PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17168719-10 2006 Furthermore apoptosis mechanisms are under the control of the cholinergic system (nicotine antiapoptotic via induction of NF-kappaB complexes and phosphorylation of Bad at S112, curare proapoptotic via G0-G1 arrest p21waf-1-dependent, but p53-independent) [16]. Nicotine 82-90 tumor protein p53 Homo sapiens 239-242 15579018-8 2004 Furthermore apoptosis mechanisms in mesothelioma cells are under the control of the cholinergic system (nicotine antiapoptotic via induction of NF-kappaB complexes and phosphorilation of Bad at Serine(112), curare proapoptotic via G(0)-G(1) arrest p21(waf-1)-dependent, but p53-independent). Nicotine 104-112 tumor protein p53 Homo sapiens 274-277 16011614-6 2005 Nicotine treatment increased p21 expression in immortalized cells (HaCaT, IHOK) and oral cancer cells (HN4, HN12), but decreased pRb and p53 expression in oral cancer cells. Nicotine 0-8 tumor protein p53 Homo sapiens 137-140 34057209-11 2021 Long-term exposure of HGFs to nicotine or CSC significantly suppressed their cellular proliferation and migration and upregulated type I collagen, type III collagen, interleukin (IL)-6, IL-8, p16, p21, and p53 mRNA expression, and IL-6 and IL-8 protein expression. Nicotine 30-38 tumor protein p53 Homo sapiens 206-209 9712657-5 1998 The activation of alpha-Bgt-AChRs by nicotine results in the induction of the tumor suppressor protein p53 and the cdk inhibitor p21. Nicotine 37-45 tumor protein p53 Homo sapiens 103-106 32440821-6 2020 The results showed that the downregulated genes were mainly enriched in synaptic vesicle cycle, nicotine addiction, and GABAergic synapse, whereas the upregulated genes were enriched in the cell cycle, p53 signaling pathway, and cellular senescence. Nicotine 96-104 tumor protein p53 Homo sapiens 202-205 32820905-0 2020 Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway. Nicotine 0-8 tumor protein p53 Homo sapiens 62-65 32820905-0 2020 Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway. Nicotine 0-8 tumor protein p53 Homo sapiens 102-105 32820905-6 2020 Also remarkably, nicotine induced the level of p53 mutation at Ser249 (p53-RS). Nicotine 17-25 tumor protein p53 Homo sapiens 47-50 32820905-6 2020 Also remarkably, nicotine induced the level of p53 mutation at Ser249 (p53-RS). Nicotine 17-25 tumor protein p53 Homo sapiens 71-74 32820905-8 2020 Furthermore, it suggested that CDK6-dependent binding between phosphorylation of p53-RS at Ser249 and PIN1 by nicotine treatment leads to the nucleus translocation, followed by interacting with STAT1 and subsequent activation of STAT1 via the improvement of its stability, which is involved in cellular growth and colony formation after nicotine treatment. Nicotine 110-118 tumor protein p53 Homo sapiens 81-84 32820905-8 2020 Furthermore, it suggested that CDK6-dependent binding between phosphorylation of p53-RS at Ser249 and PIN1 by nicotine treatment leads to the nucleus translocation, followed by interacting with STAT1 and subsequent activation of STAT1 via the improvement of its stability, which is involved in cellular growth and colony formation after nicotine treatment. Nicotine 337-345 tumor protein p53 Homo sapiens 81-84 32820905-9 2020 Simply put, these findings indicated that nicotine induces mutant p53 gain-of function (GOF), activating CDK6-p53-RS-PIN1-STAT1 signaling pathway and promoting cell proliferation, which could contribute to HCC for smokers. Nicotine 42-50 tumor protein p53 Homo sapiens 66-69 32820905-9 2020 Simply put, these findings indicated that nicotine induces mutant p53 gain-of function (GOF), activating CDK6-p53-RS-PIN1-STAT1 signaling pathway and promoting cell proliferation, which could contribute to HCC for smokers. Nicotine 42-50 tumor protein p53 Homo sapiens 110-113 32649943-4 2020 Nicotine inhibited the proliferation of SKOV3 and TOV112D OC cells, which have TP53 mutation and wild-type KRAS, but did not inhibit the proliferation of TOV21G or HEY OC cells, which have KRAS mutation and wild-type TP53. Nicotine 0-8 tumor protein p53 Homo sapiens 79-83 30272249-0 2019 Nicotine Promotes Human Papillomavirus (HPV)-Immortalized Cervical Epithelial Cells (H8) Proliferation by Activating RPS27a-Mdm2-P53 Pathway In Vitro. Nicotine 0-8 tumor protein p53 Homo sapiens 129-132 32001831-8 2020 Furthermore, prolonged nicotine exposure interferes with p53 function triggered by sodium arsenite. Nicotine 23-31 tumor protein p53 Homo sapiens 57-60 32001831-10 2020 CONCLUSION: The data suggest that nicotine treatment, by perturbing intracellular redox state and altering p53 function, can create a pro-tumorigenic environment in lung epithelium. Nicotine 34-42 tumor protein p53 Homo sapiens 107-110 30912145-6 2019 