PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27938563-5 2016 Results: The results of ELISA showed that compared with the endotoxin+nicotine group of C57 NASH mice, the endotoxin+nicotine group of gene knockout NASH mice had significantly higher levels of IL-6 and TNF-alpha in supernatant (IL-6: 1 599+-65 pg/ml vs 1 465+-45 pg/ml, P < 0.05; TNF-alpha: 1 567+-66 pg/ml vs 1 433+-50 pg/ml, P < 0.05). Nicotine 117-125 interleukin 6 Mus musculus 194-198 27558745-9 2016 Exposure of NHBE cells to nicotine for 5 days increased interleukin (IL)-6 and IL-8 secretion. Nicotine 26-34 interleukin 6 Mus musculus 56-74 27938563-5 2016 Results: The results of ELISA showed that compared with the endotoxin+nicotine group of C57 NASH mice, the endotoxin+nicotine group of gene knockout NASH mice had significantly higher levels of IL-6 and TNF-alpha in supernatant (IL-6: 1 599+-65 pg/ml vs 1 465+-45 pg/ml, P < 0.05; TNF-alpha: 1 567+-66 pg/ml vs 1 433+-50 pg/ml, P < 0.05). Nicotine 117-125 interleukin 6 Mus musculus 229-233 27752155-9 2016 The results of our investigation demonstrated that nicotine could reduce significantly the levels of IL-6, and TNF-alpha in serum (P<0.05). Nicotine 51-59 interleukin 6 Mus musculus 101-105 25616906-7 2015 Nicotine downregulated production of IL-6 and MCP-1 in RA-FLSs induced by TNFalpha in a concentration-dependent manner, and IL-10 levels were not significantly different after nicotine pretreatment. Nicotine 0-8 interleukin 6 Mus musculus 37-41 26397391-5 2015 Investigation of the underlying mechanism showed that nicotine reduced the secretion of the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 6 in vitro and in vivo. Nicotine 54-62 interleukin 6 Mus musculus 151-164 26507386-8 2015 The mRNA expressions and protein levels of TNF-alpha, IL-1beta, IL-6, and IL-17A were significantly downregulated in dose-dependent manners in the nicotine treatment groups compared to the infected untreated group. Nicotine 147-155 interleukin 6 Mus musculus 64-68 26851533-8 2016 The proinflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-17A were significantly decreased in the infected mice treated with nicotine compared with methyllycaconitine. Nicotine 130-138 interleukin 6 Mus musculus 51-55 25616906-11 2015 In conclusion, nicotine has an anti-inflammatory effect on RA by downregulating production of IL-6 and MCP-1 in FLSs, and this is mediated through activation of the JAK2-STAT3 signal pathway. Nicotine 15-23 interleukin 6 Mus musculus 94-98 25258409-8 2014 Furthermore, nicotine inhibited the IL-6 production of CD4 T cells in the DSS-induced inflamed colonic mucosa. Nicotine 13-21 interleukin 6 Mus musculus 36-40 25258409-10 2014 Nicotine markedly inhibited the elevation of TNF-alpha and IL-6 mRNA as well as phosphorylated signal transducer and activator of transcription (Stat) 3 expression in the colons of the tumor model mice. Nicotine 0-8 interleukin 6 Mus musculus 59-63 25258409-12 2014 Furthermore, it is presumed that nicotine downregulates the expression of inflammatory mediators such as IL-6/Stat3 and TNF-alpha, thereby reducing the colonic tumorigenesis associated with chronic colitis. Nicotine 33-41 interleukin 6 Mus musculus 105-109 21597011-8 2011 Oral nicotine administration reduced inflammation within the myocardium, decreased the production of interleukin-6 and tumor necrosis factor-alpha, and downregulated the expression of monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, RANTES, CCR1, CCR2, and CCR5. Nicotine 5-13 interleukin 6 Mus musculus 101-146 24313917-9 2014 Spleen IL-17 level of nicotine-treated mice was lower than that of the control group, and the