51 21267696-7 2010 qRT-PCR revealed that the expression level of hBD-2 mRNA was significantly higher at 30 and 80 muM nicotine than the control without nicotine (P < 0.05). Nicotine 133-141 defensin beta 4A Homo sapiens 46-51 21267696-9 2010 The p38MAP kinase inhibitor abolished the upregulated expression of hBD-2 by nicotine. Nicotine 77-85 defensin beta 4A Homo sapiens 68-73 21267696-10 2010 Both nAChR inhibitors also abolished the upregulation of hBD-2 by nicotine. Nicotine 66-74 defensin beta 4A Homo sapiens 57-62 21267696-11 2010 The present study demonstrated that nicotine causes upregulated expression of hBD-2 via the p38MAP kinase pathway in keratinocytes. Nicotine 36-44 defensin beta 4A Homo sapiens 78-83 19438974-5 2009 The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay. Nicotine 21-29 defensin beta 4A Homo sapiens 83-98 19438974-5 2009 The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay. Nicotine 21-29 defensin beta 4A Homo sapiens 100-105