PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11888570-5 2002 The 5-HT(1A) receptors in the DRN play a role in mediating the anxiolytic effects of nicotine and the 5-HT(1A) receptors in the dorsal hippocampus and lateral septum mediate its anxiogenic effects. Nicotine 85-93 5-hydroxytryptamine receptor 1A Homo sapiens 4-11 16341021-4 2006 Prenatal nicotine exposure, which elicits damage to 5HT projections in the cerebral cortex and striatum, produced sex-selective changes in the expression of 5HT(1A) and 5HT2 receptors, along with induction of adenylyl cyclase (AC), leading to sensitization of heterologous inputs operating through this signaling pathway. Nicotine 9-17 5-hydroxytryptamine receptor 1A Homo sapiens 157-163 12838038-1 2003 Alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) and 5-hydroxytryptamine 1A (5-HT1A) receptors have been implicated in the anxiogenic effects of centrally administered nicotine, but the receptors that mediate the anxiogenic effects of systemic nicotine are not known. Nicotine 176-184 5-hydroxytryptamine receptor 1A Homo sapiens 85-91 12838038-1 2003 Alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) and 5-hydroxytryptamine 1A (5-HT1A) receptors have been implicated in the anxiogenic effects of centrally administered nicotine, but the receptors that mediate the anxiogenic effects of systemic nicotine are not known. Nicotine 252-260 5-hydroxytryptamine receptor 1A Homo sapiens 85-91 12838038-3 2003 The anxiogenic effect of 0.1 mg/kg nicotine, given 5 min before the test, was blocked by DHbetaE and WAY 100635, establishing roles for alpha4beta2 nAChRs and 5-HT1A receptors. Nicotine 35-43 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 11888570-6 2002 The increased startle and anxiety during nicotine withdrawal is mediated by 5-HT(1A) and 5-HT(3) receptors. Nicotine 41-49 5-hydroxytryptamine receptor 1A Homo sapiens 76-83 11888570-7 2002 The locomotor stimulant effect of acute nicotine is mediated by 5-HT(1A) receptors and 5-HT(2) receptors may play a role in the expression of a sensitised response after chronic nicotine treatment. Nicotine 40-48 5-hydroxytryptamine receptor 1A Homo sapiens 64-71 11888570-8 2002 Unfortunately, the role of 5-HT(1A) receptors in mediating nicotine seeking has not yet been investigated and would seem an important area for future research. Nicotine 59-67 5-hydroxytryptamine receptor 1A Homo sapiens 27-34 11812255-4 2002 Over the last decade it has been suggested that 5-HT1A receptor antagonists may have therapeutic utility in such diseases as depression, anxiety, drug and nicotine withdrawal as well as schizophrenia. Nicotine 155-163 5-hydroxytryptamine receptor 1A Homo sapiens 48-63 21501256-0 2011 Shifting topographic activation and 5-HT1A receptor-mediated inhibition of dorsal raphe serotonin neurons produced by nicotine exposure and withdrawal. Nicotine 118-126 5-hydroxytryptamine receptor 1A Homo sapiens 36-51 9266775-9 1997 In addition, 5-HT-1A antagonists may be able to relieve some nicotine withdrawal symptoms in man and may represent a novel pharmacotherapy for smoking cessation. Nicotine 61-69 5-hydroxytryptamine receptor 1A Homo sapiens 13-20 10670425-0 2000 Anxiogenic effects of nicotine in the dorsal hippocampus are mediated by 5-HT1A and not by muscarinic M1 receptors. Nicotine 22-30 5-hydroxytryptamine receptor 1A Homo sapiens 73-79 10670425-4 2000 However, the decrease in social interaction after nicotine (50 nmol) was completely reversed by the specific 5-HT1A receptor antagonist, WAY 100635 (0.4 nmol) after co-administration of both drugs into the dorsal hippocampus. Nicotine 50-58 5-hydroxytryptamine receptor 1A Homo sapiens 109-124 10670425-5 2000 Thus, the anxiogenic effect of nicotine in this brain region seems to be mediated by 5-HT1A, but not M1, receptors. Nicotine 31-39 5-hydroxytryptamine receptor 1A Homo sapiens 85-91 1389001-2 1992 In the present study the excitatory action of nicotine was inhibited by treatment with the selective 5-HT re-uptake inhibitor citalopram or the 5-HT1A receptor agonist 8-OH-DPAT. Nicotine 46-54 5-hydroxytryptamine receptor 1A Homo sapiens 144-159 23216389-0 2013 Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. Nicotine 91-99 5-hydroxytryptamine receptor 1A Homo sapiens 53-58 23216389-7 2013 RESULTS: We identified a significant risk region for alcohol and nicotine codependence between IPO11 and HTR1A on chromosome 5q that was reported to be suggestively associated with alcohol dependence previously. Nicotine 65-73 5-hydroxytryptamine receptor 1A Homo sapiens 105-110 23216389-13 2013 CONCLUSIONS: We speculate that this IPO11-HTR1A region might harbor a causal variant for alcohol and nicotine codependence. Nicotine 101-109 5-hydroxytryptamine receptor 1A Homo sapiens 42-47 21501256-7 2011 Previous chronic nicotine exposure did not modify the pattern of activation produced by acute nicotine exposure, but increased 5-HT1A receptor-dependent inhibition of 5-HT cells in the caudal DR. Nicotine 17-25 5-hydroxytryptamine receptor 1A Homo sapiens 127-142 21501256-8 2011 This pattern was nearly reversed during nicotine withdrawal, when there was evidence for caudal activation and mid-level and rostral 5-HT1A receptor-dependent inhibition. Nicotine 40-48 5-hydroxytryptamine receptor 1A Homo sapiens 133-148 21501256-9 2011 These results suggest that the distinct behavioral states produced by nicotine exposure and withdrawal correlate with reciprocal rostral-caudal patterns of activation and 5-HT1A receptor-mediated inhibition of DR 5-HT neurons. Nicotine 70-78 5-hydroxytryptamine receptor 1A Homo sapiens 171-186