mRNA expression of pro-inflammatory cytokines (IL-17A and IL-6) in splenocytes were also lower than that of the control group. Nicotine 22-30 interleukin 6 Mus musculus 152-156 24201082-2 2013 Nicotine injection in full-thickness excisional skin wounds minimally affected inflammatory mediators like TNF, IL-6 and IL-12 while it induced a down-regulation in the expression of growth factors like VEGF, PDGF, TGF-beta1 and TGF-beta2, and the anti-inflammatory cytokine IL-10. Nicotine 0-8 interleukin 6 Mus musculus 112-116 25396421-7 2014 Nicotine treatments significantly improved survival rate, attenuated myocardial lesions, and downregulated the expression of TNF-alpha and IL-6. Nicotine 0-8 interleukin 6 Mus musculus 139-143 23028093-2 2013 Of 51 genes expressed in the Toll-like receptor (TLR) and RIG-I-like receptor (RLR) pathways, mRNA expression of 15 genes in RAW264.7 cells was attenuated by nicotine, of which mRNA expression of IL-6, TNF-alpha, and IL-1beta was confirmed to be attenuated in peritoneal macrophages. Nicotine 158-166 interleukin 6 Mus musculus 196-200 23028093-3 2013 Concurrently, nicotine treatment attenuated the release of IL-6 and TNF-alpha from poly(I:C)-stimulated macrophages. Nicotine 14-22 interleukin 6 Mus musculus 59-63 23028093-4 2013 However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process. Nicotine 68-76 interleukin 6 Mus musculus 127-131 22803143-1 2012 Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL(50)injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6. Nicotine 103-111 interleukin 6 Mus musculus 374-378 22093924-3 2012 In muscles and C2C12 myotubes, cholinergic excitation by exposure to nicotine or the organophosphorous pesticide, Paraoxon, induced Tristetraprolin overproduction while reducing pro-inflammatory transcripts such as IL-6, CXCL1 (KC) and CCL2 (MCP-1). Nicotine 69-77 interleukin 6 Mus musculus 215-219 19519907-10 2009 Nicotine also showed a direct anti-inflammatory effect diminishing IL-6 production by stimulated splenocytes in vitro (P < 0.001). Nicotine 0-8 interleukin 6 Mus musculus 67-71 19890701-11 2010 Expression of TNF-alpha and IL-6 decreased in nicotine-pretreated mice compared with model and vagotomy mice; IL-10 levels were not significantly different between the model group and nicotine group. Nicotine 46-54 interleukin 6 Mus musculus 28-32 19626424-6 2010 Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha. Nicotine 96-104 interleukin 6 Mus musculus 195-199 34508846-11 2021 In parallel, we observed increased peripheral levels of IL-6 and IL-10 alongside increased hippocampal levels of NGF but decreased GDNF in mice treated with nicotine compared to controls. Nicotine 157-165 interleukin 6 Mus musculus 56-60 16328020-10 2006 In mouse osteoblasts, nicotine significantly increased IL-6 secretion and estradiol significantly inhibited the nicotine-induced IL-6 release. Nicotine 22-30 interleukin 6 Mus musculus 55-59 16328020-10 2006 In mouse osteoblasts, nicotine significantly increased IL-6 secretion and estradiol significantly inhibited the nicotine-induced IL-6 release. Nicotine 112-120 interleukin 6 Mus musculus 129-133 10727751-7 2000 TNF-alpha and IL-6 production were significantly enhanced by 1 microg/ml of nicotine when cells were pre-incubated with nicotine for 3 h compared to concurrent incubation relative to LPS stimulation. Nicotine 76-84 interleukin 6 Mus musculus 14-18 10727751-7 2000 TNF-alpha and IL-6 production were significantly enhanced by 1 microg/ml of nicotine when cells were pre-incubated with nicotine for 3 h compared to concurrent incubation relative to LPS stimulation. Nicotine 120-128 interleukin 6 