PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19776730-4 2010 Transcriptional upregulation of hippocampal jun-N terminal kinase 1 (JNK1) mRNA was found in mice that learned contextual fear conditioning (FC) in the presence of nicotine, whereas neither learning alone nor nicotine administration alone exerted an effect. Nicotine 164-172 mitogen-activated protein kinase 8 Mus musculus 44-67 20113502-0 2010 Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. Nicotine 0-8 mitogen-activated protein kinase 8 Mus musculus 99-102 20113502-12 2010 Confocal-microscopy-based immunohistochemistry showed that 4 days of nicotine treatment induced activation (phosphorylation) of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1 and 2 (ERK1/2) and p38. Nicotine 69-77 mitogen-activated protein kinase 8 Mus musculus 128-151 20113502-12 2010 Confocal-microscopy-based immunohistochemistry showed that 4 days of nicotine treatment induced activation (phosphorylation) of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1 and 2 (ERK1/2) and p38. Nicotine 69-77 mitogen-activated protein kinase 8 Mus musculus 153-156 20113502-13 2010 Inhibition of JNK with its specific inhibitor SP600125 abolished the nicotine-induced effects on kinin receptor-mediated contractions and reverted the enhanced receptor mRNA expression. Nicotine 69-77 mitogen-activated protein kinase 8 Mus musculus 14-17 19776730-4 2010 Transcriptional upregulation of hippocampal jun-N terminal kinase 1 (JNK1) mRNA was found in mice that learned contextual fear conditioning (FC) in the presence of nicotine, whereas neither learning alone nor nicotine administration alone exerted an effect. Nicotine 164-172 mitogen-activated protein kinase 8 Mus musculus 69-73 19776730-5 2010 Furthermore, the upregulation of JNK1 was absent in beta2 nicotinic receptor subunit knockout mice, which are mice that do not show enhanced learning by nicotine. Nicotine 153-161 mitogen-activated protein kinase 8 Mus musculus 33-37 19776730-6 2010 Finally, hippocampal JNK activation was increased in mice that were administered nicotine before conditioning, and the inhibition of JNK during consolidation prevented the nicotine-induced enhancement of contextual FC. Nicotine 81-89 mitogen-activated protein kinase 8 Mus musculus 21-24 19776730-6 2010 Finally, hippocampal JNK activation was increased in mice that were administered nicotine before conditioning, and the inhibition of JNK during consolidation prevented the nicotine-induced enhancement of contextual FC. Nicotine 172-180 mitogen-activated protein kinase 8 Mus musculus 21-24 19776730-6 2010 Finally, hippocampal JNK activation was increased in mice that were administered nicotine before conditioning, and the inhibition of JNK during consolidation prevented the nicotine-induced enhancement of contextual FC. Nicotine 172-180 mitogen-activated protein kinase 8 Mus musculus 133-136 19776730-7 2010 These data suggest that nicotine and learning interact to alter hippocampal JNK1 gene expression and related signaling processes, thus resulting in strengthened contextual memories. Nicotine 24-32 mitogen-activated protein kinase 8 Mus musculus 76-80 27235579-0 2016 c-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning. Nicotine 43-51 mitogen-activated protein kinase 8 Mus musculus 0-25 32362142-8 2020 In MEF cells, nicotine increased the expression of Prx1 and inhibited apoptosis and expression of p-p38 and p-JNK. Nicotine 14-22 mitogen-activated protein kinase 8 Mus musculus 110-113 31913329-13 2020 PNU or nicotine reduced cytokine expression and JNK activation, but improved insulin resistance induced by palmitate. Nicotine 7-15 mitogen-activated protein kinase 8 Mus musculus 48-51 27235579-3 2016 The effects of nicotine on learning may involve recruitment of signaling through the c-Jun N-terminal kinase family (JNK 1-3). Nicotine 15-23 mitogen-activated protein kinase 8 Mus musculus 117-122 27235579-4 2016 Learning in the presence of acute nicotine increases the transcription of mitogen-activated protein kinase 8 (MAPK8, also known as JNK1), likely through a CREB-dependent mechanism. Nicotine 34-42 mitogen-activated protein kinase 8 Mus musculus 74-108 27235579-4 2016 Learning in the presence of acute nicotine