PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8873294-3 1996 The P50 deficit is normalized in nongating subjects by nicotine. Nicotine 55-63 nuclear factor kappa B subunit 1 Homo sapiens 4-7 1450287-5 1992 Nicotine-containing gum increased P50 sensory gating to near normal levels within 30 min of administration. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 34-37 35563563-0 2022 Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-kappaB Signaling in Human Gastric Cancer Cells. Nicotine 28-36 nuclear factor kappa B subunit 1 Homo sapiens 127-136 34890707-0 2022 Nicotine stimulates IL-8 expression via ROS/NF-kappaB and ROS/MAPK/AP-1 axis in human gastric cancer cells. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 44-53 34890707-10 2022 In this study, we found that nicotine induces IL-8 expression via ROS/NF-kappaB and ROS/MAPK (Erk1/2, p38)/AP-1 axis in gastric cancer cells, thus stimulating endothelial cell proliferation and angiogenesis in the tumor microenvironment. Nicotine 29-37 nuclear factor kappa B subunit 1 Homo sapiens 70-79 35563563-9 2022 Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-kappaB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells. Nicotine 28-36 nuclear factor kappa B subunit 1 Homo sapiens 124-133 28733145-0 2017 Adipocytes promote nicotine-induced injury of endothelial cells via the NF-kappaB pathway. Nicotine 19-27 nuclear factor kappa B subunit 1 Homo sapiens 72-81 31817720-9 2019 Our results showed that TIPE2 was involved in nicotine-, nicotine-derived nitrosamine ketone (NNK)-, N-nitrosonornicotine (NNN)-, and benzo[a]pyrene (BaP)-mediated lung cancer through inhibited proliferation, survival, and migration via modulation of nuclear factor kappa B (NF-kappaB)- and NF-kappaB-regulated gene products, which are involved in the regulation of diverse processes in lung cancer cells. Nicotine 57-65 nuclear factor kappa B subunit 1 Homo sapiens 275-284 31817720-9 2019 Our results showed that TIPE2 was involved in nicotine-, nicotine-derived nitrosamine ketone (NNK)-, N-nitrosonornicotine (NNN)-, and benzo[a]pyrene (BaP)-mediated lung cancer through inhibited proliferation, survival, and migration via modulation of nuclear factor kappa B (NF-kappaB)- and NF-kappaB-regulated gene products, which are involved in the regulation of diverse processes in lung cancer cells. Nicotine 57-65 nuclear factor kappa B subunit 1 Homo sapiens 291-300 32920289-9 2020 RESULTS: In HUVECs, nicotine significantly suppressed NO production, enhanced Ang II production, downregulated eNOS expression, and upregulated expression levels of AGTR1, TLR4, MyD88, NF-kappaB, iNOS, Bax/Bcl-2 ratio, cleaved caspase-3, and cytochrome c (cyt c). Nicotine 20-28 nuclear factor kappa B subunit 1 Homo sapiens 185-194 28733145-8 2017 Our results showed that nicotine dose-dependently induces the apoptosis of HUVECs and adipocytes and is associated with increased IKKbeta and NF-kappaB p65 expression and with IkBalpha degradation. Nicotine 24-32 nuclear factor kappa B subunit 1 Homo sapiens 142-151 28733145-11 2017 Moreover, the NF-kappaB pathway plays pivotal roles in nicotine-induced vascular injury. Nicotine 55-63 nuclear factor kappa B subunit 1 Homo sapiens 14-23 23142498-0 2013 NF-kappaB pathway mediates vascular smooth muscle response to nicotine. Nicotine 62-70 nuclear factor kappa B subunit 1 Homo sapiens 0-9 28385482-0 2017 Nicotine promotes cervical carcinoma cell line HeLa migration and invasion by activating PI3k/Akt/NF-kappaB pathway in vitro. