PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21775771-5 2011 Prenatal nicotine increased active MMP-2 forms and interstitial collagen but had no effect on either pro- or active MMP-9 or MMP-13 forms. Nicotine 9-17 72 kDa type IV collagenase Cavia porcellus 35-40 21775771-6 2011 In the presence of nicotine, NAC decreased active MMP-2 protein levels and reversed the nicotine-induced increase in collagen staining. Nicotine 19-27 72 kDa type IV collagenase Cavia porcellus 50-55 21775771-7 2011 We conclude that prenatal nicotine alters MMP-2 expression in fetal hearts that may be mediated by reactive oxygen species generation. Nicotine 26-34 72 kDa type IV collagenase Cavia porcellus 42-47