PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10525113-4 1999 Multiple injections of nicotine bitartrate (5 mg/kg) elevated mRNA levels for the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase, and of preproneuropeptide Y in rat adrenal medulla more than did 1 mg/kg of nicotine bitartrate. Nicotine 23-42 dopamine beta-hydroxylase Rattus norvegicus 145-170 20827341-6 2010 Nicotine as a ligand of the nicotinic acetylcholine receptor (nAChR) in adrenal medulla stimulates catecholamine secretion and activates TH and DBH gene expression. Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 144-147 20827341-7 2010 Nicotine treatment increased mRNA levels of TH and DBH by 3.3- and 3.1-fold in PC12 cells. Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 51-54 20827341-8 2010 The ginseng total saponin exhibited a significant reversal in the nicotine-induced increase of TH and DBH mRNA expression, decreasing the mRNA levels of TH and DBH by 57.2% and 48.9%, respectively in PC12 cells. Nicotine 66-74 dopamine beta-hydroxylase Rattus norvegicus 102-105 20827341-8 2010 The ginseng total saponin exhibited a significant reversal in the nicotine-induced increase of TH and DBH mRNA expression, decreasing the mRNA levels of TH and DBH by 57.2% and 48.9%, respectively in PC12 cells. Nicotine 66-74 dopamine beta-hydroxylase Rattus norvegicus 160-163 16324736-4 2005 In adrenal medulla (AM), response of dopamine beta-hydroxylase (DBH), but not tyrosine hydroxylase (TH) mRNA, to both stressors was attenuated in nicotine-infused rats. Nicotine 146-154 dopamine beta-hydroxylase Rattus norvegicus 37-62 16324736-4 2005 In adrenal medulla (AM), response of dopamine beta-hydroxylase (DBH), but not tyrosine hydroxylase (TH) mRNA, to both stressors was attenuated in nicotine-infused rats. Nicotine 146-154 dopamine beta-hydroxylase Rattus norvegicus 64-67 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 218-243 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 245-248 11032889-7 2000 These agonists were more effective than nicotine alone in increasing TH and DBH gene expression and significantly elevated [Ca(2+)](i) for up to 6 h. The increase in [Ca(2+)](i) or the elevation in TH mRNA by 3-CA was completely inhibited by alphaBTX. Nicotine 40-48 dopamine beta-hydroxylase Rattus norvegicus 76-79 10525113-4 1999 Multiple injections of nicotine bitartrate (5 mg/kg) elevated mRNA levels for the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase, and of preproneuropeptide Y in rat adrenal medulla more than did 1 mg/kg of nicotine bitartrate. Nicotine 23-42 dopamine beta-hydroxylase Rattus norvegicus 172-175 10525113-4 1999 Multiple injections of nicotine bitartrate (5 mg/kg) elevated mRNA levels for the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase, and of preproneuropeptide Y in rat adrenal medulla more than did 1 mg/kg of nicotine bitartrate. Nicotine 298-317 dopamine beta-hydroxylase Rattus norvegicus 172-175 10525113-8 1999 In the central nervous system, the chronic infusion of nicotine prevented the induction of TH mRNA by repeated IMO stress in the ventral tegmental area (but not in substantia nigra) and of DBH mRNA by single IMO in the locus ceruleus. Nicotine 55-63 dopamine beta-hydroxylase Rattus norvegicus 189-192 10466743-4 1999 PAMP (> or =1 microM) significantly inhibited the nicotine-induced increases of TH- and DBH mRNA expression in a concentration-dependent manner. Nicotine 53-61 dopamine beta-hydroxylase Rattus norvegicus 91-94 23301-2 1978 Nicotine 3 mg/kg/day for 14 days, increased tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in hypothalamus and adrenal medulla but did change striatum TH. Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 74-99 6158829-0 1980 Effect of chronically administered nicotine on axonal transport of dopamine-beta-hydroxylase in peripheral adrenergic neurons and on blood pressure and heart rate in the rat. Nicotine 35-43 dopamine beta-hydroxylase Rattus norvegicus 67-92 7494448-8 1995 These data indicate that activation of several transcription factors and increased expression of TH, DBH, and NPY is dependent on the mode of nicotine administration. Nicotine 142-150 dopamine beta-hydroxylase Rattus norvegicus 101-104 7901211-2 1993 Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 195-198 7901211-3 1993 We investigated the effect of long term treatment with nicotine on TH and DBH gene expression in rat PC12 pheochromocytoma cells. Nicotine 55-63 dopamine beta-hydroxylase Rattus norvegicus 74-77 7901211-4 1993 Nicotine treatment for 1-2 days increased both the TH and DBH mRNA levels. Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 58-61 23301-2 1978 Nicotine 3 mg/kg/day for 14 days, increased tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in hypothalamus and adrenal medulla but did change striatum TH. Nicotine 0-8 dopamine beta-hydroxylase Rattus norvegicus 101-104 3249-5 1976 5 Dopamine beta-hydroxylase levels increased similarly in both sides during treatment with nicotine (10 mg/kg). Nicotine 91-99 dopamine beta-hydroxylase Rattus norvegicus 2-27 7752-5 1976 Carbamylcholine, acetylcholine and nicotine at concentrations of 10(-4) M elicited a selective induction of TH and DBH both in intact and decentralized ganglia via nicotinic receptor stimulation. Nicotine 35-43 dopamine beta-hydroxylase Rattus norvegicus 115-118