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 98-107 28385482-5 2017 In our study, we found that nicotine could accelerate HeLa cells migration and invasion, activate PI3K/Akt and NF-kappaB pathways and increase the expression of Vimentin in vitro. Nicotine 28-36 nuclear factor kappa B subunit 1 Homo sapiens 111-120 28385482-6 2017 Moreover, we demonstrated that the specific PI3K inhibitor LY294002 could reverse nicotine-induced cell migration and invasion, NF-kappaB activation and up-regulation of Vimentin. Nicotine 82-90 nuclear factor kappa B subunit 1 Homo sapiens 128-137 28385482-7 2017 Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin. Nicotine 79-87 nuclear factor kappa B subunit 1 Homo sapiens 14-23 28385482-8 2017 Simply put, these findings suggest that nicotine promotes cervical carcinoma cell line HeLa migration and invasion by activating PI3k/Akt/NF-kappaB pathway in vitro. Nicotine 40-48 nuclear factor kappa B subunit 1 Homo sapiens 138-147 25259522-2 2014 A signaling pathway downstream from the alpha7 nAChRs, which involves the collaboration of JAK2/STAT3 and NF-kappaB to interfere with signaling by Toll-like receptors (TLRs), has been implicated in this anti-inflammatory effect of nicotine. Nicotine 231-239 nuclear factor kappa B subunit 1 Homo sapiens 106-115 24828283-15 2014 Co-culture of stimulated Caco-2 cells with nicotine-activated EGCs prevented Cytomix-induced increases in P-IkappaBalpha and P-NF-kappaB expression. Nicotine 43-51 nuclear factor kappa B subunit 1 Homo sapiens 127-136 24828283-17 2014 Nicotine-activated EGCs appear to modulate barrier function by preventing the activation of the NF-kappaB pathway. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 96-105 23535252-0 2013 Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors. Nicotine 65-73 nuclear factor kappa B subunit 1 Homo sapiens 103-106 27259998-2 2016 Previously, we found that nicotine up-regulates peroxiredoxin 1 (Prx1), an important antioxidant enzyme, and nuclear factor kappa B (NFkappaB) in OSCC cells. Nicotine 26-34 nuclear factor kappa B subunit 1 Homo sapiens 133-141 24945726-12 2014 Nicotine augmented the activation of NF-kappaB in the presence of SLCO3A1. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 37-46 23744798-0 2013 Baseline dependency of nicotine"s sensory gating actions: similarities and differences in low, medium and high P50 suppressors. Nicotine 23-31 nuclear factor kappa B subunit 1 Homo sapiens 111-114 23142498-4 2013 Nicotine-induced effects were observed in SMCs by both monoculture and co-culture with the 3 mum-pore size, including the phosphorylation of IKK and IkappaB, the shift of transcription factor NF-kappaB, and the enhancement of SMC cytoskeleton protein expression and migration ability, but none were observed by co-culture with the 0.4 mum-pore size. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 192-201 23142498-7 2013 The results imply that nicotine induces SMC cytoskeleton protein up-expression and migration via the NF-kappaB signaling pathway and that EC-SMC crosstalk via CAM facilitates its response to nicotine. Nicotine 23-31 nuclear factor kappa B subunit 1 Homo sapiens 101-110 21081469-6 2011 Nicotine-mediated IkappaBalpha degradation and nuclear factor-kappa B (NF-kappaB) translocation dose-dependently. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 47-69 22187147-7 2012 Interestingly, most of the differentially expressed genes in these pathways leading to nuclear factor kappaB (NF-kappaB) activation and those important inhibitors of pathways leading to apoptosis, including FLIP and Bcl-2, were up-regulated by nicotine. Nicotine 244-252 nuclear factor kappa B subunit 1 Homo sapiens 102-108 22187147-7 2012 Interestingly, most of the differentially expressed genes in these pathways leading to nuclear factor kappaB (NF-kappaB) activation and those important inhibitors of pathways leading to apoptosis, including FLIP and Bcl-2, were up-regulated by nicotine. Nicotine 244-252 nuclear factor kappa B subunit 1 Homo sapiens 110-119 22300039-3 2012 The nonneuronal alpha7-nicotinic cholinergic receptors are a primary target for nicotine through the JAK2 and STAT3/NF-kappaB pathways, ultimately mediating the inhibition of pro-inflammatory gene transcription. Nicotine 80-88 nuclear factor kappa B subunit 1 Homo sapiens 116-125 22800703-7 2012 NF-kappaB expression in the nucleus were increased in SCC15 cells treated with 1 micromol/L nicotine for 24, 48 and 72 h and the A value for NF-kappaB DNA binding activity was 1.509, 