PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33813843-5 2021 Reduction of renal 11beta-HSD2 expression by nicotine was correlated with the suppression of C/EBPbeta (CCAAT/enhancer-binding protein-beta) and activation of Akt protein kinase phosphorylation (pThr308Akt/PKB) within the kidney. Nicotine 45-53 thymoma viral proto-oncogene 1 Mus musculus 159-162 34648060-8 2021 The PI3K-Akt signaling was involved in nicotine-CPP via GPR55 activation. Nicotine 39-47 thymoma viral proto-oncogene 1 Mus musculus 9-12 34440849-11 2021 Mechanistically, we observed that nicotine regulated YAP nuclear translocation and its interaction with TEAD through alpha7-nAChR-Akt signaling, subsequently resulting in increased TEAD occupancy on the HSPA5 promoter and elevated promoter activity. Nicotine 34-42 thymoma viral proto-oncogene 1 Mus musculus 130-133 34586895-0 2021 Platelet-Derived Biomaterials Inhibit Nicotine-Induced Intervertebral Disc Degeneration Through Regulating IGF-1/AKT/IRS-1 Signaling Axis. Nicotine 38-46 thymoma viral proto-oncogene 1 Mus musculus 113-116 34586895-10 2021 Conclusively, the PDB impart reparative and tissue regenerative processes by inhibiting nicotine-initiated IVD degeneration, through regulating IGF-1/AKT/IRS-1 signaling axis. Nicotine 88-96 thymoma viral proto-oncogene 1 Mus musculus 150-153 35533447-10 2022 Moreover, inhibiting PI3K-AKT by LY294002 abrogated nicotine-mediated beta-catenin level increase and thymopoiesis abnormalities, and an alpha7 nAChR antagonist (alpha-btx) also reversed nicotine-induced PI3K-AKT activation. Nicotine 52-60 thymoma viral proto-oncogene 1 Mus musculus 209-212 35533447-10 2022 Moreover, inhibiting PI3K-AKT by LY294002 abrogated nicotine-mediated beta-catenin level increase and thymopoiesis abnormalities, and an alpha7 nAChR antagonist (alpha-btx) also reversed nicotine-induced PI3K-AKT activation. Nicotine 187-195 thymoma viral proto-oncogene 1 Mus musculus 26-29 33813843-5 2021 Reduction of renal 11beta-HSD2 expression by nicotine was correlated with the suppression of C/EBPbeta (CCAAT/enhancer-binding protein-beta) and activation of Akt protein kinase phosphorylation (pThr308Akt/PKB) within the kidney. Nicotine 45-53 thymoma viral proto-oncogene 1 Mus musculus 206-209 33813843-7 2021 Treatment with the MR antagonist spironolactone significantly decreased the elevated mean systolic blood pressure and corrected ENaC along with inhibition of pThr308Akt/PKB within the kidney in nicotine-treated mice. Nicotine 194-202 thymoma viral proto-oncogene 1 Mus musculus 165-172 33813843-8 2021 Suppression of Akt/PKB activation by spironolactone was accompanied by upregulation of renal C/EBPbeta and amelioration of nicotine-mediated reduction of 11beta-HSD2. Nicotine 123-131 thymoma viral proto-oncogene 1 Mus musculus 15-18 33813843-8 2021 Suppression of Akt/PKB activation by spironolactone was accompanied by upregulation of renal C/EBPbeta and amelioration of nicotine-mediated reduction of 11beta-HSD2. Nicotine 123-131 thymoma viral proto-oncogene 1 Mus musculus 19-22 33813843-9 2021 Addition of nicotine to mouse renal cortical collecting duct M1 cells downregulated 11beta-HSD2 and stimulated MR expression, and these effects are likely mediated by activation of Akt coupled inhibition of C/EBPbeta. Nicotine 12-20 thymoma viral proto-oncogene 1 Mus musculus 181-184 33894105-0 2021 Maternal nicotine exposure aggravates metabolic associated fatty liver disease via PI3K/Akt signaling in adult offspring mice. Nicotine 9-17 thymoma viral proto-oncogene 1 Mus musculus 88-91 32815115-5 2020 Furthermore, chronic exposure to nicotine enhanced the PI3K/Akt and ERK/CREB pathways and increased BDNF expression in the DG of CaMKIV null mice. Nicotine 33-41 thymoma viral proto-oncogene 1 Mus musculus 60-63 32815115-8 2020 Taken together, we demonstrated that chronic exposure to nicotine rescues depressive-like behavior via alpha7-type nAChR through the activation of both PI3K/Akt and ERK/CREB pathways in CaMKIV null mice. Nicotine 57-65 thymoma viral proto-oncogene 1 Mus musculus 157-160 31783125-10 2020 Nicotine treatment also induced MEC apoptosis concurrently with inactivation of Akt. