PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27604968-0	2017	Restoration of miR-1305 relieves the inhibitory effect of nicotine on periodontal ligament-derived stem cell proliferation, migration, and osteogenic differentiation.	Nicotine	58-66	microRNA 1305	Homo sapiens	15-23	
27604968-2	2017	miR-1305 upregulation and its potential target RUNX2 downregulation exist in the PDLSCs exposed to nicotine.	Nicotine	99-107	microRNA 1305	Homo sapiens	0-8	
27604968-3	2017	In this study, we aimed to investigate whether nicotine inhibits PDLSC proliferation, migration, and osteogenic differentiation by increasing miR-1305 level and decreasing RUNX2 level.	Nicotine	47-55	microRNA 1305	Homo sapiens	142-150	
27604968-4	2017	METHODS: Quantitative real-time PCR (qRT-PCR) and Western blot assays were performed to detect the expression levels of miR-1305 and RUNX2 in the PDLSCs exposed to nicotine, respectively.	Nicotine	164-172	microRNA 1305	Homo sapiens	120-128	
27604968-8	2017	RESULTS: Nicotine promoted miR-1305 expression and inhibited RUNX2 expression in PDLSCs.	Nicotine	9-17	microRNA 1305	Homo sapiens	27-35	
27604968-9	2017	Cell proliferation, migration, and differentiation detection showed that nicotine suppressed proliferation, migration, and osteogenic differentiation of PDLSCs, and restoration of miR-1305 relieved the inhibitory effect of nicotine on PDLSCs.	Nicotine	223-231	microRNA 1305	Homo sapiens	180-188	
27604968-10	2017	Moreover, we identified and validated that RUNX2 was a direct target of miR-1305, and upregulation of RUNX2 had similar effects with the downregulation of miR-1305 on relieving the inhibitory effect of nicotine on PDLSCs.	Nicotine	202-210	microRNA 1305	Homo sapiens	72-80	
27604968-10	2017	Moreover, we identified and validated that RUNX2 was a direct target of miR-1305, and upregulation of RUNX2 had similar effects with the downregulation of miR-1305 on relieving the inhibitory effect of nicotine on PDLSCs.	Nicotine	202-210	microRNA 1305	Homo sapiens	155-163	
27604968-11	2017	CONCLUSION: Nicotine suppresses proliferation, migration, and osteogenic differentiation of PDLSCs, and restoration of miR-1305 relieves the inhibitory effect of nicotine on PDLSCs depending on its target RUNX2.	Nicotine	162-170	microRNA 1305	Homo sapiens	119-127	
25591783-8	2015	Furthermore, two nicotine-related miRNAs, hsa-miR-1305 (22.08 folds, p = 0.040) and hsa-miR-18b (15.56 folds, p = 0.018), were significantly upregulated in smoker PDLSC, suggesting these miRNAs might play an important role in the deteriorative effects on stem cells by cigarette smoke.	Nicotine	17-25	microRNA 1305	Homo sapiens	42-54