Mus musculus 14-18 10727751-9 2000 TNF-alpha production was significantly inhibited by nicotine in young mice, while IL-6 production was significantly inhibited by nicotine in old mice. Nicotine 129-137 interleukin 6 Mus musculus 82-86 10385616-0 1999 Central injection of nicotine increases hepatic and splenic interleukin 6 (IL-6) mRNA expression and plasma IL-6 levels in mice: involvement of the peripheral sympathetic nervous system. Nicotine 21-29 interleukin 6 Mus musculus 60-73 10385616-0 1999 Central injection of nicotine increases hepatic and splenic interleukin 6 (IL-6) mRNA expression and plasma IL-6 levels in mice: involvement of the peripheral sympathetic nervous system. Nicotine 21-29 interleukin 6 Mus musculus 75-79 10385616-0 1999 Central injection of nicotine increases hepatic and splenic interleukin 6 (IL-6) mRNA expression and plasma IL-6 levels in mice: involvement of the peripheral sympathetic nervous system. Nicotine 21-29 interleukin 6 Mus musculus 108-112 10385616-4 1999 injection of nicotine on plasma IL-6 levels were investigated in mice. Nicotine 13-21 interleukin 6 Mus musculus 32-36 10385616-9 1999 Mecamylamine, a nicotinic receptor antagonist, blocked nicotine-induced plasma IL-6 levels. Nicotine 55-63 interleukin 6 Mus musculus 79-83 10385616-10 1999 Depletion of peripheral norepinephrine with 6-hydroxydopamine [100 mg/kg, intraperitoneal (i. p.)] inhibited the nicotine-induced plasma IL-6 levels by 57%, whereas central norepinephrine depletion with 6-hydroxydopamine (50 microgram/mouse, i.c.v.) Nicotine 113-121 interleukin 6 Mus musculus 137-141 10385616-16 1999 ), inhibited nicotine-induced plasma IL-6 levels. Nicotine 13-21 interleukin 6 Mus musculus 37-41 18205805-8 2008 IL-6, IL-10 and IFN-gamma levels in the nicotine-treated mice were higher than those in the control mice. Nicotine 40-48 interleukin 6 Mus musculus 0-4 16332510-5 2006 In the present study, the combined effects of nicotine and bacterial LPS on the expression of IL-6, IL-8, GRO-alpha and MCP-1 in cell lines of human coronary artery endothelial cells (HCAEC) and pulmonary monocytes (THP-1) were examined by quantitative real-time PCR and ELISA. Nicotine 46-54 interleukin 6 Mus musculus 94-98 32638534-9 2020 Nicotine decreased the IL-1beta-induced IL-6 and MMP expression, in a dose-dependent manner, in WT chondrocytes but not in Chrna7-/- chondrocytes. Nicotine 0-8 interleukin 6 Mus musculus 40-44 35479080-9 2022 Nicotine partially prevented the IL1beta-induced expression and production of IL6, MMP3, and RANKL in WT osteoblasts. Nicotine 0-8 interleukin 6 Mus musculus 78-81 35479080-10 2022 The effect for IL6 and MMP was mediated by alpha7nAchR since nicotine had no effect on Chrna7-/- osteoblasts while the RANKL decrease persisted. Nicotine 61-69 interleukin 6 Mus musculus 15-18 30585623-3 2018 The administration of nicotine for 12 weeks increased the area of the atherosclerotic lesion, the number of macrophages infiltrating the plaques, and the circulating levels of inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha, in apolipoprotein E-deficient (ApoE-/- ) mice fed a high-fat diet. Nicotine 22-30 interleukin 6 Mus musculus 208-253 28960086-8 2018 In the mothers" lungs, e-cigarette exposure with and without nicotine increased the proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha. Nicotine 61-69 interleukin 6 Mus musculus 120-124 29161446-7 2018 Exposure to e-cigarette aerosols with and without nicotine caused significant reductions in hippocampal gene expression of Ngfr and Bdnf, as well as in serum levels of cytokines IL-1beta, IL-2, and IL-6. Nicotine 50-58 interleukin 6 Mus musculus 198-202