PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31051233-1	2019	We recently found that in mouse dopaminergic neurons, the heteromer formed by the dopamine D3 receptor (D3R) and the beta2 subunit of acetylcholine nicotinic receptor (nAChR) exerts neurotrophic effects when activated by nicotine, leading to neurons with enlarged cell bodies and increased dendrite arborization.	Nicotine	221-229	dopamine receptor D3	Mus musculus	82-102	
28187919-10	2017	Taken together these data first demonstrate that a D3R-nAChR heteromer is present in DA neurons and represents the functional unit mediating the neurotrophic effects of nicotine.	Nicotine	169-177	dopamine receptor D3	Mus musculus	51-54	
23543412-9	2013	These effects were dependent on functional DA D3 receptor (D3R), because nicotine was inactive both in cultures from D3R KO mice and after pharmacologic blockade with D3R antagonist trans-N-4-2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethylcyclohexyl-4-quinolinecarboxamide (SB-277011-A) (50 nM).	Nicotine	73-81	dopamine receptor D3	Mus musculus	46-57	
23543412-9	2013	These effects were dependent on functional DA D3 receptor (D3R), because nicotine was inactive both in cultures from D3R KO mice and after pharmacologic blockade with D3R antagonist trans-N-4-2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethylcyclohexyl-4-quinolinecarboxamide (SB-277011-A) (50 nM).	Nicotine	73-81	dopamine receptor D3	Mus musculus	59-62	
23543412-10	2013	Finally, exposure to nicotine in utero (5 mg/kg/day for 5 days) resulted in increased soma area of DAergic neurons of newborn mice, effects not observed in D3 receptor null mutant mice mice.	Nicotine	21-29	dopamine receptor D3	Mus musculus	156-167	
23543412-11	2013	These findings indicate that nicotine-induced structural plasticity at mesencephalic dopaminergic neurons involves alpha4beta2 nAChRs together with dopamine D3R-mediated recruitment of ERK/Akt-mTORC1 signaling.	Nicotine	29-37	dopamine receptor D3	Mus musculus	157-160	
16176386-10	2005	A number of putative candidate genes were in proximity to regions identified with nicotine sensitivity, including the alpha2 subunit of the nicotinic acetylcholine receptor and the dopamine D3 receptor.	Nicotine	82-90	dopamine receptor D3	Mus musculus	181-201