PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24062692-4 2013 Recently, variants in the nAChR genes CHRNA3, CHRNA5, and CHRNB4 have been implicated in nicotine dependence and lung cancer susceptibility. Nicotine 89-97 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 58-64 29666375-0 2018 Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population. Nicotine 102-110 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 80-86 29666375-7 2018 Our results indicated that the SNPs rs1948 and rs7178270 in CHRNB4 and rs3743075 in CHRNA3 were significantly associated with the Fagerstrom Test for Nicotine Dependence (FTND) score (p = 6.6 x 10-5; p = 2.0 x 10-4, and p = 7.0 x 10-4, respectively). Nicotine 150-158 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 60-66 25214750-5 2013 The genetic variants in the CHRNA5-CHRNA3-CHRNB4 region that predict nicotine dependence also predict a later age of smoking cessation in a community-based sample. Nicotine 69-77 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 42-48 26220977-5 2015 Of the eight cis-meQTL SNPs, only the intronic CHRNB4 SNP rs11636753 was associated with CHRNA5 methylation independently of the known SNP effects in prefrontal cortex, and it was the most significantly associated SNP with nicotine dependence across five independent cohorts (total N = 7858 European ancestry and 3238 AA participants): P = 6.7 x 10(-4), odds ratio (OR) [95% confidence interval (CI)] = 1.11 (1.05-1.18). Nicotine 223-231 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 47-53 24804708-4 2014 We previously undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes and found that rare missense variants at conserved residues in CHRNB4 are associated with reduced risk of nicotine dependence among African Americans. Nicotine 247-255 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 109-115 24804708-4 2014 We previously undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes and found that rare missense variants at conserved residues in CHRNB4 are associated with reduced risk of nicotine dependence among African Americans. Nicotine 247-255 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 204-210 23458267-2 2013 Recently, rare variants (MAF < 0.05) in CHRNB4 have been reported to be associated with a decreased risk of developing nicotine dependence. Nicotine 122-130 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 43-49 22241830-0 2012 Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine 107-115 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 62-68 23875064-1 2013 The CHRNA5-CHRNA3-CHRNB4 gene cluster on chromosome 15q25.1 encoding the cholinergic nicotinic receptor subunits is robustly associated with smoking behavior and nicotine dependence. Nicotine 162-170 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 18-24 22042234-3 2012 Genetic variation in the CHRNA5/CHRNA3/CHRNB4 gene cluster has been associated with early substance experimentation, nicotine dependence, and other drug behaviors. Nicotine 117-125 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 39-45 22241830-7 2012 DSM-IV ND symptoms associated significantly with the proxy SNP Locus 1 (rs2036527, p = .000009) and Locus 2 (rs578776, p = .0001) and tolerance factor of the Nicotine Dependence Syndrome Scale (NDSS) showed suggestive association to rs11636753 (p = .0059), rs11634351 (p = .0069), and rs1948 (p = .0071) in CHRNB4. Nicotine 158-166 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 307-313 21268243-7 2011 We focused on eight SNPs in the 15q24 region, which contains the genes for the nicotinic cholinergic receptor subunits CHRNA5, CHRNA3, and CHRNB4, and has previously been implicated in nicotine addiction and smoking cessation. Nicotine 185-193 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 139-145 22042774-0 2012 Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Nicotine 69-77 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 26-32 22042774-5 2012 Missense variants at conserved residues in CHRNB4 are associated with lower risk for nicotine dependence in African Americans and European Americans (AA P = 0.0025, odds-ratio (OR) = 0.31, 95% confidence-interval (CI) = 0.31-0.72; EA P = 0.023, OR = 0.69, 95% CI = 0.50-0.95). Nicotine 85-93 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 43-49 22042774-9 2012 The minor allele of each polymorphism increased cellular response to nicotine (T375I P = 0.01, T91I P = 0.02, R37H P = 0.003), but the largest effect on in vitro receptor activity was seen in the presence of both CHRNB4 T91I and CHRNA3 R37H (P = 2 x 10(-6)). Nicotine 69-77 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 213-219 23061658-6 2012 Moreover variants on the gene cluster CHRNA3-CHRNB4-CHRNA5 are associated with nicotine addiction antismoking therapy and antismoking therapy side-effects. Nicotine 79-87 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 45-51 20808433-1 2010 Multiple genome-wide and targeted association studies reveal a significant association of variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 with nicotine dependence. Nicotine 177-185 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 120-126 21048701-3 2011 Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the alpha3, alpha5, and beta4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools. Nicotine 185-193 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 88-94 21228559-2 2011 Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Nicotine 200-208 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 139-145 20696214-2 2010 CHRNB4, which encodes the nAChR beta4 subunit, plays a major role in the molecular mechanisms that govern nicotine withdrawal. Nicotine 106-114 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 0-6 19859904-0 2010 Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Nicotine 91-99 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 66-72 20700436-1 2010 Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. Nicotine 43-51 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 198-204 19859904-1 2010 Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) in European Americans (EAs) or others of European origin. Nicotine 279-287 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 106-112 34206324-1 2021 The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. Nicotine 155-163 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 39-45 19064933-5 2008 Genetic association studies indicate that a genetic locus, which includes the CHRNA5-CHRNA3-CHRNB4 gene cluster, plays a role in nicotine consumption and dependence. Nicotine 129-137 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 92-98 17503330-7 2007 We applied our proposed method to a genetics study of four genes that were reported to be associated with nicotine dependence and found significant joint action between CHRNB4 and NTRK2. Nicotine 106-114 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 169-175 19628476-1 2009 A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity. Nicotine 135-143 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 90-96 19628476-8 2009 Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers. Nicotine 53-61 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 27-33 19628476-8 2009 Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers. Nicotine 194-202 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 27-33 19706762-0 2009 The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Nicotine 82-90 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 18-24 19706762-1 2009 Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine dependence, smoking, and lung cancer in populations of European descent. Nicotine 187-195 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 87-93 19443489-1 2009 Nicotine dependence risk and lung cancer risk are associated with variants in a region of chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 and CHRNB4. Nicotine 0-8 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 183-189 30453884-10 2018 CONCLUSIONS: These results indicate rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. Nicotine 183-191 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 65-71 32184221-2 2020 Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3 and beta4nAChR subunits, to nicotine addiction. Nicotine 164-172 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 85-91 32184221-11 2020 These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction. Nicotine 240-248 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 216-222 28972577-4 2018 In this largest-ever GWAS meta-analysis for nicotine dependence and the largest-ever cross-ancestry GWAS meta-analysis for any smoking phenotype, we reconfirmed the well-known CHRNA5-CHRNA3-CHRNB4 genes and further yielded a novel association in the DNA methyltransferase gene DNMT3B. Nicotine 44-52 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 190-196 29993116-2 2018 Polymorphisms in CHRNA3, CHRNA5, and CHRNB4 receptors play a critical role in nicotine dependence, lung cancer (LC) risk, and chronic obstructive pulmonary disease (COPD). Nicotine 78-86 cholinergic receptor nicotinic beta 4 subunit Homo sapiens 37-43