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 80-83 32669976-9 2020 After specific knockdown of alpha7-nAChRs and inhibition of the PI3/AKT signal, the effect of nicotine on SNCG expression was attenuated. Nicotine 94-102 thymoma viral proto-oncogene 1 Mus musculus 68-71 32669976-12 2020 Conclusion: Nicotine upregulated SNCG expression by activating the alpha7-nAChRs/PI3/AKT signaling that are participated in nicotine-induced oral cancer malignancy. Nicotine 12-20 thymoma viral proto-oncogene 1 Mus musculus 85-88 32669976-12 2020 Conclusion: Nicotine upregulated SNCG expression by activating the alpha7-nAChRs/PI3/AKT signaling that are participated in nicotine-induced oral cancer malignancy. Nicotine 124-132 thymoma viral proto-oncogene 1 Mus musculus 85-88 32757664-0 2020 Amelioration of Nicotine-Induced Osteoarthritis by Platelet-Derived Biomaterials Through Modulating IGF-1/AKT/IRS-1 Signaling Axis. Nicotine 16-24 thymoma viral proto-oncogene 1 Mus musculus 106-109 31941383-8 2020 Finally, at the molecular level, it was found that Akt (protein kinase B) and ERK (extracellular signal-regulated kinases) phosphorylation are enhanced in the WPS and in nicotine-treated platelets. Nicotine 170-178 thymoma viral proto-oncogene 1 Mus musculus 51-54 32757664-11 2020 Taken together, the PDB exerts regenerative and reparative activities in nicotine-mediated initiation and progression of OA, through modulating IGF-1/AKT/IRS-1 signaling axis. Nicotine 73-81 thymoma viral proto-oncogene 1 Mus musculus 150-153 29339018-12 2018 Consequently, chronic nicotine played a role of neuroprotection in either CUS mice or corticosterone cells associating with the enhancement of the autophagy signaling, which was involved in activating the PI3K/Akt/mTOR signaling. Nicotine 22-30 thymoma viral proto-oncogene 1 Mus musculus 210-213 31612866-7 2019 nAChRalpha1 knockdown significantly decreases the nicotine-induced upregulation of p-STAT3, p-Akt and p-mTOR in vitro, while nAChRalpha1 overexpression has the opposite effects. Nicotine 50-58 thymoma viral proto-oncogene 1 Mus musculus 94-97 31612866-9 2019 Moreover, there is a direct interaction between STAT3 and nAChRalpha1 that modulates STAT3 nuclear translocation and its binding to the Akt promoter region upon nicotine exposure. Nicotine 161-169 thymoma viral proto-oncogene 1 Mus musculus 136-139 31612866-10 2019 Taken together, STAT3 and nAChRalpha1 blockade attenuates nicotine-induced atherosclerosis by reducing the migration and proliferation of vascular smooth muscle cells and inflammation in macrophages via the Akt/mTOR pathway. Nicotine 58-66 thymoma viral proto-oncogene 1 Mus musculus 207-210 31152077-9 2019 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine 13-21 thymoma viral proto-oncogene 1 Mus musculus 50-53 31152077-9 2019 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine 13-21 thymoma viral proto-oncogene 1 Mus musculus 282-285 31152077-9 2019 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine 177-185 thymoma viral proto-oncogene 1 Mus musculus 50-53 31152077-9 2019 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine 177-185 thymoma viral proto-oncogene 1 Mus musculus 282-285 31005665-10 2019 Our results showed that nicotine significantly reduced hyperalgesia in mice that received acute or repeated rapamycin injections, and reversed the effects of rapamycin on the phosphorylation of S6K, 4E-BP1, insulin receptor substrate-1 (IRS-1) at Ser636/639, AKT at Ser473, and ERK at Thr202/Tyr204. Nicotine 24-32 thymoma viral proto-oncogene 1 Mus musculus 259-262 30833077-8 2019 Nicotine also activated the PI3K/Akt signaling pathway, while blocking PI3K with the inhibitor LY294002 abrogated the effects of nicotine on the differentiation of C2C12 cells. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 33-36 30833077-11 2019 Taken together, our data suggested that nicotine promoted the differentiation of C2C12 cells through activation of the PI3K/Akt pathway and rescued the impaired skeletal muscle regeneration in obese mice. Nicotine 40-48 thymoma viral proto-oncogene 1 Mus musculus 124-127 29615536-3 2018 Moreover, the ovaries of pups injected with nicotine showed increased level of cell oxidative stress and autophagic markers (upregulation of AMPKalpha-1, increased ratio LC3-II/LC3-I, downregulation of AKT and mTOR). Nicotine 44-52 thymoma viral proto-oncogene 1 Mus musculus 202-205 23543412-11 2013 These findings indicate that nicotine-induced structural plasticity at mesencephalic dopaminergic neurons involves alpha4beta2 nAChRs together with dopamine D3R-mediated recruitment of ERK/Akt-mTORC1 signaling. Nicotine 29-37 thymoma viral proto-oncogene 1 Mus musculus 189-192 24298024-9 2014 Nicotine enhanced PI3K/Akt activation and reduced PU.1 activity and TLR4 expression. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 23-26 27424921-10 2016 Immunohistochemistry showed enhanced expression levels of aPKC and phosphorylated Akt in nodules from nicotine-treated mice. Nicotine 102-110 thymoma viral proto-oncogene 1 Mus musculus 82-85 27312847-6 2016 Nicotine-induced NET formation is mediated via nicotine acetylcholine receptors, depends on Akt and PAD4 activation, but is Nox2-independent, as demonstrated by pharmacological inhibition of Nox2 and by use of Nox2-deficient mouse neutrophils. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 92-95 25051446-13 2014 Chronic nicotine treatment enhanced PI-3-kinase activities and increased Akt and glycogen synthase kinase (GSK)-3beta phosphorylation in an nAChR-dependent manner coupled with decreased cAMP response element-binding protein (CREB) phosphorylation. Nicotine 8-16 thymoma viral proto-oncogene 1 Mus musculus 73-76 23543412-0 2013 Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 118-121 12566374-8 2003 The effects of nicotine were mediated in part by the phosphorylation of the PI3 kinase downstream target Akt and the mitogen-activated kinases ERK and p38 MAPK. Nicotine 15-23 thymoma viral proto-oncogene 1 Mus musculus 105-108 22546501-0 2012 Nicotine stimulated bone marrow-derived dendritic cells could augment HBV specific CTL priming by activating PI3K-Akt pathway. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 114-117 22546501-7 2012 The results showed that: first, the maximal activation of PI3K and Akt was reached at 30 and 60-120 min respectively after nicotine stimulation. Nicotine 123-131 thymoma viral proto-oncogene 1 Mus musculus 67-70 22546501-8 2012 Nicotine up-regulated the expression of alpha7 nAChR by activating PI3K-Akt pathway in murine DCs; secondly, nicotine stimulation could enhance DCs" ability of HBV-specific T cell proliferation and IL-12 secretion; thirdly, adoptive transfer of nicotine stimulated DCs could induce HBV specific CTL priming in vivo and those CTL had cytolytic activities; fourthly, nicotine had equal efficiencies to 2 ng/ml IFN-gamma in DCs-mediated T cell proliferation. Nicotine 0-8 thymoma viral proto-oncogene 1 Mus musculus 72-75 22526143-7 2012 RESULTS: Nicotine treatment transiently induced translation of GluR2 mRNA and Akt phosphorylation with a concomitant increase of YB-1/HSP60 interaction. Nicotine 9-17 thymoma viral proto-oncogene 1 Mus musculus 78-81 23535606-11 2013 The nuclear translocation of NF-E2-related factor 2 and phosphorylation of both phosphatidyl inositol 3-kinase and Akt increased; nicotine also augmented these increases. Nicotine 130-138 thymoma viral proto-oncogene 1 Mus musculus 115-118 23275008-7 2013 Moreover, BCX supplementation restored the nicotine-suppressed expression of lung SIRT1, p53, and RAR-beta to that of the control group, increased survival probability, and decreased the levels of lung il-6 mRNA and phosphorylation of AKT. Nicotine 43-51 thymoma viral proto-oncogene 1 Mus musculus 235-238 23146955-4 2013 RESULTS: Exposure in vitro to nicotine for 7 days inhibited the gemcitabine-induced reduction in viable cells, gemcitabine-induced apoptosis as indicated by reduced expression of cleaved caspase-3 while inducing the phosphorylation of signalling proteins extracellular signal-regulated kinase (ERK), v-akt thymoma viral oncogene homolog (protein kinase B, AKT) and Src. Nicotine 30-38 thymoma viral proto-oncogene 1 Mus musculus 302-305 23146955-4 2013 RESULTS: Exposure in vitro to nicotine for 7 days inhibited the gemcitabine-induced reduction in viable cells, gemcitabine-induced apoptosis as indicated by reduced expression of cleaved caspase-3 while inducing the phosphorylation of signalling proteins extracellular signal-regulated kinase (ERK), v-akt thymoma viral oncogene homolog (protein kinase B, AKT) and Src. Nicotine 30-38 thymoma viral proto-oncogene 1 Mus musculus 356-359 21083424-4 2011 Here we show that HO-1-inducible effect by nicotine was mediated through sequential event-Ca(2+) influx, classical protein kinase C activation, and reactive oxygen species production-which activates phosphoinositol-3-kinase/Akt/Nrf-2 pathway. Nicotine 43-51 thymoma viral proto-oncogene 1 Mus musculus 224-227 18803299-8 2009 We found that DA neuroprotective effects of nicotine were inhibited by dihydro-beta-erythroidine (DHbetaE), alpha-bungarotoxin (alphaBuTx), and/or PI3K-Akt/PKB (protein serine/threonine kinase B) inhibitors, demonstrating that rotenone-toxicity on DA neurons are inhibited via activation of alpha4beta2 or alpha7 nAChRs-PI3K-Akt/PKB pathway or pathways. Nicotine 44-52 thymoma viral proto-oncogene 1 Mus musculus 147-159 18803299-8 2009 We found that DA neuroprotective effects of nicotine were inhibited by dihydro-beta-erythroidine (DHbetaE), alpha-bungarotoxin (alphaBuTx), and/or PI3K-Akt/PKB (protein serine/threonine kinase B) inhibitors, demonstrating that rotenone-toxicity on DA neurons are inhibited via activation of alpha4beta2 or alpha7 nAChRs-PI3K-Akt/PKB pathway or pathways. Nicotine 44-52 thymoma viral proto-oncogene 1 Mus musculus 156-159 12962196-7 2003 Activated Akt-Ser473 was greater in control MEE than in nicotine treated tissues; while there was no difference in activated Smad2 between groups. Nicotine 56-64 thymoma viral proto-oncogene 1 Mus musculus 10-13 12511591-4 2003 Activation of Akt by nicotine or NNK occurred within minutes at concentrations achievable by smokers and depended upon alpha(3)-/alpha(4)-containing or alpha(7)-containing nicotinic acetylcholine receptors, respectively. Nicotine 21-29 thymoma viral proto-oncogene 1 Mus musculus 14-17 12511591-8 2003 Redundant Akt activation by nicotine and NNK could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis. Nicotine 28-36 thymoma viral proto-oncogene 1 Mus musculus 10-13 12511591-0 2003 Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. Nicotine 24-32 thymoma viral proto-oncogene 1 Mus musculus 6-9