PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23475432-9 2013 The toxic effects of MAO significantly attenuated with nicotine pre-exposure. Nicotine 55-63 monoamine oxidase A Rattus norvegicus 21-24 23988853-0 2013 Inhibition of monoamine oxidase isoforms modulates nicotine withdrawal syndrome in the rat. Nicotine 51-59 monoamine oxidase A Rattus norvegicus 14-31 23988853-1 2013 AIMS: There have been many reports of monoamine oxidase (MAO) inhibition by non-nicotine ingredients in tobacco smoke, persisting for days after smoking cessation. Nicotine 80-88 monoamine oxidase A Rattus norvegicus 38-55 23988853-1 2013 AIMS: There have been many reports of monoamine oxidase (MAO) inhibition by non-nicotine ingredients in tobacco smoke, persisting for days after smoking cessation. Nicotine 80-88 monoamine oxidase A Rattus norvegicus 57-60 23988853-2 2013 This study determined the effect of inhibiting MAO and its isoforms on nicotine withdrawal syndrome. Nicotine 71-79 monoamine oxidase A Rattus norvegicus 47-50 23988853-10 2013 KEY FINDINGS: Combined treatment with both MAO inhibitors markedly and significantly exacerbated somatically expressed nicotine withdrawal signs in nicotine infused rats, while having no significant effects in saline-infused rats. Nicotine 119-127 monoamine oxidase A Rattus norvegicus 43-46 23988853-10 2013 KEY FINDINGS: Combined treatment with both MAO inhibitors markedly and significantly exacerbated somatically expressed nicotine withdrawal signs in nicotine infused rats, while having no significant effects in saline-infused rats. Nicotine 148-156 monoamine oxidase A Rattus norvegicus 43-46 23475432-8 2013 Upon nicotine pre-exposure, brain acetylcholinesterase increased, while monoamine oxidase (MAO) decreased. Nicotine 5-13 monoamine oxidase A Rattus norvegicus 72-89 23475432-8 2013 Upon nicotine pre-exposure, brain acetylcholinesterase increased, while monoamine oxidase (MAO) decreased. Nicotine 5-13 monoamine oxidase A Rattus norvegicus 91-94 21419142-0 2011 The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Nicotine 63-71 monoamine oxidase A Rattus norvegicus 4-21 21419142-0 2011 The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Nicotine 63-71 monoamine oxidase A Rattus norvegicus 23-26 17912044-0 2007 The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats. Nicotine 90-98 monoamine oxidase A Rattus norvegicus 4-21 20936688-2 2011 Monoamine oxidase (MAO) inhibition is a major consequence of smoking and MAO inhibitors, such as tranylcypromine, increase nicotine reinforcement. Nicotine 123-131 monoamine oxidase A Rattus norvegicus 0-17 20936688-2 2011 Monoamine oxidase (MAO) inhibition is a major consequence of smoking and MAO inhibitors, such as tranylcypromine, increase nicotine reinforcement. Nicotine 123-131 monoamine oxidase A Rattus norvegicus 19-22 20936688-2 2011 Monoamine oxidase (MAO) inhibition is a major consequence of smoking and MAO inhibitors, such as tranylcypromine, increase nicotine reinforcement. Nicotine 123-131 monoamine oxidase A Rattus norvegicus 73-76 20936688-8 2011 Such animals did immediately acquire nicotine self-administration when the tranylcypromine pretreatment interval was switched to 1 h prior to testing on Day 4, indicating that an acute effect of the MAO inhibitor was responsible for enhanced nicotine reinforcement. Nicotine 37-45 monoamine oxidase A Rattus norvegicus 199-202 20936688-8 2011 Such animals did immediately acquire nicotine self-administration when the tranylcypromine pretreatment interval was switched to 1 h prior to testing on Day 4, indicating that an acute effect of the MAO inhibitor was responsible for enhanced nicotine reinforcement. Nicotine 242-250 monoamine oxidase A Rattus norvegicus 199-202 20936688-10 2011 These findings suggest that MAO inhibition enhances serotonergic transmission, which serves a critical role in the reinforcing effects of nicotine. Nicotine 138-146 monoamine oxidase A Rattus norvegicus 28-31 17912044-9 2007 These findings indicate that concomitant inhibition of MAOA and MAOB can enhance the discriminative stimulus effect of nicotine in rats. Nicotine 119-127 monoamine oxidase A Rattus norvegicus 55-59 17412372-3 2007 We report here that the inhibition of monoamine oxidase (MAO), a major effect of tobacco smoke, increases the reinforcing effect of nicotine. Nicotine 132-140 monoamine oxidase A Rattus norvegicus 57-60 17412372-5 2007 Whereas control rats did not self-administer nicotine, low doses of nicotine (2.5 to 21 microg/kg/injection) were avidly self-administered following a pretreatment with tranylcypromine (3 mg/kg), an irreversible and non-selective MAO inhibitor. Nicotine 68-76 monoamine oxidase A Rattus norvegicus 230-233 17412372-10 2007 Taken together, these results indicate that in a stringent self-administration acquisition test, MAO inhibition increases the rewarding effect of low doses of nicotine, possibly