PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27251500-3 2016 Kaempferol, kaempferol 7-O-alpha-L-rhamnopyranoside, puerarin and ferulic acid showed strong inhibition of nicotine-induced vascular cell adhesion molecule (VCAM-1) expression while kaempferol, kaempferin, and caffeic acid attenuated intercellular adhesion molecule (ICAM-1) expression. Nicotine 107-115 vascular cell adhesion molecule 1 Homo sapiens 157-163 26474621-8 2015 In HUVECs, the expressions of CCL-8, Vcam-1, VLA4alpha, OX40 and OX40L were significantly up-regulated by nicotine and P.g-LPS combination compared with nicotine alone, P.g-LPS alone and the untreated control. Nicotine 106-114 vascular cell adhesion molecule 1 Homo sapiens 37-43 26474621-10 2015 CONCLUSION: P.g-LPS in combination with nicotine could recruit monocytes to endothelial lesion through up-regulation of CCL-8, and promote adhesion of monocytes to endothelial cells through enhancement of Vcam-1/VLA4alpha and OX40/OX40L interactions, which could be involved in the initiation and development of atherosclerosis. Nicotine 40-48 vascular cell adhesion molecule 1 Homo sapiens 205-211 19247191-0 2009 Inhibitory effect of ghrelin on nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells. Nicotine 32-40 vascular cell adhesion molecule 1 Homo sapiens 49-55 20162355-0 2010 HUVEC ICAM-1 and VCAM-1 synthesis in response to potentially athero-prone and athero-protective mechanical and nicotine chemical stimuli. Nicotine 111-119 vascular cell adhesion molecule 1 Homo sapiens 17-23 20162355-14 2010 In third bioreactor test case, a nicotine chemical stimulus induced a substantial VCAM-1 up-regulation and a moderate ICAM-1 up-regulation. Nicotine 33-41 vascular cell adhesion molecule 1 Homo sapiens 82-88 20162355-17 2010 Also, the level of VCAM-1 expressed by the nicotine stimulated ECs showed an elevated level of sensitivity to the athero-prone mechanical stimuli. Nicotine 43-51 vascular cell adhesion molecule 1 Homo sapiens 19-25 19247191-3 2009 However, it is unknown how ghrelin regulates nicotine-induced vascular cell adhesion molecule-1 (VCAM-1) expression. Nicotine 45-53 vascular cell adhesion molecule 1 Homo sapiens 62-95 19247191-3 2009 However, it is unknown how ghrelin regulates nicotine-induced vascular cell adhesion molecule-1 (VCAM-1) expression. Nicotine 45-53 vascular cell adhesion molecule 1 Homo sapiens 97-103 19247191-4 2009 We examined nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells pretreated with ghrelin and detected the activity of protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), and nuclear factor (NF)-kappaB. Nicotine 12-20 vascular cell adhesion molecule 1 Homo sapiens 29-35 19247191-5 2009 Our study showed that ghrelin inhibited nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells in a concentration-dependent and time-dependent way. Nicotine 40-48 vascular cell adhesion molecule 1 Homo sapiens 57-63 19247191-7 2009 The results suggest that ghrelin inhibits nicotine-induced VCAM-1 expression, and PKC, p38 MAPK, and NF-kappaB play active roles in that process. Nicotine 42-50 vascular cell adhesion molecule 1 Homo sapiens 59-65 16644474-6 2006 Moreover, calcium chelator BAPTA, ERK1/2 inhibitor PD98059, p38 inhibitor SB203580 significantly reduced the production of nicotine-activated surface/soluble VCAM-1 and E-selectin and both of the remained levels were no longer regulated by estrogen. Nicotine 123-131 vascular cell adhesion molecule 1 Homo sapiens 158-164 17657162-4 2007 METHODS AND RESULTS: Real-time PCR showed that nicotine induced a dose-dependent increase in mRNA levels for vascular cellular adhesion molecule-1 (VCAM-1)/intercellular adhesion molecule-1 (ICAM-1). Nicotine 47-55 vascular cell adhesion molecule 1 Homo sapiens 109-146 17657162-4 2007 METHODS AND RESULTS: Real-time PCR showed that nicotine induced a dose-dependent increase in mRNA levels for vascular cellular adhesion molecule-1 (VCAM-1)/intercellular adhesion molecule-1 (ICAM-1). Nicotine 47-55 vascular cell adhesion molecule 1 Homo sapiens 148-154 17657162-5 2007 Fluorescent-activated cell sorting analysis showed that nicotine induced expression of functionally active VCAM-1/ICAM-1, since they increased leukocyte adherence to HCAECs. Nicotine 56-64 vascular cell adhesion molecule 1 Homo sapiens 107-113 16644474-7 2006 Our study here provides the information of decrease effect of mER-mediated estrogen through Ca2+ and ERK1/2, p38 MAPK signaling pathway on nicotine-stimulated