PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21494800-8	2012	Nicotine upregulated OPN, IL-6, and MCP-1 expressions, and this effect attenuated after PDTC pretreatment.	Nicotine	0-8	C-C motif chemokine ligand 2	Homo sapiens	36-41	
31631328-6	2020	Moreover, it was observed that nicotine decreases the production of interleukin (IL)-6 and C-C chemokine ligand (CCL)5 during Mtb infection in epithelial cells (EpCs), whereas in macrophages derived from human monocytes (MDMs) there is a decrease in IL-8, IL-6, tumor necrosis factor (TNF)-alpha, IL-10, CCL2, C-X-C chemokine ligand (CXCL)9 and CXCL10 only during infection with Mtb.	Nicotine	31-39	C-C motif chemokine ligand 2	Homo sapiens	304-308	
30030777-7	2019	MCP-1 secretion was suppressed by nicotine, alone and together with Pg LPS, while 4-NQO activated its secretion.	Nicotine	34-42	C-C motif chemokine ligand 2	Homo sapiens	0-5	
23279317-4	2013	RESULTS: Exposure to nicotine caused significant down-regulation in the expression of IL-10 (P = 0.046), growth-regulated oncogene (GRO)alpha (P = 0.036), MCP-1 (P = 0.046), and GMCSF (P = 0.004) compared with the control untreated HUVECs.	Nicotine	21-29	C-C motif chemokine ligand 2	Homo sapiens	155-160	
19741199-5	2009	Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway.	Nicotine	149-157	C-C motif chemokine ligand 2	Homo sapiens	205-239	
19741199-5	2009	Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway.	Nicotine	149-157	C-C motif chemokine ligand 2	Homo sapiens	241-246