PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24911319-4	2014	The aim of the present study was to determine if the acetylcholinesterase inhibitor donepezil has the ability to reverse nicotine withdrawal-induced deficits in contextual learning.	Nicotine	121-129	acetylcholinesterase	Mus musculus	53-73	
18164554-11	2008	The interaction between Abeta and AChE-S may also explain the different effect of nicotine on Abeta pathology in the hAChE-Tg//APPswe mice.	Nicotine	82-90	acetylcholinesterase	Mus musculus	34-38	
18776044-0	2008	Nicotine relieves anxiogenic-like behavior in mice that overexpress the read-through variant of acetylcholinesterase but not in wild-type mice.	Nicotine	0-8	acetylcholinesterase	Mus musculus	96-116	
18776044-11	2008	In summary, we found that nicotine acts as an anxiolytic in TgR mice but not in control mice and that continuously overexpressed AChE-R regulates striatal gene expression, modulating cholinergic signaling and stress-related pathways.	Nicotine	26-34	acetylcholinesterase	Mus musculus	129-135	
30099467-0	2018	Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain.	Nicotine	14-22	acetylcholinesterase	Mus musculus	76-96	
14511322-7	2003	In vitro, the cholinergic agonists muscarine (50-100 microm) and nicotine (0.5-10 microm) induced tonic activity in respiratory motoneurons and increased the frequency of inspiratory bursts in AChE+/+ and +/- animals.	Nicotine	65-73	acetylcholinesterase	Mus musculus	193-197	
1763113-0	1991	Effect of a single dose of an acetylcholinesterase inhibitor on oxotremorine- and nicotine-induced hypothermia in mice.	Nicotine	82-90	acetylcholinesterase	Mus musculus	30-50	
30099467-6	2018	Taken together, curcuminoid ameliorates nicotine dependence and relapse, in part via the inhibition of the AChE activity in the brain.	Nicotine	40-48	acetylcholinesterase	Mus musculus	107-111	
27596362-6	2016	Administration of nicotine or caffeine caused a significant (P<0.05) inhibition on AChE, ADA and Arg activities as well as a significant increase in NO level when compared with the control.	Nicotine	18-26	acetylcholinesterase	Mus musculus	86-90