PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22614008-4	2013	This nicotine-mediated MUC4 overexpression was via the alpha7 subunit of nicotinic acetylcholine receptor (nAChR) stimulation and subsequent activation of the JAK2/STAT3 downstream signaling cascade in cooperation with the MEK/ERK1/2 pathway; this effect was blocked by the alpha7nAChR antagonists, alpha-bungarotoxin and mecamylamine, and by specific siRNA-mediated STAT3 inhibition.	Nicotine	5-13	Janus kinase 2	Mus musculus	159-163	
25616906-11	2015	In conclusion, nicotine has an anti-inflammatory effect on RA by downregulating production of IL-6 and MCP-1 in FLSs, and this is mediated through activation of the JAK2-STAT3 signal pathway.	Nicotine	15-23	Janus kinase 2	Mus musculus	165-169	
35111269-12	2022	Conclusions: Taken together, the presented results indicate the positive effect of inhibition of nicotine induced overexpression of alpha7nAChR and JAK2, unique to HCC.	Nicotine	97-105	Janus kinase 2	Mus musculus	148-152	
19293145-6	2009	Abeta peptides and nicotine differentially activate several intracellular signaling pathways, including the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog pathway, the extracellular signal-regulated kinase/mitogen-activated protein kinase, and JAK-2/STAT-3 pathways.	Nicotine	19-27	Janus kinase 2	Mus musculus	271-276	
34997096-7	2022	Furthermore, nicotine suppressed CCL21-induced bone marrow-derived pDC migration due to Rac 1 inactivation, which was reversed by methyllycaconitine, a JAK2 inhibitor AG490 or caspase-3 inhibitor AZ-10417808.	Nicotine	13-21	Janus kinase 2	Mus musculus	152-156