1.093 and 0.746, respectively, which were higher than in control group (0.544). Nicotine 92-100 nuclear factor kappa B subunit 1 Homo sapiens 0-9 22800703-7 2012 NF-kappaB expression in the nucleus were increased in SCC15 cells treated with 1 micromol/L nicotine for 24, 48 and 72 h and the A value for NF-kappaB DNA binding activity was 1.509, 1.093 and 0.746, respectively, which were higher than in control group (0.544). Nicotine 92-100 nuclear factor kappa B subunit 1 Homo sapiens 141-150 22800703-8 2012 CONCLUSIONS: Nicotine induced SCC15 cell growth and apoptosis, which maybe by NF-kappaB signal pathway activated in oral cancer cells. Nicotine 13-21 nuclear factor kappa B subunit 1 Homo sapiens 78-87 21494800-0 2012 Nicotine induces pro-inflammatory response in aortic vascular smooth muscle cells through a NFkappaB/osteopontin amplification loop-dependent pathway. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 92-100 21494800-7 2012 We found that NFkappaB was activated after nicotine administration. Nicotine 43-51 nuclear factor kappa B subunit 1 Homo sapiens 14-22 21494800-10 2012 We concluded that nicotine induces a pro-inflammatory response in VSMC through a NFkappaB/osteopontin amplification loop-dependent pathway. Nicotine 18-26 nuclear factor kappa B subunit 1 Homo sapiens 81-89 21392171-11 2011 Diminished gating of P50 and associated high-frequency oscillations in the frontal brain region are indications of a deficient inhibitory cortical function in nicotine-dependent smokers. Nicotine 159-167 nuclear factor kappa B subunit 1 Homo sapiens 21-24 20665032-5 2012 Nicotine also inhibited nuclear factor (NF)-kappaB (p65) translocation from the cytoplasm to the nucleus, based on Western blotting and immunocytochemical analysis. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 24-50 21081469-10 2011 EP2 or EP4 siRNA or antagonists impaired the nicotine-mediated NF-kappaB activity, upregulation of miR-16 and miR-21 and cell proliferation. Nicotine 45-53 nuclear factor kappa B subunit 1 Homo sapiens 63-72 21081469-11 2011 Taken together, these results suggest that miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. Nicotine 130-138 nuclear factor kappa B subunit 1 Homo sapiens 112-121 21081469-6 2011 Nicotine-mediated IkappaBalpha degradation and nuclear factor-kappa B (NF-kappaB) translocation dose-dependently. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 71-80 21081469-7 2011 Knockdown of NF-kappaB by short interfering RNA (siRNA) or specific inhibitor (Bay-11-7085) markedly suppressed nicotine-induced cell proliferation and upregulation of miR-16 and miR-21. Nicotine 112-120 nuclear factor kappa B subunit 1 Homo sapiens 13-22 21081469-8 2011 Interestingly, NF-kappaB-binding sites were located in both miR-16 and miR-21 gene transcriptional elements and we showed that nicotine enhanced the binding of NF-kappaB to the promoters of miR-16 and miR-21. Nicotine 127-135 nuclear factor kappa B subunit 1 Homo sapiens 15-24 21081469-8 2011 Interestingly, NF-kappaB-binding sites were located in both miR-16 and miR-21 gene transcriptional elements and we showed that nicotine enhanced the binding of NF-kappaB to the promoters of miR-16 and miR-21. Nicotine 127-135 nuclear factor kappa B subunit 1 Homo sapiens 160-169 20943775-4 2011 Nicotine (100-300 nM, concentrations found in smoker"s blood) blocked LPS-induced NF-kappaB translocation and production of PICs interleukin (IL)-1beta and IL-6 but only partially blocked inhibitor of nuclear factor-kappaBalpha (IkappaBalpha) phosphorylation. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 82-91 20943775-2 2011 We reported previously that nicotine suppresses constitutive nuclear factor kappaB (NF-kappaB) activity and thereby proinflammatory cytokine (PIC) production in SHEP1 cells stably transfected with alpha4beta2 nicotinic receptors. Nicotine 28-36 nuclear factor kappa B subunit 1 Homo sapiens 84-93 20943775-7 2011 However, the effects of nicotine on NF-kappaB activity were significantly blocked by the highly specific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the signal transducer and activator of transcription 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859). Nicotine 24-32 nuclear factor kappa B subunit 1 Homo sapiens 36-45 19961902-0 2010 Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine D2 receptor gene polymorphism. Nicotine 11-19 nuclear factor kappa B subunit 1 Homo sapiens 64-67 19961902-2 2010 There is very little information regarding the neurochemical or genetic pathways through which nicotine regulates P50 amplitude and its suppression in human studies. Nicotine 95-103 nuclear factor kappa B subunit 1 Homo sapiens 114-117 19961902-5 2010 While nicotine (relative to placebo) attenuated S(1) P50 amplitude in A1(+) allele carriers, in the A1(-) carriers it increased S(2) P50 amplitude and increased P50 gating as indexed by an augmented gating difference wave (GDW). Nicotine 6-14 nuclear factor kappa B subunit 1 Homo sapiens 53-56 19961902-5 2010 While nicotine (relative to placebo) attenuated S(1) P50 amplitude in A1(+) allele carriers, in the A1(-) carriers it increased S(2) P50 amplitude and increased P50 gating as indexed by an augmented gating difference wave (GDW). Nicotine 6-14 nuclear factor kappa B subunit 1 Homo sapiens 133-136 19961902-5 2010 While nicotine (relative to placebo) attenuated S(1) P50 amplitude in A1(+) allele carriers, in the A1(-) carriers it increased S(2) P50 amplitude and increased P50 gating as indexed by an augmented gating difference wave (GDW). Nicotine 6-14 nuclear factor kappa B subunit 1 Homo sapiens 133-136 19147120-0 2009 Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 64-72 19147120-2 2009 We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts. Nicotine 94-102 nuclear factor kappa B subunit 1 Homo sapiens 53-75 19147120-2 2009 We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts. Nicotine 94-102 nuclear factor kappa B subunit 1 Homo sapiens 77-85 19147120-4 2009 The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%. Nicotine 4-12 nuclear factor kappa B subunit 1 Homo sapiens 116-124 19147120-5 2009 Nicotine stimulation of IkappaBalpha, an inhibitor of NFkappaB degradation, was also characterized by Western blotting. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 54-62 19147120-8 2009 These results suggest that nicotine is taken up by human gingival fibroblasts and that it then stimulates COX-2 expression via the activation of NFkappaB and the subsequent release of prostaglandin E(2). Nicotine 27-35 nuclear factor kappa B subunit 1 Homo sapiens 145-153 19247191-4 2009 We examined nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells pretreated with ghrelin and detected the activity of protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), and nuclear factor (NF)-kappaB. Nicotine 12-20 nuclear factor kappa B subunit 1 Homo sapiens 219-245 17878927-0 2007 Nicotine inhibits cytokine production by placenta cells via NFkappaB: potential role in pregnancy-induced hypertension. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 60-68 18205746-0 2008 Differential induction of heme oxygenase-1 against nicotine-induced cytotoxicity via the PI3K, MAPK, and NF-kappa B pathways in immortalized and malignant human oral keratinocytes. Nicotine 51-59 nuclear factor kappa B subunit 1 Homo sapiens 105-115 18205746-7 2008 Molecular inhibitors of the ERK, p38 MAP kinase, PI3 K, and NF-kappaB signaling pathways blocked the cytotoxic effects and induction of HO-1 expression by nicotine. Nicotine 155-163 nuclear factor kappa B subunit 1 Homo sapiens 60-69 17878927-9 2007 Taken together, our results suggest that cholinergic agonists, including nicotine, may reduce cytokine production by placenta cells via NFkappaB to protect against PIH. Nicotine 73-81 nuclear factor kappa B subunit 1 Homo sapiens 136-144 17657162-7 2007 Indeed, nicotine caused oxygen free radical production as well as activation of Rho A and NF-kappaB pathways, evaluated by malondialdehyde levels, pulldown assay and by electrophoretic