PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26184482-0	2015	Nicotine Induces Tumor Growth and Chemoresistance through Activation of the PI3K/Akt/mTOR Pathway in Bladder Cancer.	Nicotine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	85-89	
26184482-11	2015	In conclusion, nicotine increases tumor growth and induces acquired chemoresistance through activation of the PI3K/Akt/mTOR pathway in bladder cancer.	Nicotine	15-23	mechanistic target of rapamycin kinase	Homo sapiens	119-123	
22966072-6	2012	The two pathways known to stimulate IRS-1(ser636) phosphorylation (p44/42 mitogen-activated protein kinase [MAPK] and mammalian target of rapamycin [mTOR]) were both stimulated by nicotine in culture.	Nicotine	180-188	mechanistic target of rapamycin kinase	Homo sapiens	118-147	
24916432-0	2014	The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization.	Nicotine	86-94	mechanistic target of rapamycin kinase	Homo sapiens	4-33	
22966072-6	2012	The two pathways known to stimulate IRS-1(ser636) phosphorylation (p44/42 mitogen-activated protein kinase [MAPK] and mammalian target of rapamycin [mTOR]) were both stimulated by nicotine in culture.	Nicotine	180-188	mechanistic target of rapamycin kinase	Homo sapiens	149-153	
22966072-7	2012	Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1(ser636) phosphorylation and normalized insulin sensitivity.	Nicotine	48-56	mechanistic target of rapamycin kinase	Homo sapiens	14-18	
22966072-8	2012	These data indicate nicotine induces insulin resistance in skeletal muscle by activating mTOR.	Nicotine	20-28	mechanistic target of rapamycin kinase	Homo sapiens	89-93	
20851953-10	2010	This is the first study to demonstrate that curcumin inhibits the adverse effects of nicotine by blocking nicotine-induced activation of the AKT/MTOR pathway in HNSCC, which retards cell migration.	Nicotine	85-93	mechanistic target of rapamycin kinase	Homo sapiens	145-149	
20851953-10	2010	This is the first study to demonstrate that curcumin inhibits the adverse effects of nicotine by blocking nicotine-induced activation of the AKT/MTOR pathway in HNSCC, which retards cell migration.	Nicotine	106-114	mechanistic target of rapamycin kinase	Homo sapiens	145-149	
30836163-5	2019	We found that nicotine simultaneously activates AKT/mTOR pathway in HPV-immortalized cervical epithelial (H8) cell line, followed by elevation of 4EBP1/eIF4E axis expression and its translational activity with dose-dependent and time-dependent manners.	Nicotine	14-22	mechanistic target of rapamycin kinase	Homo sapiens	52-56	
19654299-0	2009	Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha.	Nicotine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	103-107	
19654299-3	2009	Here, we explore the potential link between nicotine and PPARbeta/delta and report that nicotine increases the expression of PPARbeta/delta protein; this effect was blocked by an alpha7 nAChR antagonist (alpha-bungarotoxin), by alpha7 nAChR short interfering RNA, and by inhibitors of phosphatidylinositol 3-kinase (PI3K; wortmannin and LY294002) and mammalian target of rapamycin (mTOR; rapamycin).	Nicotine	88-96	mechanistic target of rapamycin kinase	Homo sapiens	351-380	
19654299-3	2009	Here, we explore the potential link between nicotine and PPARbeta/delta and report that nicotine increases the expression of PPARbeta/delta protein; this effect was blocked by an alpha7 nAChR antagonist (alpha-bungarotoxin), by alpha7 nAChR short interfering RNA, and by inhibitors of phosphatidylinositol 3-kinase (PI3K; wortmannin and LY294002) and mammalian target of rapamycin (mTOR; rapamycin).	Nicotine	88-96	mechanistic target of rapamycin kinase	Homo sapiens	382-386	
18635526-8	2008	Nicotine and NNK stimulated the Akt-mammalian target of rapamycin (mTOR) pathway in NHBE cells, leading to increased de novo synthesis of survivin protein.	Nicotine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	67-71	
18635526-11	2008	These findings suggest that NNK and nicotine induce survivin protein synthesis in NHBE cells by activating the Akt-mTOR pathway and thus blockade of the pathway effectively inhibits the tobacco-induced malignant transformation of HBE cells.	Nicotine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	115-119	
17600315-9	2007	The fibronectin-inducing effects of nicotine were associated with activation of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)/mammalian target of rapamycin (mTOR) signaling pathways, and were abrogated by inhibitors of ERK (PD98059), PI3-K (LY294002), and mTOR (rapamycin), but not by inhibitors of protein kinase (PK)C (calphostin C) and PKA (H89).	Nicotine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	162-191	
17600315-9	2007	The fibronectin-inducing effects of nicotine were associated with activation of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)/mammalian target of rapamycin (mTOR) signaling pathways, and were abrogated by inhibitors of ERK (PD98059), PI3-K (LY294002), and mTOR (rapamycin), but not by inhibitors of protein kinase (PK)C (calphostin C) and PKA (H89).	Nicotine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	193-197	
17600315-9	2007	The fibronectin-inducing effects of nicotine were associated with activation of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)/mammalian target of rapamycin (mTOR) signaling pathways, and were abrogated by inhibitors of ERK (PD98059), PI3-K (LY294002), and mTOR (rapamycin), but not by inhibitors of protein kinase (PK)C (calphostin C) and PKA (H89).	Nicotine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	292-296	
19654299-8	2009	Collectively, our results show that nicotine increases PPARbeta/delta gene expression through alpha7 nAChR-mediated activation of PI3K/mTOR signals that inhibit AP-2alpha protein expression and DNA binding activity to the PPARbeta/delta gene promoter.	Nicotine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	135-139	
33953172-10	2021	Thus, our findings not only confirmed that nicotine alleviated MIA-induced pain behavior and cartilage degradation via stimulating the alpha7-nAChRs/mTOR signal pathway but found the potential role of alpha7-nAChRs in mediating the balance between apoptosis and autophagy.	Nicotine	43-51	mechanistic target of rapamycin kinase	Homo sapiens	149-153	
30836163-11	2019	Taken together, it can be concluded that nicotine promotes H8 cell proliferation by activating AKT/mTOR pathway, as well as 4EBP1/eIF4E axis and its translational activity.	Nicotine	41-49	mechanistic target of rapamycin kinase	Homo sapiens	99-103	
27224911-4	2016	We demonstrated that nicotine increase the expressiones of mannose receptor and Toll-like receptor 4 (TLR4) via PI3K-Akt-mTOR-p70S6 pathway.	Nicotine	21-29	mechanistic target of rapamycin kinase	Homo sapiens	121-125	
26397133-1	2015	In tobacco-associated lung cancers, the protein kinase B/mammalian target of rapamycin (Akt/mTOR) pathway frequently is activated by nicotine and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	Nicotine	133-141	mechanistic target of rapamycin kinase	Homo sapiens	57-86	
26397133-1	2015	In tobacco-associated lung cancers, the protein kinase B/mammalian target of rapamycin (Akt/mTOR) pathway frequently is activated by nicotine and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	Nicotine	133-141	mechanistic target of rapamycin kinase	Homo sapiens	92-96