PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21267696-0	2010	Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line.	Nicotine	0-8	defensin beta 4A	Homo sapiens	43-58	
21267696-3	2010	The purpose of the present study was to investigate the effect of nicotine on the expression pattern of hBD-2 in keratinocytes.	Nicotine	66-74	defensin beta 4A	Homo sapiens	104-109	
21267696-7	2010	qRT-PCR revealed that the expression level of hBD-2 mRNA was significantly higher at 30 and 80 muM nicotine than the control without nicotine (P < 0.05).	Nicotine	99-107	defensin beta 4A	Homo sapiens	46-51	
21267696-7	2010	qRT-PCR revealed that the expression level of hBD-2 mRNA was significantly higher at 30 and 80 muM nicotine than the control without nicotine (P < 0.05).	Nicotine	133-141	defensin beta 4A	Homo sapiens	46-51	
21267696-9	2010	The p38MAP kinase inhibitor abolished the upregulated expression of hBD-2 by nicotine.	Nicotine	77-85	defensin beta 4A	Homo sapiens	68-73	
21267696-10	2010	Both nAChR inhibitors also abolished the upregulation of hBD-2 by nicotine.	Nicotine	66-74	defensin beta 4A	Homo sapiens	57-62	
21267696-11	2010	The present study demonstrated that nicotine causes upregulated expression of hBD-2 via the p38MAP kinase pathway in keratinocytes.	Nicotine	36-44	defensin beta 4A	Homo sapiens	78-83	
19438974-5	2009	The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay.	Nicotine	21-29	defensin beta 4A	Homo sapiens	83-98	
19438974-5	2009	The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme-linked immunosorbent assay.	Nicotine	21-29	defensin beta 4A	Homo sapiens	100-105	
22209221-0	2012	HBD-1 and hBD-2 expression in HaCaT keratinocytes stimulated with nicotine.	Nicotine	66-74	defensin beta 4A	Homo sapiens	10-15	
22209221-7	2012	RESULTS: Pretreatment with nicotine caused a significant 2.5-fold inhibition of TNF-alpha-stimulated hBD-2 mRNA expression compared to TNF-alpha alone (p = 0.004).	Nicotine	27-35	defensin beta 4A	Homo sapiens	101-106	
22209221-8	2012	Simultaneous treatment with TNF-alpha and nicotine caused a significant 2-fold inhibition of hBD-2 mRNA compared to TNF-alpha alone (p = 0.041).	Nicotine	42-50	defensin beta 4A	Homo sapiens	93-98	
22209221-9	2012	CONCLUSION: The present results suggest that the pre-exposition to nicotine seems to reduce a stimulating effect of TNF-alpha on the gene expression of hBD-2.	Nicotine	67-75	defensin beta 4A	Homo sapiens	152-157