PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16019605-9	2005	In vivo, uveal release of t-PA increased more than three-fold within one minute following superior cervical sympathetic ganglion electrical stimulation, and after phenylephrine, or nicotine infusions of the anterior chamber.	Nicotine	181-189	chromosome 20 open reading frame 181	Homo sapiens	26-30	
17944865-1	2007	We have previously demonstrated that tissue plasminogen activator (tPA) plays an important role through the conversion of plasminogen to plasmin in the release of dopamine in the nucleus accumbens (NAc) evoked by depolarization or the systemic administration of drugs of abuse such as morphine and nicotine.	Nicotine	298-306	chromosome 20 open reading frame 181	Homo sapiens	37-65	
17944865-1	2007	We have previously demonstrated that tissue plasminogen activator (tPA) plays an important role through the conversion of plasminogen to plasmin in the release of dopamine in the nucleus accumbens (NAc) evoked by depolarization or the systemic administration of drugs of abuse such as morphine and nicotine.	Nicotine	298-306	chromosome 20 open reading frame 181	Homo sapiens	67-70	
11684081-0	2001	Short-term effects of transdermal nicotine on acute tissue plasminogen activator release in vivo in man.	Nicotine	34-42	chromosome 20 open reading frame 181	Homo sapiens	52-80	
11684081-8	2001	Compared with placebo, nicotine administration increased the substance-P-induced release of t-PA antigen and activity (P<0.05 for both) without an effect on endothelium-dependent or -independent vasodilatation.	Nicotine	23-31	chromosome 20 open reading frame 181	Homo sapiens	92-96	
11684081-9	2001	CONCLUSIONS: Short-term transdermal nicotine treatment does not affect endothelium-dependent vasomotion but does increase substance-P-induced t-PA release in vivo in man.	Nicotine	36-44	chromosome 20 open reading frame 181	Homo sapiens	142-146	
11684081-11	2001	The long-term effects of nicotine exposure, including the potential to cause depletion of endothelial t-PA stores, now needs to be assessed.	Nicotine	25-33	chromosome 20 open reading frame 181	Homo sapiens	102-106