Then, we found that the pretreatment with nicotine and PNU-282987 showed the neuroprotective antiapoptotic effects via activating the alpha7-nAChRs/MAPK/p53 axis. Nicotine 42-50 tumor protein p53 Homo sapiens 153-156 30272249-5 2019 Moreover, nicotine decreased the level of P53, resulted from a shortened P53 half-life. Nicotine 10-18 tumor protein p53 Homo sapiens 42-45 30272249-5 2019 Moreover, nicotine decreased the level of P53, resulted from a shortened P53 half-life. Nicotine 10-18 tumor protein p53 Homo sapiens 73-76 30272249-7 2019 It suggested that reduction in stabilization of P53 induced by nicotine may be negative regulator for P53/P21 signaling pathway that acts to prevent the growth of cells. Nicotine 63-71 tumor protein p53 Homo sapiens 48-51 30272249-7 2019 It suggested that reduction in stabilization of P53 induced by nicotine may be negative regulator for P53/P21 signaling pathway that acts to prevent the growth of cells. Nicotine 63-71 tumor protein p53 Homo sapiens 102-105 30272249-8 2019 In addition, reduction of RPS27a expression in nicotine treatment H8 cells up-regulated phosphorylation of Mdm2 at serine residue 166, followed by facilitating Mdm2-mediated ubiquitination of P53. Nicotine 47-55 tumor protein p53 Homo sapiens 192-195 30272249-9 2019 Simply put, these findings suggest that nicotine promotes H8 cell lines proliferation by activating RPS27a-Mdm2-P53 pathway in vitro. Nicotine 40-48 tumor protein p53 Homo sapiens 112-115 22382680-8 2012 Western blot analysis confirmed that p53 proteins were phosphorylated by nicotine. Nicotine 73-81 tumor protein p53 Homo sapiens 37-40 27769050-7 2016 A series of biochemical experiments using nicotine-treated cells suggested that the dephosphorylation of p53 (Ser-20) and BAX (Ser-184) by PPM1F is a critical posttranslational modification, as observed in breast cancer patients who were heavy smokers. Nicotine 42-50 tumor protein p53 Homo sapiens 105-108 30257366-0 2018 Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Nicotine 49-57 tumor protein p53 Homo sapiens 85-88 22382680-9 2012 Under various doses of nicotine, a decrease in the anti-apoptotic protein Bcl-2, but an increase in p53 and cleaved caspase-3 protein levels, was detected in a dose-dependent manner. Nicotine 23-31 tumor protein p53 Homo sapiens 100-103 20491334-4 2010 Comparative analysis of frequency of p53 occurrence in serum in three studied group has been done with respect to nicotine addiction in COPD and NSCLC groups. Nicotine 114-122 tumor protein p53 Homo sapiens 37-40 20727180-0 2010 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Nicotine 0-8 tumor protein p53 Homo sapiens 79-82 20727180-3 2010 We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. Nicotine 44-52 tumor protein p53 Homo sapiens 103-106 20727180-3 2010 We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. Nicotine 44-52 tumor protein p53 Homo sapiens 121-124 20727180-3 2010 We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. Nicotine 44-52 tumor protein p53 Homo sapiens 121-124 20727180-3 2010 We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. Nicotine 199-207 tumor protein p53 Homo sapiens 103-106 20727180-3 2010 We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. Nicotine 199-207 tumor protein p53 Homo sapiens 121-124 20727180-3 2010 We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. Nicotine 199-207 tumor protein p53 Homo sapiens 121-124 20727180-7 2010 The hypothesis was confirmed when lower concentrations of nicotine induced NF-kappaB in two more lung cancer cells, Hop-92 and NCI-H522 with mutant p53 status. Nicotine 58-66 tumor protein p53 Homo sapiens 148-151 20727180-8 2010 Silencing of p53 in A549 using siRNA made the cells susceptible to nicotine-induced NF-kappaB nuclear translocation as in A549 DN-p53 cells. Nicotine 67-75 tumor protein p53 Homo sapiens 13-16 20727180-8 2010 Silencing of p53 in A549 using siRNA made the cells susceptible to nicotine-induced NF-kappaB nuclear translocation as in A549 DN-p53 cells. Nicotine 67-75 tumor protein p53 Homo sapiens 130-133 20727180-9 2010 CONCLUSIONS: The present study reveals a detrimental role of nicotine especially in lung cancer patients with impaired p53 status and identifies curcumin as a potential chemopreventive. Nicotine 61-69 tumor protein p53 Homo sapiens 119-122 20339300-8 2010 Real-time PCR indicated that the expression of Bcl-2, Pax3, Bmp4 and Slug was down-regulated in the nicotine group, while the expression of P53, Bax and Msx1 was up-regulated. Nicotine 100-108 tumor protein p53 Homo sapiens 140-143 19139119-7 2009 Rosiglitazone was also found to stimulate p53, a tumor suppressor known to mediate some of the effects of nicotine. Nicotine 106-114 tumor protein p53 Homo sapiens 42-45