mobility shift assay, respectively. Nicotine 8-16 nuclear factor kappa B subunit 1 Homo sapiens 90-99 17657162-8 2007 Superoxide dimutase, Rho A (Y-27639) and NF-kappaB inhibitors (pyrrolidine dithiocarbamate ammonium, Bay 11-7082) suppressed nicotine effects on CAM expression. Nicotine 125-133 nuclear factor kappa B subunit 1 Homo sapiens 41-50 17657162-9 2007 HMG-CoA reductase inhibitors prevented these nicotine-mediated effects by inhibiting free radical generation and by modulating activation of Rho A and NF-kappaB pathways. Nicotine 45-53 nuclear factor kappa B subunit 1 Homo sapiens 151-160 16500770-0 2006 Nicotine treatment alters NF-kappaB expression in human cytomegalovirus-infected ARPE-19 cells. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 26-35 16598845-4 2006 In the present study, we designed a nicotine-apoptosis system, by pre-treatment of nicotine making lung cancer cell A549 to be in a physiological nicotine environment, and observed that nicotine promoted cell proliferation and prevented the menadione-induced apoptosis, and exerts its role of anti-apoptosis by shift of apoptotic stage induced by menadione from late apoptotic stage to early apoptotic stage, in which NF-kappaB was up-regulated. Nicotine 36-44 nuclear factor kappa B subunit 1 Homo sapiens 418-427 16598845-5 2006 Interference analysis of NF-kappaB in A549 cells showed that knock down of NF-kappaB resulted in apoptosis promotion and counteracted the protective effect of nicotine. Nicotine 159-167 nuclear factor kappa B subunit 1 Homo sapiens 25-34 16598845-5 2006 Interference analysis of NF-kappaB in A549 cells showed that knock down of NF-kappaB resulted in apoptosis promotion and counteracted the protective effect of nicotine. Nicotine 159-167 nuclear factor kappa B subunit 1 Homo sapiens 75-84 16598845-6 2006 The findings suggest that nicotine has potential effect in lung cancer genesis, especially in patients with undetectable early tumor development and development of specific NF-kappaB inhibitors would represent a potentially exciting new pharmacotherapy for tobacco-related lung cancer. Nicotine 26-34 nuclear factor kappa B subunit 1 Homo sapiens 173-182 16500770-5 2006 CONCLUSIONS: Treatment of HCMV-infected ARPE-19 cells with nicotine at a physiologic dose dampened the downregulation of NF-kappaB observed in HCMV-infected ARPE-19 cells without nicotine treatment. Nicotine 59-67 nuclear factor kappa B subunit 1 Homo sapiens 121-130 15927799-3 2005 Nicotine administration improves P50 inhibition, presumably by achieving additional activation of these diminished receptors, but its toxicity and marked tachyphylaxis make it an ineffective therapeutic. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 33-36 12960242-0 2003 Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB. Nicotine 0-8 nuclear factor kappa B subunit 1 Homo sapiens 120-129 12960242-4 2003 A degradation of IkappaB-alpha/beta proteins and an activity of NF-kappaB p65 and p50 were enhanced following nicotine treatment. Nicotine 110-118 nuclear factor kappa B subunit 1 Homo sapiens 64-73 12960242-6 2003 The NOS inhibitor, nomega-Nitro-l-arginine methyl ester, prevented nicotine-induced IL-8 production, with an entire abrogation of DHR oxidation, IkappaB degradation, and NF-kappaB activity. Nicotine 67-75 nuclear factor kappa B subunit 1 Homo sapiens 170-179 12960242-7 2003 Neutrophils spontaneously produced NO whose production was not increased, but rather decreased by nicotine stimulation, suggesting that superoxide, produced by nicotine, generates peroxynitrite by reacting with preformed NO, which enhances the NF-kappaB activity, thereby producing IL-8. Nicotine 160-168 nuclear factor kappa B subunit 1 Homo sapiens 244-253 12960242-10 2003 In conclusion, nicotine stimulates neutrophil-IL-8 production via nAChR by generating peroxynitrite and subsequent NF-kappaB activation, and the IL-8 appears to contribute to leukocytosis in tobacco smokers. Nicotine 15-23 nuclear factor kappa B subunit 1 Homo sapiens 115-124