via a dopamine-dependent mechanism. Nicotine 159-167 monoamine oxidase A Rattus norvegicus 97-100 26257022-8 2015 The effect of tranylcypromine on low-dose nicotine self-administration was observed regardless of whether the injection was delivered 1-h or 23-h prior to the self-administration session, consistent with the interpretation that MAO inhibition was responsible for the increase in self-administration, instead of acute off-target effects. Nicotine 42-50 monoamine oxidase A Rattus norvegicus 228-231 26955970-0 2016 Effects of Monoamine Oxidase Inhibition on the Reinforcing Properties of Low-Dose Nicotine. Nicotine 82-90 monoamine oxidase A Rattus norvegicus 11-28 26955970-2 2016 Research suggests that cigarette smoke constituents that inhibit monoamine oxidase (MAO) may increase the reinforcing value of low doses of nicotine. Nicotine 140-148 monoamine oxidase A Rattus norvegicus 65-82 26955970-2 2016 Research suggests that cigarette smoke constituents that inhibit monoamine oxidase (MAO) may increase the reinforcing value of low doses of nicotine. Nicotine 140-148 monoamine oxidase A Rattus norvegicus 84-87 26955970-3 2016 The aim of the present experiments was to further characterize the impact of MAO inhibition on the primary reinforcing and reinforcement enhancing effects of nicotine in rats. Nicotine 158-166 monoamine oxidase A Rattus norvegicus 77-80 26955970-6 2016 The results show that (1) tranylcypromine (TCP), a known MAO inhibitor, increases sensitivity to the primary reinforcing effects of nicotine, shifting the dose-response curve for nicotine to the left, (2) inhibition of MAO-A, but not MAO-B, increases low-dose nicotine self-administration, (3) partial MAO-A inhibition, to the degree observed in chronic cigarette smokers, also increases low-dose nicotine self-administration, and (4) TCP decreases the threshold nicotine dose required for reinforcement enhancement. Nicotine 132-140 monoamine oxidase A Rattus norvegicus 57-60 26955970-6 2016 The results show that (1) tranylcypromine (TCP), a known MAO inhibitor, increases sensitivity to the primary reinforcing effects of nicotine, shifting the dose-response curve for nicotine to the left, (2) inhibition of MAO-A, but not MAO-B, increases low-dose nicotine self-administration, (3) partial MAO-A inhibition, to the degree observed in chronic cigarette smokers, also increases low-dose nicotine self-administration, and (4) TCP decreases the threshold nicotine dose required for reinforcement enhancement. Nicotine 132-140 monoamine oxidase A Rattus norvegicus 219-224 26955970-6 2016 The results show that (1) tranylcypromine (TCP), a known MAO inhibitor, increases sensitivity to the primary reinforcing effects of nicotine, shifting the dose-response curve for nicotine to the left, (2) inhibition of MAO-A, but not MAO-B, increases low-dose nicotine self-administration, (3) partial MAO-A inhibition, to the degree observed in chronic cigarette smokers, also increases low-dose nicotine self-administration, and (4) TCP decreases the threshold nicotine dose required for reinforcement enhancement. Nicotine 132-140 monoamine oxidase A Rattus norvegicus 302-307 26955970-7 2016 The results of the present experiments suggest cigarette smoke constituents that inhibit MAO-A, in the range seen in chronic smokers, are likely to increase the primary reinforcing and reinforcement enhancing effects of low doses of nicotine. Nicotine 233-241 monoamine oxidase A Rattus norvegicus 89-94 26955970-8 2016 If the FDA reduces the nicotine content of cigarettes, then variability in constituents that inhibit MAO-A could impact smoking. Nicotine 23-31 monoamine oxidase A Rattus norvegicus 101-106 17229101-0 2006 Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. Nicotine 73-81 monoamine oxidase A Rattus norvegicus 0-19 16177026-3 2005 Here, we report that inhibition of MAO dramatically and specifically increases the motivation to self-administer nicotine in rats. Nicotine 113-121 monoamine oxidase A Rattus norvegicus 35-38 16177026-5 2005 The results suggest that the inhibition of MAO activity by compounds present in tobacco smoke may combine with nicotine to produce the intense reinforcing properties of cigarette smoking that lead to addiction. Nicotine 111-119 monoamine oxidase A Rattus norvegicus 43-46 8584234-4 1995 Morphine, ethanol, lorazepam and nicotine withdrawal was associated with significant anxiety and corresponding increase in brain tribulin activity, particularly its MAO A inhibitory component. Nicotine 33-41 monoamine oxidase A Rattus norvegicus 165-170 26257022-9 2015 CONCLUSIONS: These data suggest that this cocktail of constituents does not significantly alter the primary reinforcing effects of nicotine, but constituents that inhibit MAO may increase the primary reinforcing effects of nicotine, especially at low doses. Nicotine 223-231 monoamine oxidase A Rattus norvegicus 171-174