increases the transcription of mitogen-activated protein kinase 8 (MAPK8, also known as JNK1), likely through a CREB-dependent mechanism. Nicotine 34-42 mitogen-activated protein kinase 8 Mus musculus 110-115 27235579-4 2016 Learning in the presence of acute nicotine increases the transcription of mitogen-activated protein kinase 8 (MAPK8, also known as JNK1), likely through a CREB-dependent mechanism. Nicotine 34-42 mitogen-activated protein kinase 8 Mus musculus 131-135 27235579-5 2016 The functional significance of JNK1 in the effects of acute nicotine on learning, however, is unknown. Nicotine 60-68 mitogen-activated protein kinase 8 Mus musculus 31-35 27235579-6 2016 The current studies undertook a backward genetic approach to determine the functional contribution JNK1 protein makes to nicotine-enhanced contextual fear conditioning. Nicotine 121-129 mitogen-activated protein kinase 8 Mus musculus 99-103 27235579-12 2016 These data suggest that JNK1 may be recruited by nicotine and is functionally necessary for the acute effects of nicotine on learning and memory. Nicotine 49-57 mitogen-activated protein kinase 8 Mus musculus 24-28 27235579-12 2016 These data suggest that JNK1 may be recruited by nicotine and is functionally necessary for the acute effects of nicotine on learning and memory. Nicotine 113-121 mitogen-activated protein kinase 8 Mus musculus 24-28 25381636-7 2015 Furthermore, the nicotine exposure equivalent to plasma levels found in regular smokers can augment VCAM-1, MMP-2, and MMP-9 expressions through the alpha7-nAChR-JNK pathway. Nicotine 17-25 mitogen-activated protein kinase 8 Mus musculus 162-165 27688602-3 2016 This study aimed to elucidate whether the JNK inhibitor SP600125 can attenuate nicotine plus angiotensin II- (AngII-) induced AAA formation and to assess the underlying molecular mechanisms. Nicotine 79-87 mitogen-activated protein kinase 8 Mus musculus 42-45 25381636-0 2015 Nicotine-induced upregulation of VCAM-1, MMP-2, and MMP-9 through the alpha7-nAChR-JNK pathway in RAW264.7 and MOVAS cells. Nicotine 0-8 mitogen-activated protein kinase 8 Mus musculus 83-86 25381636-4 2015 When cells were pretreated with either SP600125 (JNK inhibitor) or PNU-282987 (alpha7-nAChR agonist) prior to nicotine exposure, the nicotine-induced upregulation of VCAM-1, MMP-2, MMP-9, and p-JNK was suppressed, with a joint treatment producing a more significant inhibitory effect. Nicotine 110-118 mitogen-activated protein kinase 8 Mus musculus 49-52 25381636-4 2015 When cells were pretreated with either SP600125 (JNK inhibitor) or PNU-282987 (alpha7-nAChR agonist) prior to nicotine exposure, the nicotine-induced upregulation of VCAM-1, MMP-2, MMP-9, and p-JNK was suppressed, with a joint treatment producing a more significant inhibitory effect. Nicotine 133-141 mitogen-activated protein kinase 8 Mus musculus 49-52 25381636-4 2015 When cells were pretreated with either SP600125 (JNK inhibitor) or PNU-282987 (alpha7-nAChR agonist) prior to nicotine exposure, the nicotine-induced upregulation of VCAM-1, MMP-2, MMP-9, and p-JNK was suppressed, with a joint treatment producing a more significant inhibitory effect. Nicotine 133-141 mitogen-activated protein kinase 8 Mus musculus 194-197 24669857-0 2014 Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Nicotine 0-8 mitogen-activated protein kinase 8 Mus musculus 60-63 24669857-11 2014 Specific inhibition of JNK attenuated nicotine"s effects. Nicotine 38-46 mitogen-activated protein kinase 8 Mus musculus 23-26 24669857-12 2014 In conclusion, long-term exposure to nicotine up-regulated the expression of TLR4 and -6 via a JNK-related pathway, causing an exaggeration of the LPS-induced local airway inflammation and increased AHR. Nicotine 37-45 mitogen-activated protein kinase 8 Mus musculus 95-98 24399025-8 2014 Both Erk-JNK-p38 and PI3K-Akt signaling pathways could be activated by nicotine treatment in Raw264.7 and El4 cells. Nicotine 71-79 mitogen-activated protein kinase 8 Mus musculus 9-12 24399025-9 2014 Notably, when Erk-JNK and PI3K-Akt activities were inhibited, nicotine-augmented cell proliferation and anti-apoptotic effects were abolished accordingly. Nicotine 62-70 mitogen-activated protein kinase 8 Mus musculus 18-21