expression of surface/soluble VCAM-1 and E-selectin in HUVECs. Nicotine 139-147 vascular cell adhesion molecule 1 Homo sapiens 189-195 16257255-2 2006 The result showed that nicotine could induce surface/soluble vascular cell adhesion molecule (VCAM-1) and endothelial selectin (E-selectin) expression in a time-response decline manner and the peak appeared at 15 min. Nicotine 23-31 vascular cell adhesion molecule 1 Homo sapiens 94-100 16257255-5 2006 They also inhibited the surface/soluble VCAM-1, E-selectin production of HUVECs modulated by nicotine. Nicotine 93-101 vascular cell adhesion molecule 1 Homo sapiens 40-46 16257255-6 2006 Therefore, we concluded that: (i) nicotine obviously up-regulates VCAM-1 and E-selectin expression at 15 min in HUVECs, (ii) nicotine activates HUVECs triggered by the ERK1/2 and p38 phosphorylation with an involvement of intracellular calcium mobilization chiefly mediated by alpha7 nicotinic receptor, (iii) intracellular Ca2+ activates a sequential pathway from alpha7 nicotinic receptor to the phosphorylation of ERK1/2, p38. Nicotine 34-42 vascular cell adhesion molecule 1 Homo sapiens 66-72 16257255-6 2006 Therefore, we concluded that: (i) nicotine obviously up-regulates VCAM-1 and E-selectin expression at 15 min in HUVECs, (ii) nicotine activates HUVECs triggered by the ERK1/2 and p38 phosphorylation with an involvement of intracellular calcium mobilization chiefly mediated by alpha7 nicotinic receptor, (iii) intracellular Ca2+ activates a sequential pathway from alpha7 nicotinic receptor to the phosphorylation of ERK1/2, p38. Nicotine 125-133 vascular cell adhesion molecule 1 Homo sapiens 66-72 16845181-0 2006 Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1. Nicotine 0-8 vascular cell adhesion molecule 1 Homo sapiens 75-81 16845181-3 2006 The aim of this study was to determine the effect of nicotine on the expression of the adhesion molecules, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in endothelial cells and to determine the involvement of important known intermediaries, protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), and the transcription factors NF-kappaB and AP-1. Nicotine 53-61 vascular cell adhesion molecule 1 Homo sapiens 152-192 16845181-6 2006 We observed that nicotine increased the expression of ICAM-1 and VCAM-1 with a peak at 6 h. p38 MAPK was activated after 5 min exposure to 10-8 mol/L nicotine and returned to baseline levels by 30 min. Nicotine 17-25 vascular cell adhesion molecule 1 Homo sapiens 65-71 16845181-6 2006 We observed that nicotine increased the expression of ICAM-1 and VCAM-1 with a peak at 6 h. p38 MAPK was activated after 5 min exposure to 10-8 mol/L nicotine and returned to baseline levels by 30 min. Nicotine 150-158 vascular cell adhesion molecule 1 Homo sapiens 65-71 16845181-9 2006 Inhibitors of p38 MAPK, PKC, and NF-kappaB suppressed nicotine-stimulated expression of ICAM-1 and VCAM-1. Nicotine 54-62 vascular cell adhesion molecule 1 Homo sapiens 99-105 16845181-10 2006 Our results indicate that nicotine enhances the expression of ICAM-1 and VCAM-1 on the endothelial cell surface via a second messenger pathway which involves PKC and p38 MAPK-mediated activation of NF-kappaB and AP-1, resulting in increased expression of these cellular adhesion molecules. Nicotine 26-34 vascular cell adhesion molecule 1 Homo sapiens 73-79 15354631-0 2004 Nicotine induces mononuclear leukocyte adhesion and expression of adhesion molecules, VCAM and ICAM, in endothelial cells in vitro. Nicotine 0-8 vascular cell adhesion molecule 1 Homo sapiens 86-90 15354631-18 2004 Nicotine exposure at 3 hr induced expression of VCAM (ISI = 30.85+/-0.77) and to a lesser extent ICAM (ISI = 16.6+/-1.39) (p < 0.001). Nicotine 0-8 vascular cell adhesion molecule 1 Homo sapiens 48-52 15354631-20 2004 These data show nicotine"s ability to activate HUVEC as evidenced by induction of ICAM and VCAM expression in vitro. Nicotine 16-24 vascular cell adhesion molecule 1 Homo sapiens 91-95 11166759-3 2001 Treatment of primary human coronary artery endothelial cells with nicotine for 24 h at concentrations (10(-5) and 10(-7) M) similar to those in the blood of smokers resulted in increased mRNA levels of endothelial nitric oxide synthase, angiotensin-I converting enzyme, tissue-type plasminogen activator, plasminogen activator inhibitor-1, von Willebrand factor, and vascular cell adhesion molecule-1. Nicotine 66-74 vascular cell adhesion molecule 1 Homo sapiens 367-400