PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30984342-6	2019	The results of the TUNEL assay and western blot experiments showed that the block of alpha3beta4-nAChRs abrogated nicotine-mediated protection of NRC from CVB3-induced apoptosis, and this effect displayed a substantial correlation with the protein expressions of pAkt, survivin, and Cleaved Caspase-3.	Nicotine	114-122	baculoviral IAP repeat-containing 5	Mus musculus	269-277	
31967849-9	2020	Accordingly, the expression of survivin, involved in cell cycle regulation, also follows a different kinetics in nicotine lung extracts.	Nicotine	113-121	baculoviral IAP repeat-containing 5	Mus musculus	31-39	
30984342-8	2019	As a result, nicotine-mediated induction of pAkt and survivin was abolished by LY294002; meanwhile, apoptotic NRC were increased accompanied by an increase of Cleaved Caspase-3 expression.	Nicotine	13-21	baculoviral IAP repeat-containing 5	Mus musculus	53-61	
18635526-2	2008	The tobacco component nicotine increases the transcription of the survivin gene in non-small cell lung cancer cells.	Nicotine	22-30	baculoviral IAP repeat-containing 5	Mus musculus	66-74	
18635526-4	2008	We investigated the effects of the tobacco components nicotine and its related carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on survivin expression in normal human bronchial epithelial (NHBE) cells and examined the role of survivin in the malignant transformation of normal human bronchial epithelial (HBE) cells induced by these components.	Nicotine	54-62	baculoviral IAP repeat-containing 5	Mus musculus	146-154	
18635526-6	2008	Nicotine and NNK increased survivin mRNA and protein expression levels in primary cultured NHBE cells and immortalized HBE cells.	Nicotine	0-8	baculoviral IAP repeat-containing 5	Mus musculus	27-35	
18635526-8	2008	Nicotine and NNK stimulated the Akt-mammalian target of rapamycin (mTOR) pathway in NHBE cells, leading to increased de novo synthesis of survivin protein.	Nicotine	0-8	baculoviral IAP repeat-containing 5	Mus musculus	138-146	
18635526-11	2008	These findings suggest that NNK and nicotine induce survivin protein synthesis in NHBE cells by activating the Akt-mTOR pathway and thus blockade of the pathway effectively inhibits the tobacco-induced malignant transformation of HBE cells.	Nicotine	36-44	baculoviral IAP repeat-containing 5	Mus musculus	52-60